Maiken Nedergaard

Maiken Nedergaard

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    1. Published

      A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

      Ribeiro Xavier, A. L., Kress, B. T., Goldman, Steven Alan, Lacerda de Menezes, J. R. & Nedergaard, Maiken, 26 Aug 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 34, p. 11848-11861 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      A SPECT-based method for dynamic imaging of the glymphatic system in rats

      Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      A mesothelium divides the subarachnoid space into functional compartments

      Møllgård, Kjeld, Beinlich, Felix Ralf Michael, Kusk, P., Miyakoshi, L. M., Delle, Christine, Pla Requena, Virginia Teresa, Hauglund, Natalie Linea, Esmail, Tina, Rasmussen, Martin Kaag, Gomolka, Ryszard Stefan, Mori, Yuki & Nedergaard, Maiken, 2023, In: Science. 379, 6627, p. 84-885

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      A network model of glymphatic flow under different experimentally-motivated parametric scenarios

      Tithof, J., Boster, K. A. S., Bork, Peter Aleksander Rousing, Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2022, In: iScience. 25, 5, 24 p., 104258.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      A real-time in vivo clearance assay for quantification of glymphatic efflux

      Plá, V., Bork, Peter Aleksander Rousing, Harnpramukkul, A., Olveda, G., Ladrón-de-Guevara, A., Giannetto, M. J., Hussain, R., Wang, W., Kelley, D. H., Hablitz, L. M. & Nedergaard, Maiken, 2022, In: Cell Reports. 40, 11, 20 p., 111320.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life

      Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, Shen, Y., 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices

      Stæger, Frederik Filip Vinggaard, Mortensen, K. N., Nielsen, M. S. N., Sigurdsson, B., Kaufmann, L. K., Hirase, Hajime & Nedergaard, Maiken, 2020, In: Scientific Data. 7, 1, 7 p., 235.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      AMELIORATION OF GLYMPHATIC PATHWAY IS CRITICAL FOR LONG TERM RECOVERY FROM TRAUMATIC BRAIN INJURY

      Hussain, R., Wang, W., Cheetham-West, A. O., Sun, Q. & Nedergaard, Maiken, 2018, p. A204. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    9. Published

      Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization

      Monai, H., Koketsu, S., Shinohara, Y., Ueki, T., Kusk, P., Hauglund, Natalie Linea, Samson, A. J., Nedergaard, Maiken & Hirase, Hajime, 2021, In: Scientific Reports. 11, 1, 8150.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke

      Monai, H., Wang, X., Yahagi, K., Lou, N., Mestre, H., Xu, Q., Abe, Y., Yasui, M., Iwai, Y., Nedergaard, Maiken & Hirase, Hajime, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 22, p. 11010-11019 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Age- and glaucoma-induced changes to the ocular glymphatic system

      Wang, X., Delle, Christine, Peng, W., Pla Requena, Virginia Teresa, Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, Ting, Libby, R. T. & Nedergaard, Maiken, 2023, In: Neurobiology of Disease. 188, 9 p., 106322.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Air pollution, glymphatic impairment, and Alzheimer's disease

      Hussain, R., Graham, U., Elder, A. & Nedergaard, Maiken, 2023, In: Trends in Neurosciences. 46, 11, p. 901-911 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    13. Published

      Altered physiological brain variation in drug-resistant epilepsy

      Kananen, J., Tuovinen, T., Ansakorpi, H., Rytky, S., Helakari, H., Huotari, N., Raitamaa, L., Raatikainen, V., Rasila, A., Borchardt, V., Korhonen, V., LeVan, P., Nedergaard, Maiken & Kiviniemi, V., 2018, In: Brain and Behavior. 8, 9, p. 1-17 17 p., e01090.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      An ocular glymphatic clearance system removes beta-amyloid from the rodent eye

      Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Forstera, B., Peng, S., Shi, M., Ladron-de-Guevara, A., Delle, Christine, Sigurdsson, B., L R Xavier, Anna , Erturk, A., Libby, R. T., Chen, L., Thrane, A. S. & Nedergaard, Maiken, 2020, In: Science Translational Medicine. 12, 536, eaaw3210.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      An unnoticed player overseeing CSF flux

      Pla Requena, Virginia Teresa & Nedergaard, Maiken, 2022, In: Nature Cardiovascular Research. 1, 2 p.

