Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    45,X/46,XY mosaicism: phenotypic characteristics, growth, and reproductive function--a retrospective longitudinal study

    Lindhardt Johansen, M., Hagen, C. P., Rajpert-De Meyts, E., Kjærgaard, S., Petersen, B. L., Skakkebæk, Niels Erik, Main, Katharina Maria & Juul, Anders, 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 8, p. E1540-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management

    Aksglaede, L., Link, K., Giwercman, A., Jørgensen, N., Skakkebæk, Niels Erik & Juul, Anders, 2013, In: American Journal of Medical Genetics. Part C: Seminars in Medical Genetics. 163, 1, p. 55-63 9 p.

    Research output: Contribution to journal › Journal article › Research

  3. Published

    In vitro investigation of endocrine disrupting effects of pesticides on Ca2+-signaling in human sperm cells through actions on the sperm-specific and steroid-activated CatSper Ca2+-channel

    Birch, Michala Rosa, Johansen, M., Skakkebæk, Niels Erik, Andersson, A. & Rehfeld, Anders Aagaard, 2022, In: Environment International. 167, 15 p., 107399.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A Brief Review of the Link between Environment and Male Reproductive Health: Lessons from Studies of Testicular Germ Cell Cancer

    Skakkebæk, Niels Erik, 2016, In: Hormone Research in Paediatrics. 86, 4, p. 240-246 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    A controlled study on serum insulin-like growth factor-I and urinary excretion of growth hormone in fibromyalgia

    Jacobsen, S., Main, Katharina Maria, Danneskiold-Samsøe, B. & Skakkebæk, Niels Erik, 1 Jun 1995, In: Journal of Rheumatology. 22, 6, p. 1138-40 3 p.

    Research output: Contribution to journal › Journal article › Research

  6. Published

    A crossover-crossback prospective study of dibutyl-phthalate exposure from mesalamine medications and semen quality in men with inflammatory bowel disease

    Nassan, F. L., Coull, B. A., Skakkebæk, Niels Erik, Williams, M. A., Dadd, R., Mínguez-Alarcón, L., Krawetz, S. A., Hait, E. J., Korzenik, J. R., Moss, A. C., Ford, J. B. & Hauser, R., Oct 2016, In: Environment International. 95, p. 120-30 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    A crossover-crossback prospective study of dibutyl-phthalate exposure from mesalamine medications and serum reproductive hormones in men

    Nassan, F. L., Coull, B. A., Skakkebæk, Niels Erik, Andersson, A., Williams, M. A., Mínguez-Alarcón, L., Krawetz, S. A., Hall, J. E., Hait, E. J., Korzenik, J. R., Ford, J. B., Moss, A. C. & Hauser, R., 2018, In: Environmental Research. 160, p. 121-131 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A history of cryptorchidism is associated with impaired testicular function in early adulthood: a cross-sectional study of 6376 men from the general population

    Koch, T., Hansen, A. H., Priskorn, L., Petersen, Jørgen Holm, Carlsen, E., Main, Katharina Maria, Skakkebæk, Niels Erik & Jørgensen, N., 2020, In: Human Reproduction. 35, 8, p. 1765-1780 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth

    Chellakooty, M., Vangsgaard, K., Larsen, T., Scheike, T., Falck-Larsen, J., Legarth, J., Andersson, A. M., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 1 Jan 2004, In: Journal of Clinical Endocrinology and Metabolism. 89, 1, p. 384-91 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples

    Nielsen, J. E., Kristensen, D. M., Almstrup, Kristian, Jørgensen, A., Olesen, I. A., Jacobsen, G. K., Horn, T., Skakkebæk, Niels Erik, Leffers, H., Rajpert-De Meyts, E. & Jacobsen, G., 2012, In: Andrologia. p. 78-85 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding

    Chellakooty, M., Juul, A., Boisen, K. A., Damgaard, I. N., Kai, C. M., Schmidt, I. M., Petersen, Jørgen Holm, Skakkebæk, Niels Erik & Main, K. M., 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 820-826 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    A subfertile patient diagnosed with testicular carcinoma in situ by immunocytological staining for AP-2γ in semen samples: Case report

    Høi-Hansen, Christina Engel, Rajpert-De Meyts, E., Carlsen, E., Almstrup, Kristian, Leffers, H. & Skakkebæk, Niels Erik, Mar 2005, In: Human Reproduction. 20, 3, p. 579-582 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome (SRY)-positive 46,XX karyotypes

