A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis
Research output: Contribution to journal › Journal article › Research › peer-review
During epithelial morphogenesis, a complex comprising the βPIX (PAK-interacting exchange factor β) and class I PAKs (p21-activated kinases) is recruited to adherens junctions. Scrib, the mammalian ortholog of the Drosophila polarity determinant and tumor suppressor Scribble, binds βPIX directly. Scrib is also targeted to adherens junctions by E-cadherin, where Scrib strengthens cadherin-mediated cell-cell adhesion. Although a role for the Scrib-βPIX-PAK signaling complex in promoting membrane protrusion at wound edges has been elucidated, a function for this complex at adherens junctions remains unknown.
Original language | English |
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Journal | Current biology : CB |
Volume | 22 |
Issue number | 19 |
Pages (from-to) | 1747-54 |
Number of pages | 8 |
DOIs | |
Publication status | Published - 9 Oct 2012 |
- Adherens Junctions, Animals, Anoikis, Apoptosis, Cadherins, Cell Survival, Dogs, Epithelial Cells, Gene Knockdown Techniques, Guanine Nucleotide Exchange Factors, Intracellular Signaling Peptides and Proteins, Madin Darby Canine Kidney Cells, Osmotic Pressure, Signal Transduction, p21-Activated Kinases
Research areas
ID: 45826313