Anne Tybjærg-Hansen

Anne Tybjærg-Hansen

Clinical Professor

Member of:

  • Clinical Biochemistry


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  1. Published

    Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism

    Steiner, C., Holleboom, A. G., Karuna, R., Motazacker, M. M., Kuivenhoven, J. A., Frikke-Schmidt, R., Tybjærg-Hansen, Anne, Rohrer, L., Rentsch, K. M. & von Eckardstein, A., 2012, In: Clinical Science. 122, 8, p. 385-96 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Lipoprotein(a) Levels at Birth and in Early Childhood: The COMPARE Study

    Strandkjær, N., Hansen, M. K., Nielsen, S. T., Frikke-Schmidt, Ruth, Tybjærg-Hansen, Anne, Nordestgaard, Børge, Tabor, Ann, Bundgård, Henning, Iversen, Kasper & Kamstrup, P. R., 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 2, p. 324-335 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Lipoprotein(a) and familial hypercholesterolaemia - Authors' reply

    Langsted, A., Kamstrup, P. R., Benn, Marianne, Tybjærg-Hansen, Anne & Nordestgaard, Børge, Sep 2016, In: The Lancet Diabetes and Endocrinology. 4, 9, p. 730-731 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  4. Published

    Lipoprotein(a) and risk of myocardial infarction--genetic epidemiologic evidence of causality

    Kamstrup, P. R., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2011, In: Scandinavian Journal of Clinical & Laboratory Investigation. 71, 2, p. 87-93 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Lipoprotein(a) as a cardiovascular risk factor: current status

    Nordestgaard, Børge, Chapman, M. J., Ray, K., Borén, J., Andreotti, F., Watts, G. F., Ginsberg, H., Amarenco, P., Catapano, A., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., Lesnik, P., Masana, L., Reiner, Z., Taskinen, M., Tokgözoglu, L., Tybjærg-Hansen, Anne & European Atherosclerosis Society Consensus Panel, E. A. S. C. P., 1 Dec 2010, In: European Heart Journal. 31, 23, p. 2844-53 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality

    (Tybjaerg-Hansen, A. ). T. F. S. C. T. C. C. H. S. & Tybjærg-Hansen, Anne, 2009, In: JAMA - Journal of the American Medical Association. 302, 4, p. 412-423 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals

    Lauridsen, B. K., Stender, Steen, zwp671, zwp671, Kofoed, Klaus Fuglsang, Køber, Lars Valeur, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2018, In: European Heart Journal. 39, 5, p. 385-393 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Long-term Benefits and Harms Associated with Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population

    Nordestgaard, L. T., Christoffersen, M., Lauridsen, B. K., Afzal, Shoaib, Nordestgaard, Børge, Frikke-Schmidt, Ruth & Tybjærg-Hansen, Anne, 2022, In: JAMA Cardiology. 7, 1, p. 55-64

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease

    Jørgensen, A. B., Frikke-Schmidt, Ruth, Nordestgaard, Børge & Tybjærg-Hansen, Anne, Jul 2014, In: New England Journal of Medicine. 371, 1, p. 32-41 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

    Nordestgaard, L. T., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Dec 2015, In: Alzheimer's & Dementia. 11, 12, p. 1430-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Low LDL Cholesterol by PCSK9 Variation Reduces Cardiovascular Mortality

    Benn, Marianne, Tybjærg-Hansen, Anne & Nordestgaard, Børge, Jun 2019, In: Journal of the American College of Cardiology. 73, 24, p. 3102-3114

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study

    Benn, Marianne, Nordestgaard, Børge, Frikke-Schmidt, Ruth & Tybjærg-Hansen, Anne, 24 Apr 2017, In: B M J. 357, 11 p., j1648.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Low Nonfasting Triglycerides and Reduced All-Cause Mortality: A Mendelian Randomization Study

    Thomsen, M., Varbo, A., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2014, In: Clinical Chemistry. 60, 5, p. 737-746 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Low and high pancreatic amylase is associated with pancreatic cancer and chronic pancreatitis