    Aksglaede, L., Skakkebæk, Niels Erik & Juul, Anders, 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 1, p. 169-176 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Abundance of DLK1, differential expression of CYP11B1, CYP21A2 and MC2R, and lack of INSL3 distinguish testicular adrenal rest tumours from Leydig cell tumours

    Lottrup, G., Nielsen, J. E., Skakkebæk, Niels Erik, Juul, Anders & Rajpert-De Meyts, E., Apr 2015, In: European Journal of Endocrinology. 172, 4, p. 491-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Acquired cryptorchidism is frequent in infancy and childhood

    Wohlfahrt-Veje, C., Boisen, K. A., Boas, M., Damgaard, I. N., Kai, C. M., Schmidt, I. M., Chellakooty, M., Suomi, A., Toppari, J., Skakkebæk, Niels Erik & Main, Katharina Maria, 2009, In: International Journal of Andrology. 32, 4, p. 423-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Adult Growth Hormone Deficiency

    Jørgensen, J., Müller, J., Wolthers, T., Vahn, N., Juul, Anders & Skakkebæk, Niels Erik, 1994, In: Hormone Research. 42, p. 235-241 6 p.

    Research output: Contribution to journal › Review › Research

  17. Published

    Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'

    Andersson, A., Jørgensen, N., Main, Katharina Maria, Toppari, J., Rajpert-De Meyts, E., Leffers, H., Juul, Anders, Jensen, T. K. & Skakkebæk, Niels Erik, 2008, In: International Journal of Andrology. 31, 2, p. 74-80 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Adverse trends in male reproductive health and decreasing fertility rates

    Priskorn, L., Holmboe, S., Jørgensen, N., Andersson, A., Almstrup, Kristian, Toppari, J. & Skakkebæk, Niels Erik, 2012, In: Animal Reproduction Science. 31, 2, p. 760-771 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend

    Juul, Anders, Magnusdottir, S., Scheike, T., Prytz, S. & Skakkebæk, Niels Erik, 1 Dec 2007, In: International Journal of Andrology. 30, 6, p. 537-42 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    An audit of the insulin-tolerance test in 255 patients with pituitary disease

    Lange, M., Svendsen, Ole Lander, Skakkebæk, Niels Erik, Müller, J., Juul, Anders, Schmiegelow, M. & Feldt-Rasmussen, Ulla, 2002, In: European Journal of Endocrinology. 147, 1, p. 41-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    An update on semen quality among young Finnish men and comparison with Danish data

    Rodprasert, W., Virtanen, H. E., Sadov, S., Perheentupa, A., Skakkebæk, Niels Erik, Jørgensen, N. & Toppari, J., 2019, In: Andrology. 7, 1, p. 15-23 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Analysis of cell-type-specific gene expression during mouse spermatogenesis

    Almstrup, Kristian, Nielsen, J. E., Hansen, M. A., Tanaka, M., Skakkebæk, Niels Erik & Leffers, H., Jun 2004, In: Biology of Reproduction. 70, 6, p. 1751-1761 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Analysis of gene expression in normal and neoplastic human testis: new roles of RNA

    Novotny, G. W., Nielsen, J. E., Sonne, Si Brask, Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Leffers, H. & Sonne, Si Brask, 2007, In: International Journal of Andrology. 30, 4, p. 316-327

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte

    Sonne, Si Brask, Almstrup, Kristian, Dalgaard, M., Juncker, A. S., Edsgard, D., Ruban, L., Harrison, N. J., Schwager, C., Abdollahi, A., Huber, P. E., Brunak, Søren, Gjerdrum, L. M., Moore, H. D., Andrews, P. W., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 15 Jun 2009, In: Current Cancer Research. 69, 12, p. 5241-50 10 p.

    Research output: Contribution to journal › Journal article › Research

  25. Published

    Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex-reversion in a 46,XY female

    Müller, J., Schwartz, M. & Skakkebæk, Niels Erik, 1 Jul 1992, In: Journal of Clinical Endocrinology and Metabolism. 75, 1, p. 331-3 3 p.

