A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

Research output: Contribution to journalJournal articleResearchpeer-review

  • Honglin Song
  • Susan J Ramus
  • Jonathan Tyrer
  • Kelly L Bolton
  • Aleksandra Gentry-Maharaj
  • Eva Wozniak
  • Hoda Anton-Culver
  • Jenny Chang-Claude
  • Daniel W Cramer
  • Richard DiCioccio
  • Thilo Dörk
  • Ellen L Goode
  • Marc T Goodman
  • Joellen M Schildkraut
  • Thomas Sellers
  • Laura Baglietto
  • Matthias W Beckmann
  • Jonathan Beesley
  • Jan Blaakaer
  • Michael E Carney
  • Stephen Chanock
  • Zhihua Chen
  • Julie M Cunningham
  • Ed Dicks
  • Jennifer A Doherty
  • Matthias Dürst
  • Arif B Ekici
  • David Fenstermacher
  • Brooke L Fridley
  • Graham Giles
  • Martin E Gore
  • Immaculata De Vivo
  • Peter Hillemanns
  • Claus Hogdall
  • Estrid Hogdall
  • Edwin S Iversen
  • Ian J Jacobs
  • Anna Jakubowska
  • Dong Li
  • Jolanta Lissowska
  • Jan Lubinski
  • Galina Lurie
  • Valerie McGuire
  • John McLaughlin
  • Krzysztof Medrek
  • Patricia G Moorman
  • Kirsten Moysich
  • Steven Narod
  • Catherine Phelan
  • Australian Cancer (Ovarian) Study
  • Australian Ovarian Cancer Study Group
  • Ovarian Cancer Association Consortium
  • Kjær, Susanne Krüger
Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and approximately 2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Australia. We identified 12 SNPs at 9p22 associated with disease risk (P < 10(-8)). The most significant SNP (rs3814113; P = 2.5 x 10(-17)) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls, confirming its association (combined data odds ratio (OR) = 0.82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77, 95% CI 0.73-0.81, P(trend) = 4.1 x 10(-21)).
Original languageEnglish
JournalNature Genetics
Volume41
Issue number9
Pages (from-to)996-1000
Number of pages4
ISSN1061-4036
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Alleles; Australia; Base Sequence; Case-Control Studies; Chromosome Mapping; Chromosomes, Human, Pair 9; Confidence Intervals; Europe; European Continental Ancestry Group; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Haplotypes; Heterozygote; Homozygote; Humans; Linkage Disequilibrium; Molecular Sequence Data; Odds Ratio; Ovarian Neoplasms; Polymorphism, Single Nucleotide; Risk Factors; United States

ID: 19977326