      Research output: Contribution to journal › Comment/debate › Research

    16. Published

      Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system

      Li, Q., Aalling, Nadia, Förstera, B., Ertürk, A., Nedergaard, Maiken, Møllgård, Kjeld & L R Xavier, Anna , 2020, In: Fluids and Barriers of the CNS. 17, 15 p., 15.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Aquaporin-4-dependent glymphatic solute transport in the rodent brain

      Mestre, H., Hablitz, L. M., Xavier, A. L. R., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Rivera, R. M. C., Simon, M. J., Pike, M. M., Pla, V., Du, T., Kress, B. T., Wang, X., Plog, B. A., Thrane, A. S., Lundgaard, I., Abe, Y., Yasui, M. & 6 others, Thomas, J. H., Xiao, M., Hirase, Hajime, Asokan, A., Iliff, J. J. & Nedergaard, Maiken, 2018, In: eLife. 7, 31 p., :e40070.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow

      Bork, Peter Aleksander Rousing, Ladrón-De-Guevara, A., Christensen, A. H., Jensen, K. H., Nedergaard, Maiken & Bohr, T., 2023, In: Journal of the Royal Society Interface. 20, 204, 5 p., 20230050.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Astrocytes in chronic pain and itch

      Ji, R., Donnelly, C. R. & Nedergaard, Maiken, 2019, In: Nature Reviews Neuroscience. 20, 11, p. 667-685

      Research output: Contribution to journal › Review › Research › peer-review

    20. Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression

      Smith, N. A., Bekar, L. K. & Nedergaard, Maiken, 2020, In: Neurochemical Research. 45, 1, p. 100-108 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes

      Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice

      Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease

      Wang, M., Qin, C., Luo, X., Wang, J., Wang, X., Xie, M., Hu, J., Cao, J., Hu, T., Goldman, Steven Alan, Nedergaard, Maiken & Wang, W., 2019, In: Theranostics. 9, 15, p. 4474-4493 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

      Lundgaard, I., Wang, W., Eberhardt, A., Vinitsky, H. S., Reeves, B. C., Peng, S., Lou, N., Hussain, R. & Nedergaard, Maiken, 2018, In: Scientific Reports. 8, 1, 16 p., 2246.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice

      Giannetto, M., Xia, M., Stæger, Frederik Filip Vinggaard, Metcalfe, T., Vinitsky, H. S., Dang, J. A. M. L., L R Xavier, Anna , Kress, B. T., Nedergaard, Maiken & Hablitz, L. M., 2020, In: Scientific Reports. 10, 1, 8 p., 16073.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension

      Beaman, Emily Eufaula, Bonde, A. N., Larsen, S. M. U., Ozenne, Brice Maxime Hugues, Lohela, T. J., Nedergaard, Maiken, Gislason, Gunnar Hilmar, Knudsen, Gitte Moos & Holst, S. C., 2023, In: Brain. 146, 3, p. 1141–1151 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI

      Koundal, S., Liu, X., Sanggaard, S., Mortensen, K., Wardlaw, J., Nedergaard, Maiken, Benveniste, H. & Lee, H., 2019, In: Neuroscience. 404, p. 14-26

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Brain Segmentation in Rodent MR-Images Using Convolutional Neural Networks

      Sigurdsson, B., Darkner, Sune, Sommer, Stefan Horst, Mortensen, K. N., Sanggaard, S., Kostrikov, S. & Nedergaard, Maiken, 2018.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    29. Published

      Brain energetics during the sleep-wake cycle

      DiNuzzo, M. & Nedergaard, Maiken, Dec 2017, In: Current Opinion in Neurobiology. 47, p. 65-72 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    30. Published

      Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

      Raghunandan, A., Ladron-De-guevara, A., Tithof, J., Mestre, H., Du, T., Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2021, In: eLife. 10, 15 p., e65958.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      CSF space volumetry using 3D-CISS in Aqp4-deficient mice – quantitative analysis and technical advances

      Gomolka, Ryszard Stefan, Nedergaard, Maiken & Mori, Yuki, 2021, Book of Abstracts ESMRMB 2021 Online 38th Annual Scientific Meeting 7-9 October 2021. Springer, Vol. 34. p. S95-6 2 p. (Magnetic Resonance Materials in Physics, Biology, and Medicine; No. 34).

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

    32. Published

      Cannula Implantation into the Cisterna Magna of Rodents

      L R Xavier, Anna , Hauglund, Natalie Linea, Holstein-Rønsbo, Stephanie, Li, Q., Sanggaard, S., Lou, N., Lundgaard, I. & Nedergaard, Maiken, 2018, In: Journal of Visualized Experiments. 135, 6 p., e57378.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Cardiovascular brain impulses in Alzheimer's disease

      Rajna, Z., Mattila, H., Huotari, N., Tuovinen, T., Krüger, J., Holst, S. C., Korhonen, V., Remes, A. M., Seppänen, T., Hennig, J., Nedergaard, Maiken & Kiviniemi, V., 2021, In: Brain. 144, 7, p. 2214-2226 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas

      Grutzendler, J. & Nedergaard, Maiken, 2019, In: Trends in Neurosciences. 42, 8, p. 528-536 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    35. Published

      Cerebral Metabolic Changes During Sleep

      Aalling, Nadia, Nedergaard, Maiken & DiNuzzo, M., 1 Sep 2018, In: Current Neurology and Neuroscience Reports. 18, 9, 17 p., 57.

