A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature
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A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature. / Knopp, Matthias Manne; Gannon, Natasha; Porsch, Ilona; Rask, Malte Bille; Olesen, Niels Erik; Langguth, Peter; Holm, René; Rades, Thomas.
In: Journal of Pharmaceutical Sciences, Vol. 105, No. 9, 09.2016, p. 2621-2624.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature
AU - Knopp, Matthias Manne
AU - Gannon, Natasha
AU - Porsch, Ilona
AU - Rask, Malte Bille
AU - Olesen, Niels Erik
AU - Langguth, Peter
AU - Holm, René
AU - Rades, Thomas
N1 - Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.
PY - 2016/9
Y1 - 2016/9
N2 - The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.
AB - The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.
KW - Journal Article
U2 - 10.1016/j.xphs.2016.02.017
DO - 10.1016/j.xphs.2016.02.017
M3 - Journal article
C2 - 27012222
VL - 105
SP - 2621
EP - 2624
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 9
ER -
ID: 169382770