    Research output: Contribution to journal › Journal article › Research

  26. Published

    Androgens and the ageing male

    Juul, Anders & Skakkebæk, Niels Erik, 2002, In: Human Reproduction Update. 8, 5, p. 423-33 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Anogenital distance as a phenotypic signature through infancy

    Priskorn, L., Petersen, Jørgen Holm, Jørgensen, N., Kyhl, H. B., Andersen, M. S., Main, Katharina Maria, Andersson, A., Skakkebæk, Niels Erik & Jensen, T. K., 2018, In: Pediatric Research. 83, 3, p. 573-579 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population

    Priskorn, L., Bang, A. K., Nordkap, L., Krause, M., Mendiola, J., Jensen, T. K., Juul, Anders, Skakkebæk, Niels Erik, Swan, S. H. & Jørgensen, Niklas Rye, 1 Jan 2019, In: Human reproduction (Oxford, England). 34, 1, p. 12-24 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Antioxidanter og mandlig subfertilitet--en gennemgang af et Cochranereview

    Jensen, T. K., Skakkebæk, Niels Erik, Jørgensen, N., Jensen, M. B. & Juul, Anders, 2011, In: Ugeskrift for Laeger. 173, 50, p. 3253-5 3 p.

    Research output: Contribution to journal › Comment/debate › Research

  30. Published

    Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method

    Courant, F., Aksglæde, L., Antignac, J., Monteau, F., Sørensen, K., Andersson, A., Skakkebæk, Niels Erik, Juul, Anders & Bizec, B. L., 1 Jan 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 82-92 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Association Between Use of Marijuana and Male Reproductive Hormones and Semen Quality: A Study Among 1,215 Healthy Young Men

    Gundersen, T. D., Jørgensen, N., Andersson, A., Bang, A. K., Nordkap, L., Skakkebæk, Niels Erik, Priskorn, L., Juul, Anders & Jensen, T. K., 2015, In: American Journal of Epidemiology. 182, 6, p. 473-81 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures

    Krysiak-Baltyn, K., Toppari, J., Skakkebæk, Niels Erik, Jensen, T. S., Virtanen, H. E., Schramm, K., Shen, H., Vartiainen, T., Kiviranta, H., Taboureau, O., Audouze, K. M. L., Brunak, Søren & Main, Katharina Maria, 2012, In: International Journal of Andrology. 35, 3, p. 294-302 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Association between levels of persistent organic pollutants in adipose tissue and cryptorchidism in early childhood: a case-control study

    Koskenniemi, J. J., Virtanen, H. E., Kiviranta, H., Damgaard, I. N., Matomäki, J., Thorup, Jørgen Mogens, Hurme, T., Skakkebæk, Niels Erik, Main, Katharina Maria & Toppari, J., 2015, In: Environmental Health. 14, p. 78 1 p.

    Research output: Contribution to journal › Journal article › Research

  34. Published

    Association between organic dietary choice during pregnancy and hypospadias in offspring: a study of mothers of 306 boys operated on for hypospadias

    Christensen, J. S., Asklund, C., Skakkebæk, Niels Erik, Jørgensen, N., Andersen, H. R., Jørgensen, T. M., Olsen, L. H., Høyer, A. P., Moesgaard, J., Thorup, Jørgen Mogens & Jensen, T. K., Mar 2013, In: The Journal of Urology (Italian Edition). 189, 3, p. 1077-82 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis

    Skakkebæk, Niels Erik, Holm, M., Hoei-Hansen, C., Jørgensen, N. & Rajpert-De Meyts, E., 1 Jan 2003, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 111, 1, p. 1-9; discussion 9-11

    Research output: Contribution to journal › Journal article › Research

  36. Published

    Association of in Utero Persistent Organic Pollutant Exposure with Placental Thyroid Hormones

    Li, Z. M., Hernandez-Moreno, D., Main, Katharina Maria, Skakkebæk, Niels Erik, Kiviranta, H., Toppari, J., Feldt-Rasmussen, Ulla, Shen, H., Schramm, K. W. & De Angelis, M., 2018, In: Endocrinology. 159, 10, p. 3473-3481 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries

    Jensen, T. K., Jørgensen, N., Punab, M., Haugen, T. B., Suominen, J., Zilaitiene, B., Horte, A., Andersen, A., Carlsen, E., Magnus, Ø., Matulevicius, V., Nermoen, I., Vierula, M., Keiding, N., Toppari, J. & Skakkebæk, Niels Erik, 2004, In: American Journal of Epidemiology. 159, 1, p. 49-58 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer

