A systematic review and meta-analysis of the effect of prophylactic tranexamic acid treatment in major benign uterine surgery
Research output: Contribution to journal › Review › Research › peer-review
Background: The value of tranexamic acid (TA) treatment as bleeding prophylaxis in major uterine surgery is unclear. Objectives: To evaluate the antihemorrhagic effect of prophylactic TA treatment in major benign uterine surgery. Search strategy: PubMed, Embase, Cochrane Library, and Web of Science were searched from 1980 to 2015 without language restriction using search terms related to major uterine surgery combined with TA. Selection criteria: Randomized controlled trials comparing prophylactic TA with placebo or no intervention in women undergoing elective major benign uterine surgery. Data collection and analysis: Basic information and outcomes were collected and meta-analyses performed. Main results: Sixteen trials were included, with five trials considered to have an overall low risk of bias. In cesarean delivery, TA significantly reduced intraoperative bleeding (mean −136 mL, 95% confidence interval [CI] −189 to −83), blood loss of more than 1000 mL (relative risk 0.38, 95% CI 0.18–0.81), and blood transfusion (relative risk 0.32, 95% CI 0.17–0.59). In abdominal myomectomy, TA also significantly reduced intraoperative bleeding (mean −251 mL, 95% CI −391 to −110). Conclusions: Prophylactic TA treatment significantly reduced operative bleeding in women undergoing elective cesarean delivery or abdominal myomectomy. Additional randomized trials with low risk of bias are needed.
Original language | English |
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Journal | International Journal of Gynecology & Obstetrics |
Volume | 136 |
Issue number | 2 |
Pages (from-to) | 120-127 |
Number of pages | 8 |
ISSN | 0020-7292 |
DOIs | |
Publication status | Published - Feb 2017 |
- Antifibrinolytic agent, Antifibrinolytic therapy, Bleeding prophylaxis, Obstetric and gynecologic surgery, Surgical bleeding, Tranexamic acid
Research areas
ID: 196716312