Anne Tybjærg-Hansen
Clinical Professor
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Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Dewey, F. E., Gusarova, V., Dunbar, R. L., O'Dushlaine, C. T., Schurmann, C., Gottesman, O., McCarthy, S., Van Hout, C. V., Bruse, S., Dansky, H. M., Leader, J. B., Murray, M. F., Ritchie, M. D., Kirchner, H. L., Habegger, L., Lopez, A., Penn, J., Zhao, A., Shao, W., Stahl, N. & 37 others, , Jul 2017, In: New England Journal of Medicine. 377, 3, p. 211-221Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variation in Liver X Receptor Alpha and Risk of Ischemic Vascular Disease in the General Population
Stender, Stefan, Frikke-Schmidt, Ruth, Sethi, A. A., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2010, In: Atherosclerosis. Supplement. 11, 2, p. 8-9 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Genetic Variation in GSTP1, Lung Function, Risk of Lung Cancer, and Mortality
Nørskov, M. S., Dahl, Morten & Tybjærg-Hansen, Anne, Nov 2017, In: Journal of Thoracic Oncology. 12, 11, p. 1664-1672 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variation in ABCG1 and Risk of Myocardial Infarction and Ischemic Heart Disease
Schou, J., Frikke-Schmidt, R., Kardassis, D., Thymiakou, E., Nordestgaard, Børge, Jensen, G., Grande, P. & Tybjærg-Hansen, Anne, 2012, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 32, p. 506-15 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variation in NPC1L1 and Risk of Gallstone Disease
Lauridsen, B. K., Stender, S. & Tybjærg-Hansen, Anne, 1 Sep 2015, In: Journal of the American College of Cardiology. 66, 9, p. 1086 1 p.Research output: Contribution to journal › Letter › Research › peer-review
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Genetic Variation at PPP1R3B Increases Hepatic CT Attenuation and Interacts With Prandial Status on Plasma Glucose
Seidelin, A., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Stender, S., 2020, In: Journal of Clinical Endrocrinology and Metabolism. 105, 6, p. 1963–1972Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variants Associated With Increased Plasma Levels of Triglycerides, via Effects on the Lipoprotein Lipase Pathway, Increase Risk of Acute Pancreatitis
Hansen, S. E. J., Madsen, C. M., Varbo, A., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2021, In: Clinical Gastroenterology and Hepatology. 19, 8, p. 1652-1660.e6Research output: Contribution to journal › Journal article › Research › peer-review
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GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm
Bottolo, L., Chadeau-Hyam, M., Hastie, D. I., Zeller, T., Liquet, B., Newcombe, P., Yengo, L., Wild, P. S., Schillert, A., Ziegler, A., Nielsen, S. F., Butterworth, A. S., Ho, W. K., Castagné, R., Munzel, T., Tregouet, D., Falchi, M., Cambien, F., Nordestgaard, B., Fumeron, F. & 7 others, , 2013, In: P L o S Genetics. 9, 8, p. 1-17 17 p., e1003657.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease
Frikke-Schmidt, Ruth, Nordestgaard, Børge, Grande, P., Tybjærg-Hansen, Anne & Schnohr, P., 2008, In: Journal of the American College of Cardiology. 52, 5, p. 369-377 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies
Joshi, A. D., Andersson, C., Buch, S., Stender, S., Noordam, R., Weng, L-C., Weeke, P. E., Auer, P. L., Boehm, B., Chen, C., Choi, H., Curhan, G., Denny, J. C., De Vivo, I., Eicher, J. D., Ellinghaus, D., Folsom, A. R., Fuchs, C., Gala, M., Haessler, J. & 35 others, , Aug 2016, In: Gastroenterology. 151, 2, 351 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fifteen-year follow-up of pulmonary function in individuals heterozygous for the cystic fibrosis phenylalanine-508 deletion
Dahl, M., Nordestgaard, Børge, Lange, Peter & Tybjærg-Hansen, Anne, May 2001, In: Journal of Allergy and Clinical Immunology. 107, 5, p. 818-23 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
Howson, J. M. M., Zhao, W., Barnes, D. R., Ho, W. K., Young, R., Paul, D. S., Waite, L., Freitag, D. F., Fauman, E. B., Salfati, E. L., Sun, B. B., Eicher, J. D., Johnson, A. D., Sheu, W. H-H., Nielsen, S. F., Lin, W-Y., Surendran, P., Malarstig, A., Wilk, J. B., Tybjærg-Hansen, A. & 36 others, , 2017, In: Nature Genetics. 49, p. 1113-1119Research output: Contribution to journal › Letter › Research › peer-review
