Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias

    Tysman, M., Toppari, J., Main, Katharina Maria, Adamsson, A., Wohlfahrt-Veje, C., Antignac, J., Le Bizec, B., Löyttyniemi, E., Skakkebæk, Niels Erik & Virtanen, H. E., 2023, In: Chemosphere. 313, 8 p., 137343.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism

    Soerensen, R. R., Johannsen, T. H., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., Oct 2016, In: Hormones. 15, 4, p. 518-526 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio

    Holm, M., Rajpert-De Meyts, E., Andersson, A. & Skakkebæk, Niels Erik, 1 Mar 2003, In: Journal of Pathology. 199, 3, p. 378-86 9 p.

    Research output: Contribution to journal › Journal article › Research

  4. Published

    Longitudinal study of serum placental GH in 455 normal pregnancies: correlation to gestational age, fetal gender, and weight

    Chellakooty, M., Skibsted, L., Skouby, Sven O., Andersson, A., Petersen, J. H., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2002, In: Journal of Clinical Endocrinology and Metabolism. 87, 6, p. 2734-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Low Testosterone: A Risk Marker Rather Than a Risk Factor for Type 2 Diabetes

    Holmboe, S. A., Jensen, T. K., Linneberg, Allan René, Scheike, Thomas, Thuesen, B. H., Skakkebæk, Niels Erik, Juul, Anders & Andersson, A. M., Aug 2016, In: The Journal of Clinical Endocrinology & Metabolism. 101, 8, p. 3180-3190 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study

    Hagen, C. P., Vestergaard, S., Juul, Anders, Skakkebæk, Niels Erik, Andersson, A., Main, Katharina Maria, Hjøllund, N. H., Ernst, E., Bonde, Jens Peter, Anderson, R. A. & Jensen, T. K., 2012, In: Fertility and Sterility. 98, 6, p. 1602-8.e2

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Low semen volume in 47 adolescents and adults with 47,XXY Klinefelter or 46,XX male syndrome

    Aksglaede, L., Jørgensen, N., Skakkebæk, Niels Erik & Juul, Anders, 2008, In: International Journal of Andrology. 32, 4, p. 376-84 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study

    Wohlfahrt-Veje, C., Main, Katharina Maria, Schmidt, I. M., Boas, M., Jensen, T. K., Grandjean, P., Skakkebæk, Niels Erik & Andersen, H. R., 1 Jan 2011, In: Environmental Health. 10, p. 79

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility

    Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Buck Louis, G. M., Toppari, J., Andersson, A., Eisenberg, M. L., Jensen, T. K., Jørgensen, N., Swan, S. H., Sapra, K. J., Ziebe, S., Priskorn, L. & Juul, Anders, Jan 2016, In: Physiological Reviews. 96, 1, p. 55-97 43 p.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union

    Hauser, R., Skakkebæk, Niels Erik, Hass, U., Toppari, J., Juul, Anders, Andersson, A. M., Kortenkamp, A., Heindel, J. J. & Trasande, L., Apr 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 4, p. 1267-77 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Male reproductive health and environmental xenoestrogens

    Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jégou, B., Jensen, T. K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J. A., Meyer, O., Müller, J., Rajpert-De Meyts, E., Scheike, T., Sharpe, R., Sumpter, J. & Skakkebæk, Niels Erik, 1 Aug 1996, In: Environmental Health Perspectives. 104 Suppl 4, p. 741-803 63 p.

    Research output: Contribution to journal › Journal article › Research

  12. Published

    Many putative endocrine disruptors inhibit prostaglandin synthesis

    Kristensen, D. M., Skalkam, M. L., Audouze, K. M. L., Lesné, L., Desdoits-Lethimonier, C., Frederiksen, H., Brunak, Søren, Skakkebæk, Niels Erik, Jégou, B., Hansen, Jacob B., Junker, S. & Leffers, H., 1 Apr 2011, In: Environmental Health Perspectives. 119, 4, p. 534-41 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects

    Rasmussen, M. H., Hvidberg, A., Juul, Anders, Main, Katharina Maria, Gotfredsen, A., Skakkebæk, Niels Erik, Hilsted, J. & Skakkebae, N. E., 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 4, p. 1407-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Maternal exposure to UV filters: Associations with maternal thyroid hormones, IGF-I/IGFBP3 and birth outcomes