    Hansen, S. E. J., Langsted, A., Varbo, A., Madsen, C. M., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2021, In: European Journal of Epidemiology. 36, p. 975–984

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Low-density lipoprotein cholesterol and risk of gallstone disease: A Mendelian randomization study and meta-analyses

    Stender, S., Frikke-Schmidt, R., Benn, M., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2013, In: Journal of Hepatology. 58, 1, p. 126-33 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study

    Benn, Marianne, Tybjærg-Hansen, Anne, Stender, Stefan, Frikke-Schmidt, Ruth, Nordestgaard, Børge & Benn, M., 16 Mar 2011, In: National Cancer Institute. Journal (Print). 103, 6, p. 508-19 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Macular Degeneration and CETP Inhibition-Reply

    Nordestgaard, L. T., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2022, In: JAMA Cardiology. 7, 7, p. 775-776 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  18. Published

    Major lipids, apolipoproteins and risk of vascular disease.

    (Tybjaerg-Hansen, A. ). T. E. R. F. C. T. C. C. H. S. & Tybjærg-Hansen, Anne, 2009, In: JAMA - Journal of the American Medical Association. 302, p. 1993-2000 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Measures to assess the prognostic ability of the stratified Cox proportional hazards model

    (Tybjaerg-Hansen, A. ). T. F. S. C. T. C. C. H. S. & Tybjærg-Hansen, Anne, 2009, In: Statistics in Medicine. 28, 3, p. 389-411 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Medullary thyroid cancer: RET testing of an archival material

    Godballe, C., Jørgensen, G., Gerdes, Anne-Marie Axø, Krogdahl, A. S., Tybjærg-Hansen, Anne & Nielsen, Finn Cilius, 1 Apr 2010, In: European Archives of Oto-Rhino-Laryngology. 267, 4, p. 613-7 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Mendelsk randomisering - eller hvordan man kan bruge gener til at sandsynliggøre kausalitet.

    Tybjærg-Hansen, Anne, May 2010, In: DSKB-Nyt. 2, p. 18-21 4 p.

    Research output: Contribution to journal › Journal article › Research

  22. Published

    Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study

    Frederiksen, J., Juul, K., Grande, P., Jensen, G. B., Schroeder, T. V., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 15 Nov 2004, In: Blood. 104, 10, p. 3046-51 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

    Gaziano, L., Sun, L., Arnold, M., Bell, S., Cho, K., Kaptoge, S. K., Song, R. J., Burgess, S., Posner, D. C., Mosconi, K., Robinson-Cohen, C., Mason, A. M., Bolton, T. R., Tao, R., Allara, E., Schubert, P., Chen, L., Staley, J. R., Staplin, N., Altay, S. & 30 others, Amiano, P., Arndt, V., Ärnlöv, J., Barr, E. L. M., Björkelund, C., Boer, J. M. A., Brenner, H., Casiglia, E., Chiodini, P., Cooper, J. A., Coresh, J., Cushman, M., Dankner, R., Davidson, K. W., De Jongh, R. T., Donfrancesco, C., Engström, G., Freisling, H., De La Cámara, A. G., Gudnason, V., Hankey, G. J., Hansson, P. O., Heath, A. K., Hoorn, E. J., Kyrø, C., Nordestgaard, Børge, Tjønneland, Anne, Tybjærg-Hansen, Anne, Afzal, Shoaib & Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program, E. R. F. C. V. P., 2022, In: Circulation. 146, 20, p. 1507-1517 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Missense polymorphisms in BRCA1 and BRCA2 and risk of breast and ovarian cancer

    Dombernowsky, S. L., Weischer, M., Freiberg, J. J., Bojesen, Stig Egil, Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2009, In: Cancer Epidemiology, Biomarkers & Prevention. 18, 8, p. 2339-42 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Missense variants in plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy patients - disease - causing or innocent bystanders?

    Christensen, A. H., Benn, Marianne, Tybjærg-Hansen, Anne, Haunso, S. & Svendsen, J. H., 2009, In: Cardiology. 115, 2, p. 148-154 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Missense variants in plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy patients--disease-causing or innocent bystanders?