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Fatalt forløb ved in vitro-fertilisation
Sørensen, Martin Kryspin, Møller-Sørensen, H., Svane, C., Jensen, C. H., Lange, Kai & Tybjærg-Hansen, Anne, 17 May 2010, In: Ugeskrift for Laeger. 172, 20, p. 1537-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication
Benn, M., Watts, G. F., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 3956-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease Consensus Statement of the European Atherosclerosis Society
Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., Wiegman, A., Santos, R. D., Watts, G. F., Parhofer, K. G., Hovingh, G. K., Kovanen, P. T., Boileau, C., Averna, M., Borén, J., Bruckert, E. & 9 others, , 2013, In: European Heart Journal. 34, 45, p. 3478-3490Research output: Contribution to journal › Journal article › Research › peer-review
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Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment
Wiegman, A., Gidding, S. S., Watts, G. F., Chapman, M. J., Ginsberg, H. N., Cuchel, M., Ose, L., Averna, M., Boileau, C., Borén, J., Bruckert, E., Catapano, A. L., Defesche, J. C., Descamps, O. S., Hegele, R. A., Hovingh, G. K., Humphries, S. E., Kovanen, P. T., Kuivenhoven, J. A., Masana, L. & 13 others, , 21 Sep 2015, In: European Heart Journal. 36, 36, p. 2425-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Factor V leiden homozygosity, dyspnea, and reduced pulmonary function.
Juul, K., Tybjærg-Hansen, A., Lange, P., Vestbo, J., Nordestgaard, B., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2005, In: Archives of Internal Medicine.Research output: Contribution to journal › Journal article › Research › peer-review
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Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study
Kamstrup, P. R., Benn, M., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2008, In: Circulation. 117, 2, p. 176-84 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extreme lipoprotein(a) levels and improved cardiovascular risk prediction
Kamstrup, P. R., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 19 Mar 2013, In: Journal of the American College of Cardiology. 61, 11, p. 1146-56 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extreme concentrations of endogenous sex hormones, ischemic heart disease, and death in women
Benn, Marianne, Voss, S. S., Holmegard, H. N., Jensen, G. B., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2 Feb 2015, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 2, p. 471-477 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extreme Bilirubin Levels as a Causal Risk Factor for Symptomatic Gallstone Disease
Stender, Stefan, Frikke-Schmidt, Ruth, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2013, In: Annals of Internal Medicine. 173, 13, p. 1222-1228 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study
Lawlor, D. A., Nordestgaard, Børge, Benn, Marianne, Zuccolo, L., Tybjærg-Hansen, Anne & Davey Smith, G., 14 Mar 2013, In: European Heart Journal (Online).Research output: Contribution to journal › Journal article › Research › peer-review
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Exome-wide association study of plasma lipids in >300,000 individuals
Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 208 others, , 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1758-1766 9 p.Research output: Contribution to journal › Letter › Research › peer-review
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Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
Kozlitina, J., Smagris, E., Stender, Stefan, Nordestgaard, Børge, Zhou, H. H., Tybjærg-Hansen, Anne, Vogt, T. F., Hobbs, H. H. & Cohen, J. C., Apr 2014, In: Nature Genetics. 46, 4, p. 352-356 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
Do, R., Stitziel, N. O., Won, H-H., Jørgensen, A. B., Duga, S., Angelica Merlini, P., Kiezun, A., Farrall, M., Goel, A., Zuk, O., Guella, I., Asselta, R., Lange, L. A., Peloso, G. M., Auer, P. L., Girelli, D., Martinelli, N., Farlow, D. N., DePristo, M. A., Roberts, R. & 31 others, , 5 Feb 2015, In: Nature. 518, 7537, p. 102-6, 4 unpag. pages 9 p.Research output: Contribution to journal › Letter › Research › peer-review
