A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans
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A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans. / Rojo Romanos, Teresa; Gramstrup Petersen, Jakob; Redo Riveiro, Alba; Pocock, Roger David John.
In: Genetics (Print), 12.11.2014.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A Novel Role for the Zinc-Finger Transcription Factor EGL-46 in the Differentiation of Gas-Sensing Neurons in Caenorhabditis elegans
AU - Rojo Romanos, Teresa
AU - Gramstrup Petersen, Jakob
AU - Redo Riveiro, Alba
AU - Pocock, Roger David John
N1 - Copyright © 2014, The Genetics Society of America.
PY - 2014/11/12
Y1 - 2014/11/12
N2 - Oxygen (O2) and carbon dioxide (CO2) provoke distinct olfactory behaviors via specialized sensory neurons across metazoa. In the nematode Caenorhabditis elegans, the BAG sensory neurons are specialized to sense changes in both O2 and CO2 levels in the environment. The precise functionality of these neurons is specified by the co-expression of a membrane-bound receptor-type guanylyl cylase GCY-9 that is required for responses to CO2 upshifts, and the soluble guanylyl cylases GCY-31 and GCY-33 that mediate responses to downshifts in O2. Expression of these gas-sensing molecules in the BAG neurons is partially, though not completely, controlled by ETS-5, an ETS-domain-containing transcription factor, and EGL-13, a Sox transcription factor. We report here, the identification of EGL-46, a zinc-finger transcription factor, which regulates BAG gas-sensing fate in partially parallel pathways to ETS-5 and EGL-13. Thereby, three conserved transcription factors collaborate to ensure neuron type-specific identity features of the BAG gas-sensing neurons.
AB - Oxygen (O2) and carbon dioxide (CO2) provoke distinct olfactory behaviors via specialized sensory neurons across metazoa. In the nematode Caenorhabditis elegans, the BAG sensory neurons are specialized to sense changes in both O2 and CO2 levels in the environment. The precise functionality of these neurons is specified by the co-expression of a membrane-bound receptor-type guanylyl cylase GCY-9 that is required for responses to CO2 upshifts, and the soluble guanylyl cylases GCY-31 and GCY-33 that mediate responses to downshifts in O2. Expression of these gas-sensing molecules in the BAG neurons is partially, though not completely, controlled by ETS-5, an ETS-domain-containing transcription factor, and EGL-13, a Sox transcription factor. We report here, the identification of EGL-46, a zinc-finger transcription factor, which regulates BAG gas-sensing fate in partially parallel pathways to ETS-5 and EGL-13. Thereby, three conserved transcription factors collaborate to ensure neuron type-specific identity features of the BAG gas-sensing neurons.
U2 - 10.1534/genetics.114.172049
DO - 10.1534/genetics.114.172049
M3 - Journal article
C2 - 25395666
JO - Genetics
JF - Genetics
SN - 1943-2631
ER -
ID: 127491575