    Christensen, Alex Hørby, Benn, Marianne, Tybjærg-Hansen, Anne, Haunso, S., Svendsen, Jesper Hastrup, Christensen, A. H., Benn, M., Tybjærg-Hansen, Anne, Haunso, S. & Svendsen, Jesper Hastrup, 1 Jan 2010, In: Cardiology. 115, 2, p. 148-54 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Mitochondrial haplogroups: ischemic cardiovascular disease, other diseases, mortality, and longevity in the general population

    Benn, M., Schwartz, M., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2008, In: Circulation. 117, 19, p. 2492-501 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Modifications to the Patient Rule-Induction Method that utilize non-additive combinations of genetic and environmental effects to define partitions that predict ischemic heart disease

    Dyson, G., Frikke-Schmidt, Ruth, Nordestgaard, B. G., Tybjærg-Hansen, Anne & Sing, C. F., 2009, In: Genetic Epidemiology. 33, 4, p. 317-24 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Molecular diagnosis of intermediate and severe alpha(1)-antitrypsin deficiency: MZ individuals with chronic obstructive pulmonary disease may have lower lung function than MM individuals

    Dahl, M., Nordestgaard, Børge, Lange, Peter, Vestbo, J. & Tybjærg-Hansen, Anne, Jan 2001, In: Clinical Chemistry. 47, 1, p. 56-62 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Molecular diagnosis of intermediate and severe α<inf>1</inf>-antitrypsin deficiency: MZ individuals with chronic obstructive pulmonary disease may have lower lung function than MM individuals

    Dahl, Morten, Nordestgaard, Børge, Lange, Peter, Vestbo, J. & Tybjærg-Hansen, Anne, 2001, In: Clinical Chemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Morbiditet og mortalitet hos personer med mannosebindende lektinmangel. Osterbroundersøgelsen

    Dahl, M., Tybjærg-Hansen, Anne, Schnohr, P. & Nordestgaard, Børge, 6 Dec 2004, In: Ugeskrift for Laeger. 166, 50, p. 4606-9 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Mutation analysis and evaluation of the cardiac localization of TMEM43 in arrhythmogenic right ventricular cardiomyopathy

    Christensen, Alex Hørby, Andersen, C. B., Tybjærg-Hansen, Anne, Haunso, S. & Svendsen, Jesper Hastrup, 2011, In: Clinical Genetics. 80, 3, p. 256-64 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Mutation in APOA1 predicts increased risk of ischaemic heart disease and mortality without low HDL cholesterol

    Haase, C. L., Frikke-Schmidt, Ruth, Nordestgaard, Børge, Kateifides, A. K., Kardassis, D., Nielsen, L. B., Johnsen, A. H., Grande, P., Zannis, V. I., Tybjaerg-Hansen, A., Johnsen, A. H. & Tybjærg-Hansen, Anne, 2010, In: Amyloid: the Journal of Protein Folding Disorders. 17, p. 129 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  34. Published

    Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels

    Haase, C. L., Frikke-Schmidt, Ruth, Nordestgaard, Børge, Kateifides, A. K., Kardassis, D., Nielsen, L. B., Andersen, C. B., Køber, Lars Valeur, Johnsen, A. H., Grande, P., Zannis, V. I. & Tybjærg-Hansen, Anne, 2011, In: Journal of Internal Medicine. 270, 2, p. 136-46 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Mutation in apolipoprotein B associated with hypobetalipoproteinemia despite decreased binding to the low density lipoprotein receptor

    Benn, M., Nordestgaard, Børge, Jensen, J. S., Nilausen, K. S., Meinertz, H. & Tybjærg-Hansen, Anne, 2005, In: Journal of Biological Chemistry. 280, 22, p. 21052-60 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Mutations causative of familial hypercholesterolaemia: screening of 98 098 individuals from the Copenhagen General Population Study estimated a prevalence of 1 in 217

