Henrik Nyhus Kløverpris

Henrik Nyhus Kløverpris

Associate Professor

ORCID: 0000-0002-2165-3313

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  1. Published

    A Randomised, Placebo-Controlled, First-In-Human Study of a Novel Clade C Therapeutic Peptide Vaccine Administered Ex Vivo to Autologous White Blood Cells in HIV Infected Individuals

    Jackson, Andrew D., Kløverpris, Henrik Nyhus, Boffito, M., Handley, A., Atkins, M., Hayes, P., Gilmour, J., Riddel, L., Chen, F., Bailey-Tippets, M., Walker, B., Ackland, J., Sullivan, M. & Goulder, P., 2013, In: PLoS ONE.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

    Kløverpris, Henrik Nyhus, Cole, D. K., Fuller, A., Carlson, J., Beck, K., Schauenburg, A. J., Rizkallah, P. J., Buus, Søren, Sewell, A. K. & Goulder, P., 20 Feb 2015, In: Retrovirology. 12, p. 1-11 11 p., 20.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. A simple, robust flow cytometry-based whole blood assay for investigating sex differential interferon alpha production by plasmacytoid dendritic cells

    Sampson, O., Lim, N., White, J., Vieira, V., Kløverpris, Henrik Nyhus, Adland, E., Conlon, C., Skelly, D., Jones, L., Stafford, L., Jamsen, A., Barnes, E., Dunachie, S., Frater, J., Klenerman, P., Altfeld, M. & Goulder, P., 2022, In: Journal of Immunological Methods. 504, 113263.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    CD8+ TCR Bias and Immunodominance in HIV-1 Infection

    Kløverpris, Henrik Nyhus, McGregor, R., McLaren, J. E., Ladell, K., Harndahl, M., Buus, Anette Stryhn, Carlson, J. M., Koofhethile, C., Gerritsen, B., Kesmir, C., Chen, F., Riddell, L., Luzzi, G., Leslie, A., Walker, B. D., Ndung'u, T., Buus, Søren, Price, D. A. & Goulder, P. J., 1 Jun 2015, In: Journal of Immunology. 194, 11, p. 5329-5345 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    CD8αα expression marks terminally differentiated human CD8+ T cells expanded in chronic viral infection

    Walker, L. J., Marrinan, E., Muenchhoff, M., Ferguson, J., Kløverpris, Henrik Nyhus, Cheroutre, H., Barnes, E., Goulder, P. & Klenerman, P., 2013, In: Frontiers in Immunology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

    Attaf, M., Roider, J., Malik, A., Rius Rafael, C., Dolton, G., Predergast, A. J., Leslie, A., Ndung'u, T., Kløverpris, Henrik Nyhus, Sewell, A. K. & Goulder, P. J., 2020, In: Frontiers in Immunology. 11, 1587.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children

    Muenchhoff, M., Adland, E., Roider, J., Kløverpris, Henrik Nyhus, Leslie, A., Boehm, S., Keppler, O. T., Ndung'u, T. & Goulder, P. J. R., 2019, In: The Journal of Infectious Diseases. 219, 9, p. 1407-1417 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

    Matthews, P. C., Koyanagi, M., Kløverpris, H. N., Harndahl, M., Buus, A. S., Akahoshi, T., Gatanaga, H., Oka, S., Juarez Molina, C., Valenzuela Ponce, H., Avila Rios, S., Cole, D., Carlson, J., Payne, R. P., Ogwu, A., Bere, A., Ndung'u, T., Gounder, K., Chen, F., Riddell, L. & 11 others, Luzzi, G., Shapiro, R., Brander, C., Walker, B., Sewell, A. K., Reyes Teran, G., Heckerman, D., Hunter, E., Buus, Søren, Takiguchi, M. & Goulder, P. J. R., Dec 2012, In: Journal of Virology. 86, 23, p. 12643-12654 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Differential escape patterns within the dominant HLA-B*57:03-restricted HIV gag epitope reflect distinct clade-specific functional constraints