      Research output: Contribution to journal › Review › Research › peer-review

    36. Published

      Cerebral small vessel disease: A glymphopathy?

      Benveniste, H. & Nedergaard, Maiken, 2021, In: Current Opinion in Neurobiology. 72, p. 15-21 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

    37. Published

      Cerebrospinal fluid clearance in Alzheimer disease measured with dynamic PET

      De Leon, M. J., Li, Y., Okamura, N., Tsui, W. H., Saint-Louis, L. A., Glodzik, L., Osorio, R. S., Fortea, J., Butler, T., Pirraglia, E., Fossati, S., Kim, H. J., Carare, R. O., Nedergaard, Maiken, Benveniste, H. & Rusinek, H., 2017, In: Journal of Nuclear Medicine. 58, 9, p. 1471-1476 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Cerebrospinal fluid influx drives acute ischemic tissue swelling

      Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D. & 3 others, Hirase, Hajime, Mori, Yuki & Nedergaard, Maiken, 2020, In: Science. 367, 6483, 8 p., eaaw7462.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

      Du, T., Mestre, H., Kress, B. T., Liu, G., Sweeney, A. M., Samson, A. J., Rasmussen, M. K., Mortensen, K. N., Bork, P. A. R., Peng, W., Olveda, G. E., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Hirase, H. & 2 others, Mori, Yuki & Nedergaard, Maiken, 2022, In: Brain. 145, 2, p. 787–797 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Changes in the composition of brain interstitial ions control the sleep-wake cycle

      Ding, F., O'Donnell, J., Xu, Q., Kang, N., Goldman, N. & Nedergaard, Maiken, 29 Apr 2016, In: Science. 352, 6285, p. 550-555 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Changes in visual processing during progression of Tau accumulation and neurodegeneration in a mouse model of human tauopathy

      Parka, A., Nedergaard, Maiken, Sotty, F. & Laursen, B., 2021, In: Investigative Ophthalmology & Visual Science. 62, 8, 3 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    42. Published

      Circadian control of brain glymphatic and lymphatic fluid flow

      Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, Frederik Filip Vinggaard, Metcalfe, T., Nguyen, R., Benrais, A. & Nedergaard, Maiken, 2020, In: Nature Communications. 11, 1, 4411.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Cisterna magna injection in rats to study glymphatic function

      Ramos, M., Burdon Bechet, N., Battistella, R., Pavan, C., L R Xavier, Anna , Nedergaard, Maiken & Lundgaard, I., 2019, Astrocytes: Methods and Protocols. Di Benedetto, B. (ed.). Humana Press, p. 97-104 8 p. (Methods in Molecular Biology, Vol. 1938).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    44. Published

      Cleaning the sleeping brain – the potential restorative function of the glymphatic system

      Hauglund, Natalie Linea, Pavan, C. & Nedergaard, Maiken, 1 Jun 2020, In: Current Opinion in Physiology. 15, 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses

      Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, Maiken, Kaila, K., Voipio, J. & MacAulay, Nanna, Apr 2014, In: Glia. 62, 4, p. 608-22 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice

      Rasmussen, R., Nicholas, E., Petersen, Nicolas Caesar, Dietz, Andrea Grostøl, Xu, Q., Sun, Q. & Nedergaard, Maiken, 2019, In: Cell Reports. 28, 5, p. 1182-1194 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Could dexmedetomidine be repurposed as a glymphatic enhancer?

      Persson, N. D. Å., Uusalo, P., Nedergaard, Maiken, Lohela, T. J. & Lilius, T. O., 2022, In: Trends in Pharmacological Sciences. 43, 12, p. 1030-1040 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    48. Published

      Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ISMRM Imaging Neurofluids Study group” Workshop in Rome

      Agarwal, N., Lewis, L. D., Hirschler, L., Rivera, L. R., Naganawa, S., Levendovszky, S. R., Ringstad, G., Klarica, M., Wardlaw, J., Iadecola, C., Hawkes, C., Carare, R. O., Wells, J., Bakker, E. N. T. P., Kurtcuoglu, V., Bilston, L., Nedergaard, M., Mori, Y., Stoodley, M., Alperin, N. & 2 others, de Leon, M. & van Osch, M. J. P., 2024, In: Journal of Magnetic Resonance Imaging. 59, 2, 19 p.

      Research output: Contribution to journal › Review › Research › peer-review

    49. Published

      DNase treatment prevents CSF block in early experimental pneumococcal meningitis

      Pavan, C., L R Xavier, Anna , Ramos, M., Fisher, J., Kritsilis, M., Linder, A., Bentzer, P., Nedergaard, Maiken & Lundgaard, I., 2021, In: Annals of Neurology. 90, 4, p. 653-669 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Defining novel functions for cerebrospinal fluid in ALS pathophysiology

      Ng Kee Kwong, K. C., Mehta, A. R., Nedergaard, Maiken & Chandran, S., 2020, In: Acta Neuropathologica Communications. 8, 1, 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

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