    Krause, M., Frederiksen, H., Sundberg, K., Jørgensen, Finn Stener, Jensen, L. N., Nørgaard, P., Jørgensen, C., Ertberg, P., Petersen, Jørgen Holm, Feldt-Rasmussen, Ulla, Juul, Anders, Drzewiecki, K. T., Skakkebæk, Niels Erik & Andersson, A. M., 1 Feb 2018, In: Endocrine Connections. 7, 2, p. 334-346 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Maternal phthalate exposure during pregnancy and testis function of young adult sons

    Henriksen, L. S., Frederiksen, H., Jørgensen, N., Juul, Anders, Skakkebæk, Niels Erik, Toppari, J., Petersen, Jørgen Holm & Main, Katharina Maria, 2023, In: Science of the Total Environment. 871, 12 p., 161914.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs

    Lind, D. V., Main, Katharina Maria, Kyhl, H. B., Kristensen, D. M., Toppari, J., Andersen, H. R., Skovsager Andersen, M., Skakkebæk, Niels Erik & Jensen, T. K., 2017, In: Human Reproduction. 32, 1, p. 223-231 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

    Rehfeld, Anders Aagaard, Palme, D. L. E., Almstrup, Kristian, Juul, Anders & Skakkebæk, Niels Erik, 2019, In: Journal of Visualized Experiments. 145, p. e59212

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

    Rehfeld, A., Egeberg Palme, D. L., Almstrup, K., Juul, Anders & Skakkebæk, Niels Erik, 1 Mar 2019, In: Journal of visualized experiments : JoVE. 145, 9 p., e59212.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Mere Testikelkræft og dårlig sædkvalitet

    Skakkebæk, Niels Erik, 2008, In: Tidsskrift for Den norske lægeforening. 128, p. 554-554

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Metabolic effects of GH: a rationale for continued GH treatment of GH-deficient adults after cessation of linear growth.

    Juul, Anders, Jørgensen, J., Christiansen, J., Müller, J. & Skakkebæk, Niels Erik, 1995, In: Hormone Research. p. 64-72 8 p.

    Research output: Contribution to journal › Review › Research

  21. Published

    Metabolic effects of long-term GH deficiency and GH replacement

    Christiansen, J., Jørgensen, J., Müller, J. & Skakkebæk, Niels Erik, 2013, Clinical Issues in growth disorders: Evaluation, diagnosis and therapy. Publishing House, Ltd., Europe, p. 163-170 7 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  22. Published

    Metabolism of phthalates in humans

    Frederiksen, H., Skakkebæk, Niels Erik & Andersson, A., 1 Jul 2007, In: Molecular Nutrition & Food Research. 51, 7, p. 899-911 13 p.

    Research output: Contribution to journal › Journal article › Research

  23. Published

    Natural history of seminiferous tubule degeneration in Klinefelter syndrome

    Aksglaede, L., Wikström, A. M., Rajpert-De Meyts, E., Dunkel, L., Skakkebæk, Niels Erik & Juul, Anders, 2006, In: Human Reproduction Update. 12, 1, p. 39-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Nedsatte serum koncentrationer af insulin-like growth factor hos patienter med cystisk fibrose

    Mosfeldt-Laursen, E., Juul, Anders, Lanng, S., Højby, N., Koch, C., Müller, J. & Skakkebæk, Niels Erik, 1996, In: Ugeskrift for Laeger. 158, 38, p. 5300-5302 2 p.

    Research output: Contribution to journal › Journal article › Research

  25. Published

    Nervous system drugs taken by future fathers and birth defects in offspring: a prospective registry-based cohort study

    Wensink, M., Lu, Y., Tian, L., Jensen, T. K., Skakkebæk, Niels Erik, Lindahl-Jacobsen, R. & Eisenberg, M., 2022, In: BMJ Open. 12, 3, 8 p., e053946.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

    Jørgensen, A., Macdonald, J., Nielsen, J. E., Kilcoyne, K. R., Perlman, S., Lundvall, L., Langhoff Thuesen, L., Hare, Kristine Juul, Frederiksen, H., Andersson, A., Skakkebæk, Niels Erik, Juul, Anders, Sharpe, R. M., Rajpert-De Meyts, E. & Mitchell, R. T., 13 Nov 2018, In: Cell Reports. 25, 7, p. 1924-1937.e4

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Normal reference ranges for semen quality and their relations to fecundity

