Laura Hyrup Møller
Pharmaceutical Physical and Analytical Chemistry
Universitetsparken 2, 2100 København Ø, 18, Building: 18-3-308
Primary fields of research
Application of drug delivery systems is a promising strategy for improvement of bioavailability and efficiency of a drug compound, or for targeting a specific site in the body. From early idea to final drug product, reliable analytical methods are crucial in order to characterize the drug formulation and the fate of the drug and delivery system in the human body. New drug delivery systems comprise new technologies and materials, in order to move the development of such drug designs forward, research within the analytical methodologies for characterization and quantification, are important.
I apply an advanced mass spectrometry (MS) based technology platform, comprising elemental and molecular mass spectrometry (ICP-MS and ESI-MS) combined with chromatographic separation by liquid chromatography (HPLC), size exclusion chromatography (SEC) or capillary electrophoresis (CE) and develop new analytical approaches for qualitative and quantitative characterization of drug formulations and delivery in vitro and in biological systems.
- Physicochemical and quantitative characterization of inorganic nanoparticle drug delivery systems in biological samples, in terms of size, size distribution, composition, stability, drug loading efficiency, release of drug from nanoparticle and biotransformation of nanoparticles using single-particle ICP-MS and hyphenated ICP-MS methods.
- Quantification of synthetic pharmaceutical peptides using selenium as an elemental label. Characterization of physicochemical properties, cell uptake, and degradation during cell-studies and in human plasma. Comparison of selenium-labelled peptide, fluorophore labelled peptide as well as native peptide.
Evaluation of Pharmaceutical Substances (Kvalitetsvurdering af Farmaceutiske Råvarer), Bachelor. Course responsible.
Supervision of master thesis students.