    Payne, R. P., Branch, S., Kløverpris, H., Matthews, P. C., Koofhethile, C. K., Strong, T., Adland, E., Leitman, E., Frater, J., Ndung'u, T., Hunter, E., Haubrich, R., Mothe, B., Edwards, A., Riddell, L., Chen, F., Harrigan, P. R., Brumme, Z. L., Mallal, S., John, M. & 9 others, Jooste, J. P., Shapiro, R., Deeks, S. G., Walker, B. D., Brander, C., Landis, C., Carlson, J. M., Prado, J. G. & Gouldera, P. J. R., 2014, In: Journal of Virology. 88, 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Dimethyl sulfoxide (DMSO) exposure to human peripheral blood mononuclear cells (PBMCs) abolish T cell responses only in high concentrations and following coincubation for more than two hours

    Kløverpris, Henrik Nyhus, Fomsgaard, A., Handley, A., Ackland, J., Sullivan, M. & Goulder, P., Apr 2010, In: Journal of Immunological Methods. 356, 1-2, p. 70-78 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

    Muenchhoff, M., Chung, A. W., Roider, J., Dugast, A. S., Richardson, S., Kløverpris, Henrik Nyhus, Leslie, A., Ndung’u, T., Moore, P., Alter, G. & Gouldera, P. J. R., 2020, In: mSphere. 5, 6, p. 1-16 e00880-20.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T Cells

    Kløverpris, Henrik Nyhus, Payne, R. P., Sacha, J. B., Rasaiyaah, J. T., Chen, F., Takiguchi, M., Yang, O. O., Towers, G. J., Goulder, P. & Prado, J. G., 2013, In: Journal of Virology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B*2705-restricted CD8+ T cells

    Payne, R. P., Kløverpris, Henrik Nyhus, Sacha, J. B., Brumme, Z., Brumme, C., Buus, Søren, Sims, S., Hickling, S., Riddell, L., Chen, F., Luzzi, G., Edwards, A., Phillips, R., Prado, J. G. & Goulder, P. J. R., 2010, In: Journal of Virology. 84, 20, p. 10543-10557

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity

    Riou, C., Keeton, R., Moyo-Gwete, T., Hermanus, T., Kgagudi, P., Baguma, R., Valley-Omar, Z., Smith, M., Tegally, H., Doolabh, D., Iranzadeh, A., Tyers, L., Mutavhatsindi, H., Tincho, M. B., Benede, N., Marais, G., Chinhoyi, L. R., Mennen, M., Skelem, S., du Bruyn, E. & 31 others, Stek, C., de Oliveira, T., Williamson, C., Moore, P. L., Wilkinson, R. J., Ntusi, N. A. B., Burgers, W. A., Abrahams, F., Ayres, F., du Toit, E., Goliath, R. T., Hanekom, W., Hardie, D., Hsiao, N. Y., Kløverpris, Henrik Nyhus, Korsman, S., Lakay, F., Lambson, B., Leslie, A., Makhado, Z., Maseko, M., Mhlanga, D., Naidoo, M., Ndhlovu, Z., Ngomti, A., Oosthuysen, B., Ruzive, S., Sigal, A., Smith, T., van der Westhuizen, D. & South African Cellular Immunity Network, S. A. C. I. N., 2022, In: Science Translational Medicine. 14, 631, eabj6824.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

    Cele, S., Network for Genomic Surveillance in South Africa, N. F. G. S. I. S. A. & COMMIT-KZN Team, C. T., 2021, In: Nature. 593, 7857, p. 142-146 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

    Ardain, A., Domingo-Gonzalez, R., Das, S., Kazer, S. W., Howard, N. C., Singh, A., Ahmed, M., Nhamoyebonde, S., Rangel-Moreno, J., Ogongo, P., Lu, L., Ramsuran, D., de la Luz Garcia-Hernandez, M., K. Ulland, T., Darby, M., Park, E., Karim, F., Melocchi, L., Madansein, R., Dullabh, K. J. & 16 others, Dunlap, M., Marin-Agudelo, N., Ebihara, T., Ndung’u, T., Kaushal, D., Pym, A. S., Kolls, J. K., Steyn, A., Zúñiga, J., Horsnell, W., Yokoyama, W. M., Shalek, A. K., Kløverpris, Henrik Nyhus, Colonna, M., Leslie, A. & Khader, S. A., 2019, In: Nature. 570, 7762, p. 528-532

