TY - JOUR

T1 - [99mTc]diphosphonate uptake and hemodynamics in experimental arthritis

T2 - effect of naproxen in the canine carrageenan injection model

AU - Hansen, E S

AU - He, S Z

AU - Søballe, K

AU - Kjølseth, D

AU - Henriksen, T B

AU - Hjortdal, V E

AU - Bünger, C

PY - 1992/9

Y1 - 1992/9

N2 - The impact of naproxen treatment on juxta-articular hemodynamics and bone metabolism in experimental juvenile arthritis was studied in the articular carrageenan injection model. Unilateral gonarthritis was induced for 12 weeks in eight dogs receiving naproxen (dosage, 2 mg/kg) and eight controls. Regional blood flow was assessed by the microsphere method, plasma volume by the distribution space of [125I]fibrinogen, and bone metabolism by the 2-h uptake of [99mTc]diphosphonate ([99mTc]DPD). Synovial effusion was less prominent with naproxen treatment as judged by joint fluid volume and pressure. Naproxen reduced the arthritic capsular hyperemia, almost normalized a severe blood flow increase in patella and both juxta-articular epiphyses, ameliorated an expansion of plasma volume in the patella and the distal femoral epiphysis, and normalized an increased [99mTc]DPD uptake in subchondral femoral bone and the tibial cortex. Significantly increased arteriovenous shunting in the arthritic extremity was unaffected by naproxen. The study suggests that long-term cyclooxygenase inhibition offers protection against hemodynamic and metabolic changes in juxta-articular bone secondary to synovial inflammation.

AB - The impact of naproxen treatment on juxta-articular hemodynamics and bone metabolism in experimental juvenile arthritis was studied in the articular carrageenan injection model. Unilateral gonarthritis was induced for 12 weeks in eight dogs receiving naproxen (dosage, 2 mg/kg) and eight controls. Regional blood flow was assessed by the microsphere method, plasma volume by the distribution space of [125I]fibrinogen, and bone metabolism by the 2-h uptake of [99mTc]diphosphonate ([99mTc]DPD). Synovial effusion was less prominent with naproxen treatment as judged by joint fluid volume and pressure. Naproxen reduced the arthritic capsular hyperemia, almost normalized a severe blood flow increase in patella and both juxta-articular epiphyses, ameliorated an expansion of plasma volume in the patella and the distal femoral epiphysis, and normalized an increased [99mTc]DPD uptake in subchondral femoral bone and the tibial cortex. Significantly increased arteriovenous shunting in the arthritic extremity was unaffected by naproxen. The study suggests that long-term cyclooxygenase inhibition offers protection against hemodynamic and metabolic changes in juxta-articular bone secondary to synovial inflammation.

KW - Animals

KW - Arthritis/chemically induced

KW - Bone and Bones/blood supply

KW - Capillary Permeability/physiology

KW - Carrageenan/administration & dosage

KW - Diphosphonates/pharmacokinetics

KW - Disease Models, Animal

KW - Dogs

KW - Growth Plate/blood supply

KW - Hemodynamics/drug effects

KW - Homeostasis

KW - Injections

KW - Microspheres

KW - Naproxen/pharmacology

KW - Regional Blood Flow

KW - Technetium/pharmacokinetics

KW - Technetium Compounds

U2 - 10.1002/jor.1100100507

DO - 10.1002/jor.1100100507

M3 - Journal article

C2 - 1500978

VL - 10

SP - 647

EP - 656

JO - Journal of Orthopaedic Research

JF - Journal of Orthopaedic Research

SN - 0736-0266

IS - 5

ER -