    Jensen, Martin Blomberg, Leffers, H., Petersen, Jørgen Holm, Daugaard, G., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., 2008, In: Annals of Oncology. 19, 11, p. 1910-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta

    Virtanen, H. E., Koskenniemi, J. J., Sundqvist, E., Main, Katharina Maria, Kiviranta, H., Tuomisto, J. T., Tuomisto, J., Viluksela, M., Vartiainen, T., Skakkebæk, Niels Erik & Toppari, J., 2012, In: International Journal of Andrology. 35, 3, p. 283-93 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men

    Joensen, U. N., Jørgensen, N., Meldgaard, M., Frederiksen, H., Andersson, A., Menné, T., Johansen, Jeanne Duus, Carlsen, B. C., Stender, S., Szecsi, P. B., Skakkebæk, Niels Erik, De Meyts, E. R. & Thyssen, Jacob Pontoppidan, Apr 2014, In: Environmental Health Perspectives. 122, 4, p. 345-350 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Assumed non-persistent environmental chemicals in human adipose tissue; matrix stability and correlation with levels measured in urine and serum

    Artacho-Cordón, F., Arrebola, J. P., Nielsen, O., Hernández, P., Skakkebæk, Niels Erik, Fernández, M. F., Andersson, A. M., Olea, N. & Frederiksen, H., Jul 2017, In: Environmental Research. 156, p. 120-127 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Authors' reply

    Keiding, N. & Skakkebæk, Niels Erik, 26 Aug 1995, In: BMJ. 311, p. 570-570 1 p.

    Research output: Contribution to journal › Comment/debate › Research

  43. Published

    Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years

    Priskorn, L., Nordkap, L., Bang, A. K., Krause, M., Holmboe, S. A., Egeberg Palme, D. L., Winge, S. B., Mørup, N., Carlsen, E., Joensen, Ulla Nordström, Blomberg Jensen, M., Main, Katharina Maria, Juul, Anders, Skakkebæk, Niels Erik, Jensen, T. K. & Jørgensen, N., 2018, In: Human Reproduction. 33, 6, p. 998-1008 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Behandling og udredning af mandlig infertilitet og hypogonadisme

    Carlsen, E., Jørgensen, N., Juul, Anders & Skakkebæk, Niels Erik, 2005, In: Maanedsskrift for Praktisk Laegegerning. 83, p. 1239-49 10 p.

    Research output: Contribution to journal › Review › Research

  45. Published

    Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

    Rehfeld, Anders Aagaard, Andersson, A. M. & Skakkebæk, Niels Erik, 2020, In: Frontiers in Endocrinology. 11, 11 p., 324.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce Ca2+ Signals in Boar Sperm Cells

    Rehfeld, Anders Aagaard, Mendoza, N., Ausejo, R. & Skakkebæk, Niels Erik, 2020, In: Frontiers in Physiology. 11, p. 785

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS

    Frederiksen, H., Aksglaede, L., Sorensen, K., Nielsen, O., Main, Katharina Maria, Skakkebæk, Niels Erik, Juul, Anders & Andersson, A., 2013, In: International Journal of Hygiene and Environmental Health.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Bone mineral density is preserved in men with idiopathic infertility

    Antonio, L., Priskorn, L., Nordkap, L., Bang, A. K., Jensen, T. K., Skakkebæk, Niels Erik, Petersen, Jørgen Holm, Vanderschueren, D. & Jørgensen, N., 2020, In: Andrology. 8, 2, p. 315-322 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis

    Trasande, L., Zoeller, R. T., Hass, U., Kortenkamp, A., Grandjean, P., Myers, J. P., DiGangi, J., Hunt, P. M., Rudel, R., Sathyanarayana, S., Bellanger, M., Hauser, R., Legler, J., Skakkebæk, Niels Erik & Heindel, J. J., Jul 2016, In: Andrology. 4, 4, p. 565-572 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours

    Sonne, Si Brask, Hoei-Hansen, C. E., Nielsen, J. E., Herlihy, A. S., Andersson, A., Almstrup, Kristian, Daugaard, G., Skakkebæk, Niels Erik, Leffers, H., Rajpert-De Meyts, E., Sonne, S. B., Hoei-Hansen, C. E., Nielsen, J. E., Herlihy, A. S., Andersson, A., Almstrup, K., Daugaard, G., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2006, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 114, 7-8, p. 549-58 10 p.

    Research output: Contribution to journal › Journal article › Research

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