Janine Erler

Janine Erler

Professor


  1. Published

    Interplay between LOX enzymes and integrins in the tumor microenvironment

    Amendola, P. G., Reuten, R. & Erler, Janine, May 2019, In: Cancers. 11, 5, 17 p., 729.

    Research output: Contribution to journalReviewResearchpeer-review

  2. Published

    Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

    Baker, A., Bird, D., Lang, G., Cox, T. R. & Erler, Janine, 4 Apr 2013, In: Oncogene. 32, 14, p. 1863-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer

    Baker, A., Cox, T. R., Bird, D., Lang, G., Murray, G. I., Sun, X., Southall, S. M., Wilson, J. R. & Erler, Janine, 2011, In: National Cancer Institute. Journal (Online). 103, 5, p. 407-24 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis

    Baker, A., Bird, D., Welti, J. C., Gourlaouen, M., Lang, G., Murray, G. I., Reynolds, A. R., Cox, T. R. & Erler, Janine, 2013, In: Cancer Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution

    Barker, H. E., Chang, J., Cox, T. R., Lang, G., Bird, D., Nicolau, M., Evans, H. R., Gartland, A. & Erler, Janine, 1 Mar 2011, In: Cancer Research. 71, 5, p. 1561-1572 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The rationale for targeting the LOX family in cancer

    Barker, H. E., Cox, T. R. & Erler, Janine, 19 Jul 2012, In: Nature Reviews. Cancer. 12, 8, p. 540-52 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The potential for LOXL2 as a target for future cancer treatment

    Barker, H. E. & Erler, Janine, Jun 2011, In: Future Oncology. 7, 6, p. 707-10 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. LOXL2-mediated matrix remodeling in metastasis and mammary gland involution

    Barker, H. E., Chang, J., Cox, T. R., Lang, G., Bird, D., Nicolau, M., Evans, H. R., Gartland, A. & Erler, Janine, 2011, In: Cancer Research. 71, 5, p. 1561-72 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Tumor-secreted LOXL2 activates fibroblasts through FAK signaling

    Barker, H. E., Bird, D., Lang, G. & Erler, Janine, Nov 2013, In: Molecular Cancer Research. 11, 11, p. 1425-36 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth

    Bennewith, K. L., Huang, X., Ham, C. M., Graves, E. E., Erler, Janine, Kambham, N., Feazell, J., Yang, G. P., Koong, A. & Giaccia, A. J., 1 Feb 2009, In: Cancer Research. 69, 3, p. 775-84 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Premetastatic Niches

    Bennewith, K. L., Erler, Janine & Giaccia, A. J., 31 Aug 2010, Tumor Microenvironment. John Wiley and Sons, Inc., p. 161-182 22 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  12. Published

    Stimulating translational research: several European life science institutions put their heads together

    Bentires-Alj, M., Rajan, A., van Harten, W., van Luenen, H. G. A. M., Kubicek, S., Andersen, Jesper Bøje, Saarela, J., Cook, S. J., Van Minnebruggen, G., Roman-Roman, S., Maurer, C., Erler, Janine & Bertero, M. G., 2015, In: Trends in Molecular Medicine. 21, 9, p. 525-527 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Notch-inducing hydrogels reveal a perivascular switch of mesenchymal stem cell fate

    Blache, U., Vallmajo-Martin, Q., Horton, E. R., Guerrero, J., Djonov, V., Scherberich, A., Erler, Janine, Martin, I., Snedeker, J. G., Milleret, V. & Ehrbar, M., 2018, In: EMBO Reports. 19, 8, p. 1-14 14 p., e45964.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments

    Blache, U., Horton, E. R., Xia, T., Schoof, E. M., Blicher, L. H., Schönenberger, A., Snedeker, J. G., Martin, I., Erler, Janine & Ehrbar, M., 1 Jan 2019, In: Life Science Alliance. 2, 3, 15 p., e201900304.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1

    Brown, L. M., Cowen, R. L., Debray, C., Eustace, A., Erler, Janine, Sheppard, F. C. D., Parker, C. A., Stratford, I. J. & Williams, K. J., Feb 2006, In: Molecular Pharmacology. 69, 2, p. 411-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Tipping the balance: New insights into stromal regulation of cancer

    Castro, Joana & Erler, Janine, 2022, In: Cancer Cell. 40, 12, p. 1467-1469 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  17. Published

    Hypoxia-mediated metastasis

    Chang, J. & Erler, Janine, 2014, Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging, and Therapeutic Targets. Springer New York LLC, p. 55-81 27 p. (Advances in Experimental Medicine and Biology, Vol. 772).

