A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain. / Larsen, Inge; Hjulsager, Charlotte Kristiane; Holm, Anders; Olsen, John Elmerdahl; Nielsen, Søren Saxmose; Nielsen, Jens Peter.

In: Preventive Veterinary Medicine, Vol. 123, 01.01.2016, p. 52-59.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Larsen, I, Hjulsager, CK, Holm, A, Olsen, JE, Nielsen, SS & Nielsen, JP 2016, 'A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain', Preventive Veterinary Medicine, vol. 123, pp. 52-59. https://doi.org/10.1016/j.prevetmed.2015.12.004

APA

Larsen, I., Hjulsager, C. K., Holm, A., Olsen, J. E., Nielsen, S. S., & Nielsen, J. P. (2016). A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain. Preventive Veterinary Medicine, 123, 52-59. https://doi.org/10.1016/j.prevetmed.2015.12.004

Vancouver

Larsen I, Hjulsager CK, Holm A, Olsen JE, Nielsen SS, Nielsen JP. A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain. Preventive Veterinary Medicine. 2016 Jan 1;123:52-59. https://doi.org/10.1016/j.prevetmed.2015.12.004

Author

Larsen, Inge ; Hjulsager, Charlotte Kristiane ; Holm, Anders ; Olsen, John Elmerdahl ; Nielsen, Søren Saxmose ; Nielsen, Jens Peter. / A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain. In: Preventive Veterinary Medicine. 2016 ; Vol. 123. pp. 52-59.

Bibtex

@article{2a3dd47628534cfa9b37b91bec91f67e,

title = "A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain",

abstract = "Oral treatment with antimicrobials is widely used in pig production for the control of gastrointestinal infections. Lawsonia intracellularis (LI) causes enteritis in pigs older than six weeks of age and is commonly treated with antimicrobials. The objective of this study was to evaluate the efficacy of three oral dosage regimens (5, 10 and 20mg/kg body weight) of oxytetracycline (OTC) in drinking water over a five-day period on diarrhoea, faecal shedding of LI and average daily weight gain (ADG). A randomised clinical trial was carried out in four Danish pig herds. In total, 539 animals from 37 batches of nursery pigs were included in the study. The dosage regimens were randomly allocated to each batch and initiated at presence of assumed LI-related diarrhoea. In general, all OTC doses used for the treatment of LI infection resulted in reduced diarrhoea and LI shedding after treatment. Treatment with a low dose of 5mg/kg OTC per kg body weight, however, tended to cause more watery faeces and resulted in higher odds of pigs shedding LI above detection level when compared to medium and high doses (with odds ratios of 5.5 and 8.4, respectively). No association was found between the dose of OTC and the ADG. In conclusion, a dose of 5mg OTC per kg body weight was adequate for reducing the high-level LI shedding associated with enteropathy, but a dose of 10mg OTC per kg body weight was necessary to obtain a maximum reduction in LI shedding.",

author = "Inge Larsen and Hjulsager, {Charlotte Kristiane} and Anders Holm and Olsen, {John Elmerdahl} and Nielsen, {S{\o}ren Saxmose} and Nielsen, {Jens Peter}",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.prevetmed.2015.12.004",

language = "English",

volume = "123",

pages = "52--59",

journal = "Preventive Veterinary Medicine",

issn = "0167-5877",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain

AU - Larsen, Inge

AU - Hjulsager, Charlotte Kristiane

AU - Holm, Anders

AU - Olsen, John Elmerdahl

AU - Nielsen, Søren Saxmose

AU - Nielsen, Jens Peter

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Oral treatment with antimicrobials is widely used in pig production for the control of gastrointestinal infections. Lawsonia intracellularis (LI) causes enteritis in pigs older than six weeks of age and is commonly treated with antimicrobials. The objective of this study was to evaluate the efficacy of three oral dosage regimens (5, 10 and 20mg/kg body weight) of oxytetracycline (OTC) in drinking water over a five-day period on diarrhoea, faecal shedding of LI and average daily weight gain (ADG). A randomised clinical trial was carried out in four Danish pig herds. In total, 539 animals from 37 batches of nursery pigs were included in the study. The dosage regimens were randomly allocated to each batch and initiated at presence of assumed LI-related diarrhoea. In general, all OTC doses used for the treatment of LI infection resulted in reduced diarrhoea and LI shedding after treatment. Treatment with a low dose of 5mg/kg OTC per kg body weight, however, tended to cause more watery faeces and resulted in higher odds of pigs shedding LI above detection level when compared to medium and high doses (with odds ratios of 5.5 and 8.4, respectively). No association was found between the dose of OTC and the ADG. In conclusion, a dose of 5mg OTC per kg body weight was adequate for reducing the high-level LI shedding associated with enteropathy, but a dose of 10mg OTC per kg body weight was necessary to obtain a maximum reduction in LI shedding.

AB - Oral treatment with antimicrobials is widely used in pig production for the control of gastrointestinal infections. Lawsonia intracellularis (LI) causes enteritis in pigs older than six weeks of age and is commonly treated with antimicrobials. The objective of this study was to evaluate the efficacy of three oral dosage regimens (5, 10 and 20mg/kg body weight) of oxytetracycline (OTC) in drinking water over a five-day period on diarrhoea, faecal shedding of LI and average daily weight gain (ADG). A randomised clinical trial was carried out in four Danish pig herds. In total, 539 animals from 37 batches of nursery pigs were included in the study. The dosage regimens were randomly allocated to each batch and initiated at presence of assumed LI-related diarrhoea. In general, all OTC doses used for the treatment of LI infection resulted in reduced diarrhoea and LI shedding after treatment. Treatment with a low dose of 5mg/kg OTC per kg body weight, however, tended to cause more watery faeces and resulted in higher odds of pigs shedding LI above detection level when compared to medium and high doses (with odds ratios of 5.5 and 8.4, respectively). No association was found between the dose of OTC and the ADG. In conclusion, a dose of 5mg OTC per kg body weight was adequate for reducing the high-level LI shedding associated with enteropathy, but a dose of 10mg OTC per kg body weight was necessary to obtain a maximum reduction in LI shedding.

U2 - 10.1016/j.prevetmed.2015.12.004

DO - 10.1016/j.prevetmed.2015.12.004

M3 - Journal article

C2 - 26718056

VL - 123

SP - 52

EP - 59

JO - Preventive Veterinary Medicine

JF - Preventive Veterinary Medicine

SN - 0167-5877

ER -

ID: 153823601