Simon Erlendsson
Assistant professor
Montoya Group
Blegdamsvej 3B, 2200 København N., Bygning 4, Building: 04-1-21
Research
The research is centred on structural neurobiology with the overall aim of understanding molecular mechanisms underlying neuronal communication. In particularly, the research focuses on synaptic transmission in the brain i.e. how we learn and how memories are formed and maintained. Recent and ongoing work addresses the structure and function of domesticated endogenous retroviral elements and how these have evolved and influence neuronal communication. Many of these still form retroviral-like capsids when expressed in cells, and it has also been shown that these endogenous capsids are capable of protecting and transporting genetic and enzymatic material between cells in a retroviral-like manner. While these pathways are still poorly understood, endogenous retroviral element are important in many aspects of cellular function and may also provide a platform for targeted delivery of medicine.
Methodology
A wide range of cell biological methods combined with structural and biophysical techniques are used. In particular, cryo electron microscopy (cryo-EM) is used to study molecular complexes and capsids in detail. Combined with cryo electron tomography (cryo-ET) and subtomogram averaging even highly heterogenous complexes can be investigated in their native cellular environment.
Selected publications
Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
Erlendsson, Simon, Morado, D. R., Cullen, H. B., Feschotte, C., Shepherd, J. D. & Briggs, J. A. G., 2020, In : Nature Neuroscience. 23, p. 172-175Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets
Erlendsson, Simon, Thorsen, Thor Seneca, Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In : eLife. 8, p. 1-27 e39180.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor
Nielsen, L. D., Pedersen, Christian Parsbæk, Erlendsson, Simon & Teilum, Kaare, 2019, In : Structure. 27, 7, p. 1071-1081, e1-e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer
Pastuzyn, E. D., Day, C. E., Kearns, R. B., Kyrke-Smith, M., Taibi, A. V., McCormick, J., Yoder, N., Belnap, D. M., Erlendsson, Simon, Morado, D. R., Briggs, J. A. G., Feschotte, C. & Shepherd, J. D., 2018, In : Cell. 172, 1-2, p. 275-288, E18 33 p.Research output: Contribution to journal › Journal article › Research › peer-review
The native structure of the assembled matrix protein 1 of influenza A virus
Peukes, J., Xiong, X., Erlendsson, Simon, Qu, K., Wan, W., Calder, L., Schraidt, O., Kummer, S., M.V. Freund , S., Kräusslich, H. & A.G. Briggs, J., Sep 2020, In : Nature.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
Erlendsson, Simon, Gotfryd, Kamil, Larsen, F. H., Mortensen, J. S., Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In : eLife. 6, 9 p., e19314.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 37722958
Most downloads
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Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
Research output: Contribution to journal › Journal article › Research › peer-review
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241
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(S)Pinning down protein interactions by NMR
Research output: Contribution to journal › Review › Research › peer-review
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173
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An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1
Research output: Contribution to journal › Journal article › Research › peer-review
Published