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  18. Published

    LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling

    Chang, J., Nicolau, M., Cox, T. R., Wetterskog, D., Martens, J. W. M., Barker, H. E. & Erler, Janine, 23 Aug 2013, In: Breast cancer research : BCR. 15, 4, p. R67

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Quantification of Lung Metastases from In Vivo Mouse Models

    Chang, J. & Erler, Janine, 2016, Advances in Experimental Medicine and Biology: Tumor Microenvironment. Koumenis, C., Coussens, L. M., Giaccia, A. & Hammond, E. (eds.). Springer, Vol. 899. p. 245-51 7 p. (Advances in Experimental Medicine and Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  20. Published

    Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

    Chang, J., Lucas, M. C., Leonte, L. E., Garcia-Montolio, M., Singh, L. B., Findlay, A. D., Deodhar, M., Foot, J. S., Jarolimek, W., Timpson, P., Erler, Janine & Cox, T. R., 10 Feb 2017, In: OncoTarget. 8, 16, p. 26066-26078 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Friction-limited cell motility in confluent monolayer tissue

    Christensen, A., West, A. V., Wullkopf, L., Erler, Janine, Oddershede, L. B. & Mathiesen, Joachim, 25 Jul 2018, In: Physical Biology. 15, 6, 11 p., 066004.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Lysyl oxidase in colorectal cancer

    Cox, T. R. & Erler, Janine, 15 Nov 2013, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 305, 10, p. G659-66

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

    Cox, T. R., Rumney, R. M. H., Schoof, E. M., Perryman, L., Høye, A. M., Agrawal, A., Bird, D., Latif, N. A., Forrest, H., Evans, H. R., Huggins, I. D., Lang, G., Linding, R., Gartland, A. & Erler, Janine, 27 May 2015, In: Nature.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis

    Cox, T. R., Bird, D., Baker, A., Barker, H. E., Ho, M. W., Lang, G. & Erler, Janine, 15 Mar 2013, In: Cancer Research. 73, 6, p. 1721-32 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Molecular pathways: connecting fibrosis and solid tumor metastasis

    Cox, T. R. & Erler, Janine, 15 Jul 2014, In: Clinical Cancer Research. 20, 14, p. 3637-43 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism

    Cox, T. R., Schoof, E. M., Gartland, A., Erler, Janine & Linding, R., 2015, In: Data in Brief. 5, p. 621-625 5 p.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  27. Published

    Remodelling of the extracellular matrix: Implications for cancer

    Cox, T. R. & Erler, Janine, 1 Jun 2013, Cell and Molecular Biology of Breast Cancer. Humana Press, p. 65-90 26 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  28. Published

    Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease

    Cox, T. R., Erler, Janine & Rumney, R. M. H., 1 Feb 2018, In: Calcified Tissue International. 102, 2, p. 163-173 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Fibrosis and Cancer: Partners in Crime or Opposing Forces?

    Cox, T. R. & Erler, Janine, 2016, In: Trends in Cancer. 2, 6, p. 279-282 4 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

    Cox, T. R. & Erler, Janine, 2011, In: Disease Models and Mechanisms. 4, 2, p. 165-78 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis

    Cox, T. R., Gartland, A. & Erler, Janine, 15 Jan 2016, In: Cancer Research. 76, 2, p. 188-92 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling

    Creixell, P., Schoof, E. M., Simpson, C. D., Longden, J., Miller, C. J., Lou, H. J., Perryman, L., Cox, T. R., Zivanovic, N., Palmeri, A., Wesolowska-Andersen, A., Helmer-Citterich, M., Ferkinghoff-Borg, J., Itamochi, H., Bodenmiller, B., Erler, Janine, Turk, B. E. & Linding, R., 16 Sep 2015, In: Cell.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Navigating cancer network attractors for tumor-specific therapy

    Creixell, P., Schoof, E., Erler, Janine & Linding, R., Sep 2012, In: Nature Biotechnology. 30, 9, p. 842-8 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    Identification of hypoxia-regulated proteins using MALDI-Mass Spectrometry Imaging combined with quantitative proteomics

