A single bout of high-intensity interval training improves motor skill retention in individuals with stroke
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A single bout of high-intensity interval training improves motor skill retention in individuals with stroke. / Nepveu, Jean-Francois; Thiel, Alexander; Tang, Ada; Fung, Joyce; Lundbye-Jensen, Jesper; Boyd, Lara A; Roig, Marc.
In: Neurorehabilitation and Neural Repair, Vol. 31, No. 8, 2017, p. 726-735.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A single bout of high-intensity interval training improves motor skill retention in individuals with stroke
AU - Nepveu, Jean-Francois
AU - Thiel, Alexander
AU - Tang, Ada
AU - Fung, Joyce
AU - Lundbye-Jensen, Jesper
AU - Boyd, Lara A
AU - Roig, Marc
N1 - CURIS 2017 NEXS 185
PY - 2017
Y1 - 2017
N2 - Background: One bout of high-intensity cardiovascular exercise performed immediately after practicing a motor skill promotes changes in the neuroplasticity of the motor cortex and facilitates motor learning in nondisabled individuals.Objective: To determine if a bout of exercise performed at high intensity is sufficient to induce neuroplastic changes and improve motor skill retention in patients with chronic stroke.Methods: Twenty-two patients with different levels of motor impairment were recruited. On the first session, the effects of a maximal graded exercise test on corticospinal and intracortical excitability were assessed from the affected and unaffected primary motor cortex representational area of a hand muscle with transcranial magnetic stimulation. On the second session, participants were randomly assigned to an exercise or a nonexercise control group. Immediately after practicing a motor task, the exercise group performed 15 minutes of high-intensity interval training while the control group rested. Twenty-four hours after motor practice all participants completed a test of the motor task to assess skill retention.Results: The graded exercise test reduced interhemispheric imbalances in GABAA-mediated short-interval intracortical inhibition but changes in other markers of excitability were not statistically significant. The group that performed high-intensity interval training showed a better retention of the motor skill.Conclusions: The performance of a maximal graded exercise test triggers only modest neuroplastic changes in patients with chronic stroke. However, a single bout of high-intensity interval training performed immediately after motor practice improves skill retention, which could potentially accelerate motor recovery in these individuals.
AB - Background: One bout of high-intensity cardiovascular exercise performed immediately after practicing a motor skill promotes changes in the neuroplasticity of the motor cortex and facilitates motor learning in nondisabled individuals.Objective: To determine if a bout of exercise performed at high intensity is sufficient to induce neuroplastic changes and improve motor skill retention in patients with chronic stroke.Methods: Twenty-two patients with different levels of motor impairment were recruited. On the first session, the effects of a maximal graded exercise test on corticospinal and intracortical excitability were assessed from the affected and unaffected primary motor cortex representational area of a hand muscle with transcranial magnetic stimulation. On the second session, participants were randomly assigned to an exercise or a nonexercise control group. Immediately after practicing a motor task, the exercise group performed 15 minutes of high-intensity interval training while the control group rested. Twenty-four hours after motor practice all participants completed a test of the motor task to assess skill retention.Results: The graded exercise test reduced interhemispheric imbalances in GABAA-mediated short-interval intracortical inhibition but changes in other markers of excitability were not statistically significant. The group that performed high-intensity interval training showed a better retention of the motor skill.Conclusions: The performance of a maximal graded exercise test triggers only modest neuroplastic changes in patients with chronic stroke. However, a single bout of high-intensity interval training performed immediately after motor practice improves skill retention, which could potentially accelerate motor recovery in these individuals.
KW - Stroke
KW - Cardiovascular exercise
KW - Motor skill learning
KW - Rehabilitation
KW - Memory
KW - Neuronal plasticity
KW - Transcranial megnetic stimulation
U2 - 10.1177/1545968317718269
DO - 10.1177/1545968317718269
M3 - Journal article
C2 - 28691645
VL - 31
SP - 726
EP - 735
JO - Neurorehabilitation and Neural Repair
JF - Neurorehabilitation and Neural Repair
SN - 1545-9683
IS - 8
ER -
ID: 181902244