Jonas Sigurd Mortensen
Postdoc
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
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3,4-Bis(hydroxymethyl)hexane-1,6-diol-based Maltosides (HDMs) for Membrane-Protein Study: Importance of Detergent Rigidity-Flexibility Balance in Protein Stability
Lee, H. S., Das, M., Mahler, F., Ahmed, W., Wang, H., Mortensen, Jonas Sigurd, Hariharan, P., Ghani, L., Byrne, B., Guan, L., Loland, Claus Juul, Keller, S. & Chae, P. S., 2022, In: Chemistry - An Asian Journal. 17, 24, 9 p., e202200941.Research output: Contribution to journal › Journal article › Research › peer-review
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A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
Sadaf, A., Mortensen, Jonas Sigurd, Capaldi, S., Tikhonova, E., Hariharan, P., de Castro Ribeiro, O., Loland, Claus Juul, Guan, L., Byrne, B. & Chae, P. S., 1 Mar 2016, In: Chemical Science. 7, 3, p. 1933-1939 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability
Hussain, H., Helton, T., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Ehsan, M., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: Analyst. 143, 23, p. 5702-5710 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation
Hussain, H., Du, Y., Scull, N. J., Mortensen, Jonas Sigurd, Tarrasch, J., Bae, H. E., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 17 May 2016, In: Chemistry: A European Journal. 22, 21, p. 7068-7073 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability
Das, M., Du, Y., Mortensen, Jonas Sigurd, Bae, H. E., Byrne, B., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 11 Jul 2018, In: Chemistry - A European Journal. 24, 39, p. 9860-9868 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability
Bae, H. E., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Kumar, K. K., Ha, B., Das, M., Lee, H. S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemical Science. 10, 4, p. 1107-1116Research output: Contribution to journal › Journal article › Research › peer-review
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Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region
Das, M., Du, Y., Mortensen, Jonas Sigurd, Ribeiro, O., Hariharan, P., Guan, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemical Science. 2, p. 1169-1177 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties
Das, M., Du, Y., Ribeiro, O., Hariharan, P., Mortensen, Jonas Sigurd, Patra, D., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Journal of the American Chemical Society. 139, 8, p. 3072-3081Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability
Sadaf, A., Ramos, M., Mortensen, Jonas Sigurd, Du, Y., Bae, H. E., Munk, C. F., Hariharan, P., Byrne, B., Kobilka, B. K., Loland, Claus Juul, Guan, L. & Chae, P. S., 2019, In: ACS chemical biology. 14, 8, p. 1717-1726 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study
Sadaf, A., Du, Y., Santillan, C., Mortensen, Jonas Sigurd, Molist, I., Seven, A. B., Hariharan, P., Skiniotis, G., Loland, Claus Juul, Kobilka, B. K., Guan, L., Byrne, B. & Chae, P. S., 2017, In: Chemical Science. 8, 12, p. 8315-8324 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study
Das, M., Mahler, F., Hariharan, P., Wang, H., Du, Y., Mortensen, Jonas Sigurd, Patallo, E. P., Ghani, L., Glück, D., Lee, H. J., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K., Keller, S. & Chae, P. S., 2020, In: Journal of the American Chemical Society. 142, 51, p. 21382–21392 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.Research output: Contribution to journal › Journal article › Research › peer-review
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Foldable detergents for membrane protein study: Importance of detergent core flexibility in protein stabilization
Ghani, L., Kim, S., Wang, H., Lee, H. S., Mortensen, Jonas Sigurd, Katsube, S., Du, Y., Sadaf, A., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K., Im, W., Chae, P. S. & Ahmed, W., 2022, In: Chemistry: A European Journal. 28, 21, 9 p., e202200116.Research output: Contribution to journal › Journal article › Research › peer-review
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Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies
Ehsan, M., Du, Y., Scull, N. J., Tikhonova, E., Tarrasch, J., Mortensen, Jonas Sigurd, Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 23 Mar 2016, In: Journal of the American Chemical Society. 138, 11, p. 3789-3796 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length
Cho, K. H., Hariharan, P., Mortensen, Jonas Sigurd, Du, Y., Nielsen, A. K., Byrne, B., Kobilka, B. K., Loland, Claus Juul, Guan, L. & Chae, P. S., 14 Dec 2016, In: ChemBioChem. 17, 24, p. 2334–2339Research output: Contribution to journal › Journal article › Research › peer-review
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Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability
Ehsan, M., Wang, H., Cecchetti, C., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Nygaard, Andreas, Lee, H. J., Ghani, L., Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Chae, P. S., 2021, In: ACS chemical biology. 16, 9, p. 1779–1790 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy
Cho, K. H., Ribeiro, O., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Markham, K., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B., Byrne, B. & Chae, P. S., 23 Dec 2016, In: Chemistry: A European Journal. 22, 52, p. 18833–18839Research output: Contribution to journal › Journal article › Research › peer-review
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New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability
Ehsan, M., Katsube, S., Cecchetti, C., Du, Y., Mortensen, Jonas Sigurd, Wang, H., Nygaard, Andreas, Ghani, L., Loland, Claus Juul, Kobilka, B. K., Byrne, B., Guan, L. & Chae, P. S., 2020, In: ACS chemical biology. 15, 6, p. 1697-1707 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies
Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, Jonas Sigurd, Ribeiro, O., Hu, H., Skiniotis, G., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., Oct 2017, In: Analyst. 142, 20, p. 3889-3898 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization
Bae, H. E., Cecchetti, C., Du, Y., Katsube, S., Mortensen, Jonas Sigurd, Huang, W., Rehan, S., Lee, H. J., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2020, In: Acta Biomaterialia. 112, p. 250-261 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy
Das, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Lee, H. S., Byrne, B., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2018, In: ChemBioChem. 19, 20, p. 2225-2232 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability
Hussain, H., Du, Y., Tikhonova, E., Mortensen, Jonas Sigurd, Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Chemistry - A European Journal. 23, 28, p. 6724-6729 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability
Ehsan, M., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Qu, Q., Ghani, L., Das, M., Grethen, A., Byrne, B., Skiniotis, G., Keller, S., Loland, Claus Juul, Guan, L., Kobilka, B. K. & Chae, P. S., 2019, In: Chemistry: A European Journal. 25, 49, p. 11545-11554Research output: Contribution to journal › Journal article › Research › peer-review
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Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study
Ehsan, M., Kumar, A., Mortensen, Jonas Sigurd, Du, Y., Hariharan, P., Kumar, K. K., Ha, B., Byrne, B., Guan, L., Kobilka, B. K., Loland, Claus Juul & Chae, P. S., 2019, In: Chemistry - An Asian Journal. 14, 11, p. 1926-1931 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Short-Range Distance Measurement by Transition Metal Ion FRET
Mortensen, Jonas Sigurd & Loland, Claus Juul, 2020, Biophysics of membrane proteins. Humana Press, p. 299-311 13 p. (Methods in Molecular Biology, Vol. 2168).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Steroid-based amphiphiles for membrane protein study: The importance of alkyl spacers for protein stability
Ehsan, M., Das, M., Stern, V., Du, Y., Mortensen, Jonas Sigurd, Hariharan, P., Byrne, B., Loland, Claus Juul, Kobilka, B. K., Guan, L. & Chae, P. S., 2018, In: ChemBioChem. 19, 13, p. 1433-1443 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter
Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, K., Mortensen, Jonas Sigurd, Javitch, J. A., Weinstein, H., Loland, Claus Juul & Gether, Ulrik, 30 Oct 2015, In: Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tandem malonate-based glucosides (TMGs) for membrane protein structural studies
Hussain, H., Mortensen, Jonas Sigurd, Du, Y., Santillan, C., Ribeiro, O., Go, J., Hariharan, P., Loland, Claus Juul, Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, In: Scientific Reports. 7, 1, 11 p., 3963.Research output: Contribution to journal › Journal article › Research › peer-review
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Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation
Bae, H. E., Mortensen, Jonas Sigurd, Ribeiro, O., Du, Y., Ehsan, M., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Chae, P. S., 4 Oct 2016, In: Chemical communications (Cambridge, England). 52, 81, p. 12104-12107 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter
Billesbølle, C. B., Mortensen, Jonas Sigurd, Sohail, A., Schmidt, S. G., Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In: Nature Communications. 7, 12 p., 12755.Research output: Contribution to journal › Journal article › Research › peer-review
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Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability
Das, M., Du, Y., Mortensen, Jonas Sigurd, Ramos, M., Ghani, L., Lee, H. J., Bae, H. E., Byrne, B., Guan, L., Loland, Claus Juul, Kobilka, B. K. & Chae, P. S., 2019, In: Organic & Biomolecular Chemistry. 17, 12, p. 3249-3257 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vitamin E-based glycoside amphiphiles for membrane protein structural studies
Ehsan, M., Du, Y., Molist, I., Seven, A. B., Hariharan, P., Mortensen, Jonas Sigurd, Ghani, L., Loland, Claus Juul, Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 2018, In: Organic and Biomolecular Chemistry. 16, 14, p. 2489-2498 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 142011403
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Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
195
downloads
A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
185
downloads
Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region
Research output: Contribution to journal › Journal article › Research › peer-review
Published