    Skakkebæk, Niels Erik, 1 Jan 2010, In: Asian Journal of Andrology. 12, 1, p. 95-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres

    Kristensen, D. M., Nielsen, J. E., Kalisz, M., Dalgaard, M. D., Audouze, K., Larsen, M. E., Jacobsen, G. K., Horn, T., Brunak, S., Skakkebaek, N. E., Leffers, H., Kristensen, D. M., Nielsen, J. E., Kalisz, M., Dalgaard, M. D., Audouze, K. M. L., Larsen, M. E., Jacobsen, G. K., Horn, T., Brunak, S. & 2 others, Skakkebæk, Niels Erik & Leffers, H., 1 Nov 2010, In: Molecular Human Reproduction. 16, 11, p. 835-45 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Onset of the release of spermatozia (supermarche) in boys in relation to age, testicular growth, pubic hair, and height

    Nielsen, C. T., Skakkebæk, Niels Erik, Richardson, D. W., Darling, J. A. B., Hunter, W. M., Jørgensen, M., Nielsen, A., Ingerslev, O., Keiding, N. & Müller, J., 1 Mar 1986, In: Journal of Clinical Endocrinology and Metabolism. 62, 3, p. 532-535 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Optimised detection of germ cell neoplasia in situ in contralateral biopsy reduces the risk of second testis cancer

    Rajpert-De Meyts, E., Jørgensen, N., Petersen, Jørgen Holm, Almstrup, Kristian, Aksglaede, L., Lauritsen, J., Rørth, M., Daugaard, G. & Skakkebæk, Niels Erik, 2022, In: BJU International. 130, 5, p. 646-654 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development

    Kristensen, D. M., Sonne, Si Brask, Ottesen, A. M., Perrett, R. M., Nielsen, J. E., Almstrup, Kristian, Skakkebæk, Niels Erik, Leffers, H. & Meyts, E. R., 2008, In: Molecular and Cellular Endocrinology. 288, 1-2, p. 111-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Origin of testicular germ cell neoplasia: The role of sex chromosomes

    Rajpert-De Meyts, E., Ottesen, A. M., Høi-Hansen, Christina Engel, Sonne, Si Brask, Leffers, H. & Skakkebæk, Niels Erik, 1 Jan 2007, The Y Chromosome and Male Germ Cell Biology in Health and Diseases. World Scientific Publishing Co., p. 289-308 20 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  33. Published

    PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men

    Joensen, Ulla Nordström, Veyrand, B., Antignac, J. P., Jensen, Martin Blomberg, Petersen, Jørgen Holm, Marchand, P., Skakkebæk, Niels Erik, Andersson, A. M., Le Bizec, B. & Jørgensen, N., Mar 2013, In: Human Reproduction. 28, 3, p. 599-608 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Paracetamol Use During Pregnancy - A Call for Precautionary Action

    Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C., Andrade, A. M., Olsen, J., Jensen, Rigmor Højland, Mitchell, R. T., Skakkebæk, Niels Erik, Jégou, B. & Kristensen, D. M., 2022, In: Obstetrical and Gynecological Survey. 77, 3, p. 133-134 2 p.

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    Paracetamol use during pregnancy — a call for precautionary action

    Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C., Andrade, A. M., Olsen, J., Jensen, Rigmor Højland, Mitchell, R. T., Skakkebæk, Niels Erik, Jégou, B. & Kristensen, D. M., 2021, In: Nature Reviews Endocrinology. 17, p. 757–766 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  36. Published

    Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

    Andersen, H. R., Veje, C. W., Dalgård, C., Christiansen, L. T., Main, Katharina Maria, Nellemann, C. L., Murata, K., Jensen, T. K., Skakkebæk, Niels Erik & Grandjean, P., 2012, In: P L o S One. 7, 5, p. e36830

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case-Control Study

    Togawa, K., Le Cornet, C., Feychting, M., Tynes, T., Pukkala, E., Hansen, J., Olsson, A., Dalton, S. O., Nordby, K., Uuksulainen, S., Wiebert, P., Woldbæk, T., Skakkebæk, Niels Erik, Fervers, B. & Schüz, J., Oct 2016, In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 25, 10, p. 1426-1434 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)

