A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. / Tsushima, Hanako; Malabarba, Maria Grazia; Confalonieri, Stefano; Senic-Matuglia, Francesca; Verhoef, Lisette G G C; Bartocci, Cristina; D'Ario, Giovanni; Cocito, Andrea; Di Fiore, Pier Paolo; Salcini, Anna Elisabetta.
In: PloS one, Vol. 8, No. 2, 2013, p. e56383.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode
AU - Tsushima, Hanako
AU - Malabarba, Maria Grazia
AU - Confalonieri, Stefano
AU - Senic-Matuglia, Francesca
AU - Verhoef, Lisette G G C
AU - Bartocci, Cristina
AU - D'Ario, Giovanni
AU - Cocito, Andrea
AU - Di Fiore, Pier Paolo
AU - Salcini, Anna Elisabetta
PY - 2013
Y1 - 2013
N2 - Protein interaction modules coordinate the connections within and the activity of intracellular signaling networks. The Eps15 Homology (EH) module, a protein-protein interaction domain that is a key feature of the EH-network, was originally identified in a few proteins involved in endocytosis and vesicle trafficking, and has subsequently also been implicated in actin reorganization, nuclear shuttling, and DNA repair. Here we report an extensive characterization of the physical connections and of the functional wirings of the EH-network in the nematode. Our data show that one of the major physiological roles of the EH-network is in neurotransmission. In addition, we found that the proteins of the network intersect, and possibly coordinate, a number of "territories" of cellular activity including endocytosis/recycling/vesicle transport, actin dynamics, general metabolism and signal transduction, ubiquitination/degradation of proteins, DNA replication/repair, and miRNA biogenesis and processing.
AB - Protein interaction modules coordinate the connections within and the activity of intracellular signaling networks. The Eps15 Homology (EH) module, a protein-protein interaction domain that is a key feature of the EH-network, was originally identified in a few proteins involved in endocytosis and vesicle trafficking, and has subsequently also been implicated in actin reorganization, nuclear shuttling, and DNA repair. Here we report an extensive characterization of the physical connections and of the functional wirings of the EH-network in the nematode. Our data show that one of the major physiological roles of the EH-network is in neurotransmission. In addition, we found that the proteins of the network intersect, and possibly coordinate, a number of "territories" of cellular activity including endocytosis/recycling/vesicle transport, actin dynamics, general metabolism and signal transduction, ubiquitination/degradation of proteins, DNA replication/repair, and miRNA biogenesis and processing.
KW - Adaptor Proteins, Vesicular Transport
KW - Animals
KW - Caenorhabditis elegans
KW - Caenorhabditis elegans Proteins
KW - Gene Expression Regulation
KW - Protein Structure, Tertiary
KW - Reproducibility of Results
KW - Synaptic Transmission
KW - Two-Hybrid System Techniques
U2 - 10.1371/journal.pone.0056383
DO - 10.1371/journal.pone.0056383
M3 - Journal article
C2 - 23424658
VL - 8
SP - e56383
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 2
ER -
ID: 100985785