    Research output: Contribution to journal › Letter › Research › peer-review

  17. Published

    HIV control through a single nucleotide on the HLA-B locus

    Kløverpris, Henrik Nyhus, Harndahl, M., Leslie, A. J., Carlson, J. M., Ismail, N., van der Stok, M., Huang, K. G., Chen, F., Riddell, L., Steyn, D., Goedhals, D., van Vuuren, C., Frater, J., Walker, B. D., Carrington, M., Ndung'u, T., Buus, Søren & Goulder, P., Nov 2012, In: Journal of Virology. 86, 21, p. 11493-11500 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

    Fardoos, R., Asowata, O. E., Herbert, N., Nyquist, S. K., Zungu, Y., Singh, A., Ngoepe, A., Mbano, I. M., Mthabela, N., Ramjit, D., Karim, F., Kuhn, W., Madela, F. G., Manzini, V. T., Anderson, F., Berger, B., Pers, Tune H, Shalek, A. K., Leslie, A. & Kløverpris, Henrik Nyhus, 2021, In: JCI insight. 6, 16, e148920.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway

    Krause, R., Snyman, J., Shi-Hsia, H., Muema, D., Karim, F., Ganga, Y., Ngoepe, A., Zungu, Y., Gazy, I., Bernstein, M., Khan, K., Mazibuko, M., Mthabela, N., Ramjit, D., Limbo, O., Jardine, J., Sok, D., Wilson, I. A., Hanekom, W., Sigal, A. & 4 others, Kløverpris, Henrik Nyhus, Ndung'u, T., Leslie, A. & COMMIT-KZN Team, C. T., 2022, In: eLife. 11, e79924.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

    Fardoos, R., Nyquist, S. K., Asowata, O. E., Kazer, S. W., Singh, A., Ngoepe, A., Giandhari, J., Mthabela, N., Ramjit, D., Singh, S., Karim, F., Buus, S., Anderson, F., Porterfield, J. Z., Sibiya, A. L., Bipath, R., Moodley, K., Kuhn, W., Berger, B., Nguyen, S. & 6 others, de Oliveira, T., Ndung’u, T., Goulder, P., Shalek, A. K., Leslie, A. & Kløverpris, Henrik Nyhus, 2022, In: Frontiers in Immunology. 13, 912038.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave

    COMMIT-KZN Team, C. T., 2021, In: eLife. 10, e67397.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    HIV subtype influences HLA-B*07:02-associated HIV disease outcome

    Kløverpris, Henrik Nyhus, Adland, E., Koyanagi, M., Buus, Anette Stryhn, Harndahl, M., Matthews, P. C., Shapiro, R., Walker, B. D., Ndung'u, T., Brander, C., Takiguchi, M., Buus, Søren & Goulder, P., May 2014, In: AIDS Research and Human Retroviruses. 30, 5, p. 468-75 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective

    Kløverpris, Henrik Nyhus, Buus, Anette Stryhn, Harndahl, M., Carlson, J. M., Leslie, A. J., Chen, F., Riddell, L., Mulenga, J., Walker, B. D., Ndung'u, T., Buus, Søren & Goulder, P., 17 Jul 2013, In: AIDS (London, England). 27, 11, p. 1717-23 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control

    Kløverpris, Henrik Nyhus, Buus, Anette Stryhn, van der Stok, M., Harndahl, M., Payne, R. P., Matthews, P. C., Chen, F., Riddell, L., Walker, B. D., Ndung'u, T., Buus, Søren & Goulder, P., 2012, In: Journal of Virology. 86, 2, p. 919-29 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01

    Kløverpris, Henrik Nyhus, Stryhn, A., Harndahl, M., Payne, R., Towers, G. J., Chen, F., Riddell, L., Walker, B. D., Ndung'u, T., Leslie, A., Buus, Søren & Goulder, P., 2013, In: Journal of Virology.

    Research output: Contribution to journal › Journal article › Research › peer-review

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