    Olsson, A., Togawa, K., Schüz, J., Le Cornet, C., Fervers, B., Oksbjerg Dalton, S., Pukkala, E., Maria Feychting, M. F., Skakkebæk, Niels Erik & Hansen, J., 2018, In: Scandinavian Journal of Work, Environment & Health. 44, 6, p. 658-669

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden

    Corbin, S., Togawa, K., Schüz, J., Le Cornet, C., Fervers, B., Feychting, M., Wiebert, P., Hansen, J., Dalton, Susanne Oksbjerg, Kjærheim, K., Nordby, K. C., Østrem, R. S., Skakkebæk, Niels Erik, Uuksulainen, S., Pukkala, E. & Olsson, A., 2022, In: International Archives of Occupational and Environmental Health. 95, p. 1243–1253

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Pathogenesis of germ cell neoplasia in testicular dysgenesis and disorders of sex development

    Jørgensen, A., Lindhardt Johansen, M., Juul, Anders, Skakkebæk, Niels Erik, Main, Katharina Maria & Rajpert-De Meyts, E., Sep 2015, In: Seminars in Cell and Developmental Biology. 45, p. 124-37 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Pathogenesis of testicular carcinoma in situ and germ cell cancer: still more questions than answers

    Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 1 Aug 2011, In: International Journal of Andrology. 34, 4 Pt 2, p. e2-6

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming

    Almstrup, H. K., Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 2012, Perinatal Programming: The State of the Art. Plagemann, A. (ed.). De Gruyter, p. 219-228 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  43. Published

    Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming

    Almstrup, Kristian, Meyts, E. R. D. & Skakkebæk, Niels Erik, 30 Nov 2011, Perinatal Programming: The State of the Art. Walter de Gruyter GmbH and Co. KG, p. 219-228 10 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  44. Published

    Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study

    Nassan, F. L., Coull, B. A., Gaskins, A. J., Williams, M. A., Skakkebæk, Niels Erik, Ford, J. B., Ye, X., Calafat, A. M., Braun, J. M. & Hauser, R., 2017, In: Environmental Health Perspectives. 125, 8, 11 p., 087012.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Pilocarpine iontophoresis test: an index of physiological sweat secretion?

    Hjortskov, N., Jepsen, L., Nielsen, B., Juul, Anders & Skakkebæk, Niels Erik, 1995, In: Clinical physiology (Oxford, England). 15, 4, p. 409-14 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Pituitary–gonadal hormones associated with respiratory failure in men and women hospitalized with COVID-19: an observational cohort study

    Clausen, C. L., Johannsen, T. H., Skakkebæk, Niels Erik, Frederiksen, H., Ryrsø, C. K., Dungu, A. M., Hegelund, M. H., Faurholt-Jepsen, D., Krogh-Madsen, Rikke, Lindegaard, Birgitte, Linneberg, Allan René, Kårhus, L. L., Juul, Anders & Benfield, Thomas, 2023, In: Endocrine Connections. 12, 1, e220444.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone

    Blum, W. F., Englaro, P., Hanitsch, S., Juul, Anders, Hertel, N., Müller, J., Skakkebæk, Niels Erik, Heiman, M. L., Birkett, M., Attanasio, A. M., Kiess, W. & Rascher, W., 1997, In: Journal of Clinical Endocrinology and Metabolism. 82, 9, p. 2904-10 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Polychlorinated dibenzo-p-dioxins, furans, and biphenyls (PCDDs/PCDFs and PCBs) in breast milk and early childhood growth and IGF1

    Wohlfahrt-Veje, C., Audouze, K., Brunak, Søren, Antignac, J. P., le Bizec, B., Juul, Anders, Skakkebæk, Niels Erik & Main, Katharina Maria, 2014, In: Reproduction. 147, 4, p. 391-399 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Poor semen quality may contribute to recent decline in fertility rates

    Jensen, T. K., Carlsen, E., Jørgensen, N., Berthelsen, J. G., Keiding, N., Christensen, K., Petersen, Jørgen Holm, Knudsen, L. B. & Skakkebæk, Niels Erik, 2002, In: Human Reproduction. 17, 6, p. 1437-40 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Populations, decreasing fertility, and reproductive health

    Skakkebæk, Niels Erik, Jørgensen, N., Andersson, A., Juul, Anders, Main, Katharina Maria, Jensen, T. K. & Toppari, J., 13 Apr 2019, In: Lancet Oncology. 393, 10180, p. 1500-1501 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

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ID: 35319116