    Djidja, M., Chang, J., Hadjiprocopis, A., Schmich, F., Sinclair, J., Mršnik, M., Schoof, E., Barker, H. E., Linding, R., Jorgensen, C. & Erler, Janine, 7 Apr 2014, In: Journal of Proteome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Effects of acute exercise training on tumor outcomes in men with localized prostate cancer: A randomized controlled trial

    Djurhuus, S. S., Schauer, T., Simonsen, C., Toft, Birgitte Grønkær, Jensen, A. R. D., Erler, Janine, Røder, Andreas, Hojman, P., Brasso, K. & Christensen, J. F., 2022, In: Physiological Reports. 10, 19, e15408.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Regulation of tumor progression and metastasis by bone marrow-derived microenvironments

    El Rayes, T., Gao, D., Altorki, N. K., Cox, T. R., Erler, Janine & Mittal, V., 2017, Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications. Akslen, L. A. & Watnick, R. S. (eds.). Springer, p. 303-328 26 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  37. Published

    Potential for quantitative microelastography using a multi-channel optical coherence method

    Elyas, E., Erler, Janine, Robinson, S. P., Cox, T., Woods, D., Clowes, P. & Bamber, J. C., 1 Dec 2012, 2012 IEEE International Ultrasonics Symposium, IUS 2012. 6562412. (IEEE International Ultrasonics Symposium, IUS).

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  38. Published

    Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model

    Elyas, E., Papaevangelou, E., Alles, E. J., Erler, Janine, Cox, T. R., Robinson, S. P. & Bamber, J. C., 2017, In: Scientific Reports. 7, 9 p., 165.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight

    Elyas, E., Grimwood, A., Erler, Janine, Robinson, S. P., Cox, T. R., Woods, D., Clowes, P., De Luca, R., Marinozzi, F., Fromageau, J. & Bamber, J. C., 2017, In: PLOS ONE. 12, 1, 18 p., e0169664.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Network medicine strikes a blow against breast cancer

    Erler, Janine & Linding, R., 11 May 2012, In: Cell. 149, 4, p. 731-3 3 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

    Erler, Janine, Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q. & Giaccia, A. J., 2009, In: Cancer Cell. 15, 1, p. 35-44 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Cancer: Disabling defences in the brain

    Erler, Janine, 3 Apr 2014, In: Nature. 508, 7494, p. 46-7 2 p.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Lysyl oxidase is essential for hypoxia-induced metastasis

    Erler, Janine, Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q., Chi, J. A., Jeffrey, S. S. & Giaccia, A. J., 27 Apr 2006, In: Nature. 440, 7088, p. 1222-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Three-dimensional context regulation of metastasis

    Erler, Janine & Weaver, V. M., 2009, In: Clinical and Experimental Metastasis. 26, 1, p. 35-49 15 p.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  45. Network-based drugs and biomarkers

    Erler, Janine & Linding, R., Jan 2010, In: Journal of Pathology. 220, 2, p. 290-6 7 p.

    Research output: Contribution to journalJournal articleCommissionedpeer-review

  46. Lysyl oxidase mediates hypoxic control of metastasis

    Erler, Janine & Giaccia, A. J., 1 Nov 2006, In: Cancer Research. 66, 21, p. 10238-41 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

    Erler, Janine, Cawthorne, C. J., Williams, K. J., Koritzinsky, M., Wouters, B. G., Wilson, C., Miller, C., Demonacos, C., Stratford, I. J. & Dive, C., Apr 2004, In: Molecular and Cellular Biology. 24, 7, p. 2875-89 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Interdisciplinary research: Bold alliances aid translational work

    Erler, Janine, 22 Jan 2015, In: Nature. 517, 7535, p. 438

    Research output: Contribution to journalComment/debateResearchpeer-review

  49. Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity

    Esposti, M. D., Erler, Janine, Hickman, J. A. & Dive, C., Nov 2001, In: Molecular and Cellular Biology. 21, 21, p. 7268-76 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example

    on behalf of the Board of the Metastasis Research Society, O. B. O. T. B. O. T. M. R. S., 1 Dec 2017, In: Clinical and Experimental Metastasis. 34, 8, p. 443-447 5 p.

    Research output: Contribution to journalEditorialResearchpeer-review

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