Mads Gyrd-Hansen

Mads Gyrd-Hansen

Professor

ORCID: 0000-0001-5641-5019

Publication year:
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  1. 2024
  2. E-pub ahead of print

    Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response

    Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, Mads, Murphy, D. J., Huang, D. T., Zanivan, S. & Tait, S. W., 9 Feb 2024, (E-pub ahead of print) In: The EMBO Journal.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2022
  4. Published

    Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1

    Peng, R., Wang, Chris Kedong, Wang-Kan, X., Idorn, M., Kjær, M., Zhou, F. Y., Fiil, Berthe Katrine, Timmermann, F., Orozco, S. L., McCarthy, J., Leung, C. S., Lu, X., Bagola, K., Rehwinkel, J., Oberst, A., Maelfait, J., Paludan, S. R. & Gyrd-Hansen, Mads, 2022, In: EMBO Reports. 2022, 23, e55839.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2021
  6. Published

    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

    Elliott, P. R., Leske, D., Wagstaff, J., Schlicher, L., Berridge, G., Maslen, S., Timmermann, F., Ma, B., Fischer, R., Freund, S. M. V., Komander, D. & Gyrd-Hansen, Mads, 2021, In: Cell Reports. 37, 1, 25 p., 109777.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The Met1-linked ubiquitin machinery in inflammation and infection

    Fiil, Berthe Katrine & Gyrd-Hansen, Mads, 2021, In: Cell Death and Differentiation. 28, p. 557–569

    Research output: Contribution to journal › Review › Research › peer-review

  8. Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

    Klaessens, S., Stroobant, V., Hoffmann, D., Gyrd-Hansen, Mads, Pilotte, L., Vigneron, N., De Plaen, E. & Van den Eynde, B. J., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 23, p. e2022447118

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling

    Nikhar, S., Siokas, I., Schlicher, L., Lee, S., Gyrd-Hansen, Mads, Degterev, A. & Cuny, G. D., 2021, In: European Journal of Medicinal Chemistry. 215, 113252.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. RIPK2 NODs to XIAP and IBD

    Topal, Y. & Gyrd-Hansen, Mads, 2021, In: Seminars in Cell and Developmental Biology. 109, p. 144-150 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  11. 2020

  12. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

    Bodda, C., Reinert, L. S., Fruhwürth, S., Richardo, T., Sun, C., Zhang, B., Kalamvoki, M., Pohlmann, A., Mogensen, T. H., Bergström, P., Agholme, L., O'Hare, P., Sodeik, B., Gyrd-Hansen, Mads, Zetterberg, H. & Paludan, S. R., 2020, In: The Journal of Experimental Medicine. 217, 7

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Fenech, E. J., Lari, F., Charles, P. D., Fischer, R., Laétitia-Thézénas, M., Bagola, K., Paton, A. W., Paton, J. C., Gyrd-Hansen, Mads, Kessler, B. M. & Christianson, J. C., 2 Jul 2020, In: eLife. 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold

    Suebsuwong, C., Dai, B., Pinkas, D. M., Duddupudi, A. L., Li, L., Bufton, J. C., Schlicher, L., Gyrd-Hansen, Mads, Hu, M., Bullock, A. N., Degterev, A. & Cuny, G. D., 2020, In: European Journal of Medicinal Chemistry. 200, 21 p., 112417.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2018

  16. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

    Hrdinka, M., Schlicher, L., Dai, B., Pinkas, D. M., Bufton, J. C., Picaud, S., Ward, J. A., Rogers, C., Suebsuwong, C., Nikhar, S., Cuny, G. D., Huber, K. V., Filippakopoulos, P., Bullock, A. N., Degterev, A. & Gyrd-Hansen, Mads, 3 Sep 2018, In: The EMBO Journal. 37, 17

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

    Prabakaran, T., Bodda, C., Krapp, C., Zhang, B-C., Christensen, M. H., Sun, C., Reinert, L., Cai, Y., Jensen, S. B., Skouboe, M. K., Nyengaard, J. R., Thompson, C. B., Lebbink, R. J., Sen, G. C., van Loo, G., Nielsen, R., Komatsu, M., Nejsum, L. N., Jakobsen, M. R., Gyrd-Hansen, M. & 1 others, Paludan, S. R., 13 Apr 2018, In: The EMBO Journal. 37, 8, e97858.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2017

  19. All roads lead to ubiquitin

    Gyrd-Hansen, Mads, 2017, In: Cell Death and Differentiation. 24, 7, p. 1135-1136 2 p.

