A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans

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A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans. / Rojo Romanos, Teresa; Gramstrup Petersen, Jakob; Redo Riveiro, Alba; Pocock, Roger David John.

In: Genetics (Print), 12.11.2014.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rojo Romanos, T, Gramstrup Petersen, J, Redo Riveiro, A & Pocock, RDJ 2014, 'A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans', Genetics (Print). https://doi.org/10.1534/genetics.114.172049

APA

Rojo Romanos, T., Gramstrup Petersen, J., Redo Riveiro, A., & Pocock, R. D. J. (2014). A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans. Genetics (Print). https://doi.org/10.1534/genetics.114.172049

Vancouver

Rojo Romanos T, Gramstrup Petersen J, Redo Riveiro A, Pocock RDJ. A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans. Genetics (Print). 2014 Nov 12. https://doi.org/10.1534/genetics.114.172049

Author

Rojo Romanos, Teresa ; Gramstrup Petersen, Jakob ; Redo Riveiro, Alba ; Pocock, Roger David John. / A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans. In: Genetics (Print). 2014.

Bibtex

@article{af9cc91fc34e425882ac985396a7f55b,

title = "A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans",

abstract = "Oxygen (O2) and carbon dioxide (CO2) provoke distinct olfactory behaviors via specialized sensory neurons across metazoa. In the nematode Caenorhabditis elegans, the BAG sensory neurons are specialized to sense changes in both O2 and CO2 levels in the environment. The precise functionality of these neurons is specified by the co-expression of a membrane-bound receptor-type guanylyl cylase GCY-9 that is required for responses to CO2 upshifts, and the soluble guanylyl cylases GCY-31 and GCY-33 that mediate responses to downshifts in O2. Expression of these gas-sensing molecules in the BAG neurons is partially, though not completely, controlled by ETS-5, an ETS-domain-containing transcription factor, and EGL-13, a Sox transcription factor. We report here, the identification of EGL-46, a zinc-finger transcription factor, which regulates BAG gas-sensing fate in partially parallel pathways to ETS-5 and EGL-13. Thereby, three conserved transcription factors collaborate to ensure neuron type-specific identity features of the BAG gas-sensing neurons.",

author = "{Rojo Romanos}, Teresa and {Gramstrup Petersen}, Jakob and {Redo Riveiro}, Alba and Pocock, {Roger David John}",

note = "Copyright {\textcopyright} 2014, The Genetics Society of America.",

year = "2014",

month = nov,

day = "12",

doi = "10.1534/genetics.114.172049",

language = "English",

journal = "Genetics",

issn = "1943-2631",

publisher = "The Genetics Society of America (GSA)",

}

RIS

TY - JOUR

T1 - A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans

AU - Rojo Romanos, Teresa

AU - Gramstrup Petersen, Jakob

AU - Redo Riveiro, Alba

AU - Pocock, Roger David John

PY - 2014/11/12

Y1 - 2014/11/12

N2 - Oxygen (O2) and carbon dioxide (CO2) provoke distinct olfactory behaviors via specialized sensory neurons across metazoa. In the nematode Caenorhabditis elegans, the BAG sensory neurons are specialized to sense changes in both O2 and CO2 levels in the environment. The precise functionality of these neurons is specified by the co-expression of a membrane-bound receptor-type guanylyl cylase GCY-9 that is required for responses to CO2 upshifts, and the soluble guanylyl cylases GCY-31 and GCY-33 that mediate responses to downshifts in O2. Expression of these gas-sensing molecules in the BAG neurons is partially, though not completely, controlled by ETS-5, an ETS-domain-containing transcription factor, and EGL-13, a Sox transcription factor. We report here, the identification of EGL-46, a zinc-finger transcription factor, which regulates BAG gas-sensing fate in partially parallel pathways to ETS-5 and EGL-13. Thereby, three conserved transcription factors collaborate to ensure neuron type-specific identity features of the BAG gas-sensing neurons.

AB - Oxygen (O2) and carbon dioxide (CO2) provoke distinct olfactory behaviors via specialized sensory neurons across metazoa. In the nematode Caenorhabditis elegans, the BAG sensory neurons are specialized to sense changes in both O2 and CO2 levels in the environment. The precise functionality of these neurons is specified by the co-expression of a membrane-bound receptor-type guanylyl cylase GCY-9 that is required for responses to CO2 upshifts, and the soluble guanylyl cylases GCY-31 and GCY-33 that mediate responses to downshifts in O2. Expression of these gas-sensing molecules in the BAG neurons is partially, though not completely, controlled by ETS-5, an ETS-domain-containing transcription factor, and EGL-13, a Sox transcription factor. We report here, the identification of EGL-46, a zinc-finger transcription factor, which regulates BAG gas-sensing fate in partially parallel pathways to ETS-5 and EGL-13. Thereby, three conserved transcription factors collaborate to ensure neuron type-specific identity features of the BAG gas-sensing neurons.

U2 - 10.1534/genetics.114.172049

DO - 10.1534/genetics.114.172049

M3 - Journal article

C2 - 25395666

JO - Genetics

JF - Genetics

SN - 1943-2631

ER -

ID: 127491575