Janine Erler
Professor
Erler Group
Ole Maaløes Vej 5
2200 København N.
- Published
Interplay between LOX enzymes and integrins in the tumor microenvironment
Amendola, P. G., Reuten, R. & Erler, Janine, May 2019, In: Cancers. 11, 5, 17 p., 729.Research output: Contribution to journal › Review › Research › peer-review
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Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK
Baker, A., Bird, D., Lang, G., Cox, T. R. & Erler, Janine, 4 Apr 2013, In: Oncogene. 32, 14, p. 1863-8Research output: Contribution to journal › Journal article › Research › peer-review
The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer
Baker, A., Cox, T. R., Bird, D., Lang, G., Murray, G. I., Sun, X., Southall, S. M., Wilson, J. R. & Erler, Janine, 2011, In: National Cancer Institute. Journal (Online). 103, 5, p. 407-24 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis
Baker, A., Bird, D., Welti, J. C., Gourlaouen, M., Lang, G., Murray, G. I., Reynolds, A. R., Cox, T. R. & Erler, Janine, 2013, In: Cancer Research.Research output: Contribution to journal › Journal article › Research › peer-review
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
Barker, H. E., Chang, J., Cox, T. R., Lang, G., Bird, D., Nicolau, M., Evans, H. R., Gartland, A. & Erler, Janine, 1 Mar 2011, In: Cancer Research. 71, 5, p. 1561-1572 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The rationale for targeting the LOX family in cancer
Barker, H. E., Cox, T. R. & Erler, Janine, 19 Jul 2012, In: Nature Reviews. Cancer. 12, 8, p. 540-52 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The potential for LOXL2 as a target for future cancer treatment
Barker, H. E. & Erler, Janine, Jun 2011, In: Future Oncology. 7, 6, p. 707-10 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
Barker, H. E., Chang, J., Cox, T. R., Lang, G., Bird, D., Nicolau, M., Evans, H. R., Gartland, A. & Erler, Janine, 2011, In: Cancer Research. 71, 5, p. 1561-72 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tumor-secreted LOXL2 activates fibroblasts through FAK signaling
Barker, H. E., Bird, D., Lang, G. & Erler, Janine, Nov 2013, In: Molecular Cancer Research. 11, 11, p. 1425-36 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth
Bennewith, K. L., Huang, X., Ham, C. M., Graves, E. E., Erler, Janine, Kambham, N., Feazell, J., Yang, G. P., Koong, A. & Giaccia, A. J., 1 Feb 2009, In: Cancer Research. 69, 3, p. 775-84 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Premetastatic Niches
Bennewith, K. L., Erler, Janine & Giaccia, A. J., 31 Aug 2010, Tumor Microenvironment. John Wiley and Sons, Inc., p. 161-182 22 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Stimulating translational research: several European life science institutions put their heads together
Bentires-Alj, M., Rajan, A., van Harten, W., van Luenen, H. G. A. M., Kubicek, S., Andersen, Jesper Bøje, Saarela, J., Cook, S. J., Van Minnebruggen, G., Roman-Roman, S., Maurer, C., Erler, Janine & Bertero, M. G., 2015, In: Trends in Molecular Medicine. 21, 9, p. 525-527 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Notch-inducing hydrogels reveal a perivascular switch of mesenchymal stem cell fate
Blache, U., Vallmajo-Martin, Q., Horton, E. R., Guerrero, J., Djonov, V., Scherberich, A., Erler, Janine, Martin, I., Snedeker, J. G., Milleret, V. & Ehrbar, M., 2018, In: EMBO Reports. 19, 8, p. 1-14 14 p., e45964.Research output: Contribution to journal › Journal article › Research › peer-review
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Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments
Blache, U., Horton, E. R., Xia, T., Schoof, E. M., Blicher, L. H., Schönenberger, A., Snedeker, J. G., Martin, I., Erler, Janine & Ehrbar, M., 1 Jan 2019, In: Life Science Alliance. 2, 3, 15 p., e201900304.Research output: Contribution to journal › Journal article › Research › peer-review
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1
Brown, L. M., Cowen, R. L., Debray, C., Eustace, A., Erler, Janine, Sheppard, F. C. D., Parker, C. A., Stratford, I. J. & Williams, K. J., Feb 2006, In: Molecular Pharmacology. 69, 2, p. 411-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tipping the balance: New insights into stromal regulation of cancer
Castro, Joana & Erler, Janine, 2022, In: Cancer Cell. 40, 12, p. 1467-1469 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Hypoxia-mediated metastasis
Chang, J. & Erler, Janine, 2014, Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging, and Therapeutic Targets. Springer New York LLC, p. 55-81 27 p. (Advances in Experimental Medicine and Biology, Vol. 772).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling
Chang, J., Nicolau, M., Cox, T. R., Wetterskog, D., Martens, J. W. M., Barker, H. E. & Erler, Janine, 23 Aug 2013, In: Breast cancer research : BCR. 15, 4, p. R67Research output: Contribution to journal › Journal article › Research › peer-review
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Quantification of Lung Metastases from In Vivo Mouse Models
Chang, J. & Erler, Janine, 2016, Advances in Experimental Medicine and Biology: Tumor Microenvironment. Koumenis, C., Coussens, L. M., Giaccia, A. & Hammond, E. (eds.). Springer, Vol. 899. p. 245-51 7 p. (Advances in Experimental Medicine and Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Chang, J., Lucas, M. C., Leonte, L. E., Garcia-Montolio, M., Singh, L. B., Findlay, A. D., Deodhar, M., Foot, J. S., Jarolimek, W., Timpson, P., Erler, Janine & Cox, T. R., 10 Feb 2017, In: OncoTarget. 8, 16, p. 26066-26078 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Friction-limited cell motility in confluent monolayer tissue
Christensen, A., West, A. V., Wullkopf, L., Erler, Janine, Oddershede, L. B. & Mathiesen, Joachim, 25 Jul 2018, In: Physical Biology. 15, 6, 11 p., 066004.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysyl oxidase in colorectal cancer
Cox, T. R. & Erler, Janine, 15 Nov 2013, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 305, 10, p. G659-66Research output: Contribution to journal › Review › Research › peer-review
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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
Cox, T. R., Rumney, R. M. H., Schoof, E. M., Perryman, L., Høye, A. M., Agrawal, A., Bird, D., Latif, N. A., Forrest, H., Evans, H. R., Huggins, I. D., Lang, G., Linding, R., Gartland, A. & Erler, Janine, 27 May 2015, In: Nature.Research output: Contribution to journal › Journal article › Research › peer-review
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LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis
Cox, T. R., Bird, D., Baker, A., Barker, H. E., Ho, M. W., Lang, G. & Erler, Janine, 15 Mar 2013, In: Cancer Research. 73, 6, p. 1721-32 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular pathways: connecting fibrosis and solid tumor metastasis
Cox, T. R. & Erler, Janine, 15 Jul 2014, In: Clinical Cancer Research. 20, 14, p. 3637-43 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism
Cox, T. R., Schoof, E. M., Gartland, A., Erler, Janine & Linding, R., 2015, In: Data in Brief. 5, p. 621-625 5 p.Research output: Contribution to journal › Journal article › Commissioned › peer-review
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Remodelling of the extracellular matrix: Implications for cancer
Cox, T. R. & Erler, Janine, 1 Jun 2013, Cell and Molecular Biology of Breast Cancer. Humana Press, p. 65-90 26 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease
Cox, T. R., Erler, Janine & Rumney, R. M. H., 1 Feb 2018, In: Calcified Tissue International. 102, 2, p. 163-173 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Fibrosis and Cancer: Partners in Crime or Opposing Forces?
Cox, T. R. & Erler, Janine, 2016, In: Trends in Cancer. 2, 6, p. 279-282 4 p.Research output: Contribution to journal › Review › Research › peer-review
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Cox, T. R. & Erler, Janine, 2011, In: Disease Models and Mechanisms. 4, 2, p. 165-78 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis
Cox, T. R., Gartland, A. & Erler, Janine, 15 Jan 2016, In: Cancer Research. 76, 2, p. 188-92 5 p.Research output: Contribution to journal › Review › Research › peer-review
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Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling
Creixell, P., Schoof, E. M., Simpson, C. D., Longden, J., Miller, C. J., Lou, H. J., Perryman, L., Cox, T. R., Zivanovic, N., Palmeri, A., Wesolowska-Andersen, A., Helmer-Citterich, M., Ferkinghoff-Borg, J., Itamochi, H., Bodenmiller, B., Erler, Janine, Turk, B. E. & Linding, R., 16 Sep 2015, In: Cell.Research output: Contribution to journal › Journal article › Research › peer-review
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Navigating cancer network attractors for tumor-specific therapy
Creixell, P., Schoof, E., Erler, Janine & Linding, R., Sep 2012, In: Nature Biotechnology. 30, 9, p. 842-8 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Identification of hypoxia-regulated proteins using MALDI-Mass Spectrometry Imaging combined with quantitative proteomics
Djidja, M., Chang, J., Hadjiprocopis, A., Schmich, F., Sinclair, J., Mršnik, M., Schoof, E., Barker, H. E., Linding, R., Jorgensen, C. & Erler, Janine, 7 Apr 2014, In: Journal of Proteome Research.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of acute exercise training on tumor outcomes in men with localized prostate cancer: A randomized controlled trial