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European Lipoprotein Club: report of the 31st ELC Annual Conference, Tutzing, 8-11 September 2008
Bernini, F., Freeman, D., Groen, A., Heeren, J., Kalopissis, A., Kronenberg, F., Lindstedt, K., Parini, P., Schuster, G., Tybjærg-Hansen, Anne, Dij, K. W. V. & Eckardstein, A. V., 2009, In: Atherosclerosis. 205, 1, p. 41-47 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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European Lipoprotein Club: Report of the 34th ELC annual conference, Tutzing, 5-8 September 2011
Bernini, F., Costet, P., Ehrenborg, E., Fisher, R., Fielding, B., Freeman, D., Groen, A., Malle, E., Mulder, M., Niemeier, A., Tybjærg-Hansen, Anne & von Eckardstein, A., 2012, In: Atherosclerosis. 221, p. 287-93Research output: Contribution to journal › Journal article › Research
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Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis
Kjaergaard, A., Ellervik, C., Tybjaerg-Hansen, A., Axelsson, C., Grønholdt, M., Grande, P., Jensen, G. B., Nordestgaard, B., Tybjærg-Hansen, Anne, Kjaergaard, A. D., Ellervik, Christina, Axelsson, C. K., Grønholdt, M., Grande, P. & Nordestgaard, Børge, 2007, In: Circulation. 115, 7, p. 861-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies
Pennells, L., Kaptoge, S., Wood, A., Sweeting, M., Zhao, X., White, I., Burgess, S., Willeit, P., Bolton, T., Moons, K. G. M., van der Schouw, Y. T., Selmer, R., Khaw, K-T., Gudnason, V., Assmann, G., Amouyel, P., Salomaa, V., Kivimaki, M., Nordestgaard, B. G., Blaha, M. J. & 255 others, , 2019, In: European Heart Journal. 40, 7, p. 621-631 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epigenetic Regulation of F2RL3 Associates with Myocardial Infarction and Platelet Function
Corbin, L. J., White, S. J., Taylor, A. E., Williams, C. M., Taylor, K., Van Den Bosch, M. T., Teasdale, J. E., Jones, M., Bond, M., Harper, M. T., Falk, L., Groom, A., Hazell, G. G. J., Paternoster, L., Munafò, M. R., Nordestgaard, B. G., Tybjærg-Hansen, A., Bojesen, S. E., Relton, C., Min, J. L. & 4 others, , 2022, In: Circulation Research. 130, 3, p. 384-400 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Endogenous sex hormones and risk of venous thromboembolism in women and men
Holmegard, H. N., Nordestgaard, Børge, Schnohr, P., Tybjærg-Hansen, Anne & Benn, Marianne, 2014, In: Journal of Thrombosis and Haemostasis. 12, 3, p. 297-305 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated transferrin saturation and risk of diabetes: three population-based studies
Ellervik, Christina, Mandrup-Poulsen, T., Andersen, H. U., Tybjærg-Hansen, Anne, Frandsen, M. M., Birgens, H. & Nordestgaard, Børge, 2011, In: Diabetes Care. 34, 10, p. 2256-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated transferrin saturation and risk of diabetes: Three population-based studies
Ellervik, Christina, Mandrup-Poulsen, Thomas, Andersen, H. U., Tybjærg-Hansen, Anne, Frandsen, M., Birgens, H. & Nordestgaard, Børge, 2011, In: Diabetes Care. 34, 10, p. 2256-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated plasma fibrinogen associated with reduced pulmonary function and increased risk of chronic obstructive pulmonary disease
Dahl, M., Tybjærg-Hansen, Anne, Vestbo, J., Lange, Peter & Nordestgaard, Børge, 15 Sep 2001, In: American Journal of Respiratory and Critical Care Medicine. 164, 6, p. 1008-11 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population
Kamstrup, P. R., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 11 Feb 2014, In: Journal of the American College of Cardiology. 63, 5, p. 470-477 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated body mass index as a causal risk factor for symptomatic gallstone disease: A Mendelian randomization study
Stender, Stefan, Nordestgaard, B. G. & Tybjærg-Hansen, Anne, 2013, In: Hepatology. 58, 6, p. 2133–2141Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated Remnant Cholesterol Causes Both Low-Grade Inflammation and Ischemic Heart Disease, Whereas Elevated Low-Density Lipoprotein Cholesterol Causes Ischemic Heart Disease Without Inflammation
Varbo, A., Benn, Marianne, Tybjærg-Hansen, Anne, Nordestgaard, Børge & Benn, Marianne, 2013, In: Circulation. 128, 12, p. 1298-1309 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis
Klovaite, J., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Benn, M., 2013, In: American Journal of Respiratory and Critical Care Medicine. 187, 3, p. 286-93Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated Apolipoprotein A1 and HDL Cholesterol Associated with Age-related Macular Degeneration: 2 Population Cohorts
Nordestgaard, L. T., Tybjærg-Hansen, Anne, Frikke-Schmidt, Ruth & Nordestgaard, Børge, 16 Jun 2021, In: The Journal of clinical endocrinology and metabolism. 106, 7, p. e2749-e2758 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of APOE ε Genotype on Lipoprotein(a) and the Associated Risk of Myocardial Infarction and Aortic Valve Stenosis
Kritharides, L., Nordestgaard, Børge, Tybjærg-Hansen, Anne, Kamstrup, P. R. & Afzal, Shoaib, 1 Sep 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 9, p. 3390-3399 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype
Timpson, N. J., Harbord, R., Davey Smith, G., Zacho, J., Tybjærg-Hansen, Anne & Nordestgaard, B. G., 2009, In: Hypertension. 54, 1, p. 84-90 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Does elevated C-reactive protein increase atrial fibrillation risk? A Mendelian randomization of 47,000 individuals from the general population
Marott, S. C. W., Nordestgaard, Børge, Zacho, J., Friberg, Jens Birkedal, Jensen, G. B., Tybjærg-Hansen, Anne, Benn, Marianne & Benn, M., 31 Aug 2010, In: Journal of the American College of Cardiology. 56, 10, p. 789-95 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diabetes mellitus, fasting glucose, and risk of cause-specific death
Seshasai, S. R. K., Kaptoge, S., Thompson, A., Di Angelantonio, E., Gao, P., Sarwar, N., Whincup, P. H., Mukamal, K. J., Gillum, R. F., Holme, I., Njølstad, I., Fletcher, A., Nilsson, C. M. P., Lewington, S., Collins, R., Gudnason, V., Thompson, S. G., Sattar, N., Selvin, E., Hu, F. B. & 7 others, , 2011, In: New England Journal of Medicine. 364, 9, p. 829-41 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
Sarwar, N., Gao, P., Seshasai, S. R. K., Gobin, R., Kaptoge, S., Di Angelantonio, E., Ingelsson, E., Lawlor, D. A., Selvin, E., Stampfer, M., Stehouwer, C. D. A., Lewington, S., Pennells, L., Thompson, A., Sattar, N., White, I. R., Ray, K. K., Danesh, J., Jørgensen, T., Emerging Risk Factors Collaboration & 3 others, , 26 Jun 2010, In: Lancet. 375, 9733, p. 2215-22 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DeltaF508 heterozygosity in cystic fibrosis and susceptibility to asthma
Dahl, M., Tybjærg-Hansen, Anne, Lange, Peter & Nordestgaard, Børge, 27 Jun 1998, In: Lancet. 351, 9120, p. 1911-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Mar 2016, In: Data in Brief. 6, p. 923-932 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cystic fibrosis ΔF508 heterozygotes, smoking, and reproduction: studies of 9141 individuals from a general population sample
Dahl, M., Tybjærg-Hansen, Anne, Wittrup, H. H., Lange, Peter & Nordestgaard, Børge, 1998, In: Genomics. 50, 1, p. 89-96 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies
Tybjærg-Hansen, Anne, 2009, In: Statistics in Medicine. 28, 7, p. 1067-1092 25 p.Research output: Contribution to journal › Journal article › Research
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Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population
Nørskov, M. S., Frikke-Schmidt, Ruth, Bojesen, Stig Egil, Nordestgaard, Børge, Loft, Steffen & Tybjærg-Hansen, Anne, 2011, In: Pharmacogenomics Journal. 11, 4, p. 292-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses
Nørskov, M. S., Frikke-Schmidt, Ruth, Loft, Steffen, Sillesen, Henrik, Grande, P., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2011, In: Circulation: Cardiovascular Genetics. 4, 4, p. 418-28 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 924951
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ABCA7 and risk of dementia and vascular disease in the Danish population
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The UK10K project identifies rare variants in health and disease
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Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease
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