    Benn, M., Watts, G. F., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 1 May 2016, In: European Heart Journal. 37, 17, p. 1384-94 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2

    Christiansen, M., Hedley, P. L., Theilade, J., Stoevring, B., Leren, T. P., Eschen, O., Sørensen, K. M., Tybjærg-Hansen, Anne, Ousager, L. B., Pedersen, L. N., Frikke-Schmidt, Ruth, Aidt, F. H., Hansen, M. G., Hansen, J., Bloch Thomsen, P. E., Toft, E., Henriksen, F. L., Bundgård, Henning, Jensen, H. K. & Kanters, Jørgen K., 2014, In: BMC Medical Genetics. 15, 11 p., 31.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans

    Oldoni, F., van Capelleveen, J. C., Dalila, N., Wolters, J. C., Heeren, J., Sinke, R. J., Hui, D. Y., Dallinga-Thie, G. M., Frikke-Schmidt, Ruth, Hovingh, K. G., van de Sluis, B., Tybjærg-Hansen, Anne & Kuivenhoven, J. A., 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 7, p. 1440-1453 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Neutrophil counts and cardiovascular disease

    Luo, J., Thomassen, J. Q., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2023, In: European Heart Journal. 44, 47, p. 4953-4964 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study

    Kaur-Knudsen, D., Bojesen, Stig Egil, Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2011, In: Journal of Clinical Oncology. 29, 21, p. 2875-82 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Nonfasting Triglycerides and Risk of Ischemic Stroke in the General Population

    Freiberg, J. J., Tybjærg-Hansen, Anne, Jensen, J. S. & Nordestgaard, B. G., 2008, In: JAMA - Journal of the American Medical Association. 300, 18, p. 2142-2152 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Nonfasting Triglycerides remnant lipoproteins, and cardiovascular disease

    Tybjærg-Hansen, Anne, Nordestgaard, B. G. & Nordestgaard, Børge, 2009, In: Klinisk Kemi i Norden. 21, 3, p. 10-16 7 p.

    Research output: Contribution to journal › Journal article › Research

  43. Published

    Nonfasting cholesterol and triglycerides and association with risk of myocardial infarction and total mortality: the Copenhagen City Heart Study with 31 years of follow-up

    Langsted, A., Freiberg, J. J., Tybjaerg-Hansen, A., Schnohr, P., Jensen, G. B., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 1 Jul 2011, In: Journal of Internal Medicine. 270, 1, p. 65-75 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study

    Benn, M., Tybjærg-Hansen, Anne, McCarthy, M. I., Jensen, G. B., Grande, P. & Nordestgaard, Børge, 2012, In: Journal of the American College of Cardiology. 59, 25, p. 2356-65 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women

    Nordestgaard, Børge, Benn, M., Schnohr, P. & Tybjærg-Hansen, Anne, 2007, In: J A M A: The Journal of the American Medical Association. 298, 3, p. 299-308 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population

    Varbo, A., Nordestgaard, Børge, Tybjærg-Hansen, Anne, Schnohr, P., Jensen, G. B., Benn, M. & Benn, M., 1 Apr 2011, In: Annals of Neurology. 69, 4, p. 628-34 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Nose and blood pressure

    Dahl, M., Tybjærg-Hansen, Anne, Nordestgaard, Børge, Lange, Peter & Vestbo, J., 15 Jan 2004, In: American Journal of Respiratory and Critical Care Medicine. 169, 2, p. 318; author reply 319

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Novel genes in LDL metabolism: a comprehensive overview

    Christoffersen, M. & Tybjærg-Hansen, Anne, Jun 2015, In: Current Opinion in Lipidology. 26, 3, p. 179-87 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals

    Freiberg, J. J., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 1 Aug 2010, In: Journal of Thrombosis and Haemostasis. 8, 8, p. 1694-701 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Obesity increases heart failure incidence and mortality: observational and Mendelian randomization studies totalling over 1 million individuals

    Benn, Marianne, Marott, S. C. W., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2022, In: Cardiovascular Research. 118, 18, p. 3576-3585 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 924951