Djurhuus, S. S., Schauer, T., Simonsen, C., Toft, Birgitte Grønkær, Jensen, A. R. D., Erler, Janine, Røder, Andreas, Hojman, P., Brasso, K. & Christensen, J. F., 2022, In: Physiological Reports. 10, 19, e15408.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of tumor progression and metastasis by bone marrow-derived microenvironments
El Rayes, T., Gao, D., Altorki, N. K., Cox, T. R., Erler, Janine & Mittal, V., 2017, Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications. Akslen, L. A. & Watnick, R. S. (eds.). Springer, p. 303-328 26 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Potential for quantitative microelastography using a multi-channel optical coherence method
Elyas, E., Erler, Janine, Robinson, S. P., Cox, T., Woods, D., Clowes, P. & Bamber, J. C., 1 Dec 2012, 2012 IEEE International Ultrasonics Symposium, IUS 2012. 6562412. (IEEE International Ultrasonics Symposium, IUS).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
Elyas, E., Papaevangelou, E., Alles, E. J., Erler, Janine, Cox, T. R., Robinson, S. P. & Bamber, J. C., 2017, In: Scientific Reports. 7, 9 p., 165.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight
Elyas, E., Grimwood, A., Erler, Janine, Robinson, S. P., Cox, T. R., Woods, D., Clowes, P., De Luca, R., Marinozzi, F., Fromageau, J. & Bamber, J. C., 2017, In: PLOS ONE. 12, 1, 18 p., e0169664.Research output: Contribution to journal › Journal article › Research › peer-review
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Network medicine strikes a blow against breast cancer
Erler, Janine & Linding, R., 11 May 2012, In: Cell. 149, 4, p. 731-3 3 p.Research output: Contribution to journal › Review › Research › peer-review
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Erler, Janine, Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q. & Giaccia, A. J., 2009, In: Cancer Cell. 15, 1, p. 35-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cancer: Disabling defences in the brain
Erler, Janine, 3 Apr 2014, In: Nature. 508, 7494, p. 46-7 2 p.Research output: Contribution to journal › Review › Research › peer-review
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, Janine, Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q., Chi, J. A., Jeffrey, S. S. & Giaccia, A. J., 27 Apr 2006, In: Nature. 440, 7088, p. 1222-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Three-dimensional context regulation of metastasis
Erler, Janine & Weaver, V. M., 2009, In: Clinical and Experimental Metastasis. 26, 1, p. 35-49 15 p.Research output: Contribution to journal › Journal article › Commissioned › peer-review
Network-based drugs and biomarkers
Erler, Janine & Linding, R., Jan 2010, In: Journal of Pathology. 220, 2, p. 290-6 7 p.Research output: Contribution to journal › Journal article › Commissioned › peer-review
Lysyl oxidase mediates hypoxic control of metastasis
Erler, Janine & Giaccia, A. J., 1 Nov 2006, In: Cancer Research. 66, 21, p. 10238-41 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
Erler, Janine, Cawthorne, C. J., Williams, K. J., Koritzinsky, M., Wouters, B. G., Wilson, C., Miller, C., Demonacos, C., Stratford, I. J. & Dive, C., Apr 2004, In: Molecular and Cellular Biology. 24, 7, p. 2875-89 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interdisciplinary research: Bold alliances aid translational work
Erler, Janine, 22 Jan 2015, In: Nature. 517, 7535, p. 438Research output: Contribution to journal › Comment/debate › Research › peer-review
Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity
Esposti, M. D., Erler, Janine, Hickman, J. A. & Dive, C., Nov 2001, In: Molecular and Cellular Biology. 21, 21, p. 7268-76 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example
on behalf of the Board of the Metastasis Research Society, O. B. O. T. B. O. T. M. R. S., 1 Dec 2017, In: Clinical and Experimental Metastasis. 34, 8, p. 443-447 5 p.Research output: Contribution to journal › Editorial › Research › peer-review
ID: 35362336
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Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Research output: Contribution to journal › Journal article › Research › peer-review
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194
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Friction-limited cell motility in confluent monolayer tissue
Research output: Contribution to journal › Journal article › Research › peer-review
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167
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Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments
Research output: Contribution to journal › Journal article › Research › peer-review
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