    Research output: Contribution to journal › Editorial › Research

  20. Cell scientist to watch - Mads Gyrd-Hansen

    Gyrd-Hansen, Mads, 2017, In: Journal of Cell Science. 130, 12, p. 1981-1983 3 p.

    Research output: Contribution to journal › Comment/debate › Research

  21. The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

    Hrdinka, M. & Gyrd-Hansen, Mads, 19 Oct 2017, In: Molecular Cell. 68, 2, p. 265-280 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  22. Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

    Schwerd, T., Pandey, S., Yang, H-T., Bagola, K., Jameson, E., Jung, J., Lachmann, R. H., Shah, N., Patel, S. Y., Booth, C., Runz, H., Düker, G., Bettels, R., Rohrbach, M., Kugathasan, S., Chapel, H., Keshav, S., Elkadri, A., Platt, N., Muise, A. M. & 8 others, Koletzko, S., Xavier, R. J., Marquardt, T., Powrie, F., Wraith, J. E., Gyrd-Hansen, Mads, Platt, F. M. & Uhlig, H. H., Jun 2017, In: Gut. 66, 6, p. 1060-1073 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2016

  24. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

    Elliott, P. R., Leske, D., Hrdinka, M., Bagola, K., Fiil, Berthe Katrine, McLaughlin, S. H., Wagstaff, J., Volkmar, N., Christianson, J. C., Kessler, B. M., Freund, S. M. V., Komander, D. & Gyrd-Hansen, Mads, 15 Sep 2016, In: Molecular Cell. 63, 6, p. 990-1005 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    OTULIN deficiency causes auto-inflammatory syndrome

    Fiil, Berthe Katrine & Gyrd-Hansen, Mads, Nov 2016, In: Cell Research. 26, 11, p. 1176-1177 2 p.

    Research output: Contribution to journal › Journal article › Commissioned

  26. CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

    Hrdinka, M., Fiil, Berthe Katrine, Zucca, M., Leske, D., Bagola, K., Yabal, M., Elliott, P. R., Damgaard, R. B., Komander, D., Jost, P. J. & Gyrd-Hansen, Mads, 29 Mar 2016, In: Cell Reports. 14, 12, p. 2846-58 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2015

  28. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

    Canning, P., Ruan, Q., Schwerd, T., Hrdinka, M., Maki, J. L., Saleh, D., Suebsuwong, C., Ray, S., Brennan, P. E., Cuny, G. D., Uhlig, H. H., Gyrd-Hansen, Mads, Degterev, A. & Bullock, A. N., 17 Sep 2015, In: Cell Chemical Biology. 22, 9, p. 1174-84 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Symptomatic Males and Female Carriers in a Large Caucasian Kindred with XIAP Deficiency

    Dziadzio, M., Ammann, S., Canning, C., Boyle, F., Hassan, A., Cale, C., Elawad, M., Fiil, Berthe Katrine, Gyrd-Hansen, Mads, Salzer, U., Speckmann, C. & Grimbacher, B., 25 Jul 2015, In: Journal of Clinical Immunology. 35, 5, p. 439-444 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

    Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H-J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L., Lowes, K. N. & 8 others, Murphy, J. M., Gyrd-Hansen, Mads, Parker, M. W., Hartland, E. L., Lew, A. M., Huang, D. C. S., Lessene, G. & Silke, J., 17 Mar 2015, In: Nature Communications. 6, 13 p., 6442.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2014

  32. A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency

    Ammann, S., Elling, R., Gyrd-Hansen, Mads, Dückers, G., Bredius, R., Burns, S. O., Edgar, J. D. M., Worth, A., Brandau, H., Warnatz, K., zur Stadt, U., Hasselblatt, P., Schwarz, K., Ehl, S. & Speckmann, C., 2014, In: Clinical and Experimental Immunology. 176, 3, p. 394-400 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Molecular basis and regulation of OTULIN-LUBAC interaction

    Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, Berthe Katrine, Keusekotten, K., Mailand, Niels, Freund, S. M. V., Gyrd-Hansen, Mads & Komander, D., 2014, In: Molecular Cell. 54, 3, p. 335-348 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Met1-linked Ubiquitination in Immune Signalling

    Fiil, Berthe Katrine & Gyrd-Hansen, Mads, Oct 2014, In: F E B S Journal. 81, 19, p. 4337-50 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

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