Anne Tybjærg-Hansen
Clinical Professor
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High lipoprotein(a) as a possible cause of clinical familial hypercholesterolaemia: a prospective cohort study
Langsted, A., Kamstrup, P. R., Benn, Marianne, Tybjærg-Hansen, Anne & Nordestgaard, Børge, Jul 2016, In: The Lancet Diabetes and Endocrinology. 4, 7, p. 577-587 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis
Langsted, A., Nordestgaard, Børge, Benn, Marianne, Tybjærg-Hansen, Anne & Kamstrup, P. R., Sep 2016, In: The Journal of clinical endocrinology and metabolism. 101, 9, p. 3281-3287 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variation in NPC1L1 and Risk of Gallstone Disease
Lauridsen, B. K., Stender, S. & Tybjærg-Hansen, Anne, 1 Sep 2015, In: Journal of the American College of Cardiology. 66, 9, p. 1086 1 p.Research output: Contribution to journal › Letter › Research › peer-review
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Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease
Lauridsen, B. K., Stender, S., Frikke-Schmidt, Ruth, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 1 Jul 2015, In: European Heart Journal. 36, 25, p. 1601-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals
Lauridsen, B. K., Stender, Steen, zwp671, zwp671, Kofoed, Klaus Fuglsang, Køber, Lars Valeur, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2018, In: European Heart Journal. 39, 5, p. 385-393 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults
Lawlor, D. A., Harbord, R. M., Tybjærg-Hansen, Anne, Palmer, T. M., Zacho, J., Benn, M., Timpson, N. J., Smith, G. D., Nordestgaard, Børge & Benn, M., 2011, In: Journal of Internal Medicine. 269, 5, p. 525-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study
Lawlor, D. A., Nordestgaard, Børge, Benn, Marianne, Zuccolo, L., Tybjærg-Hansen, Anne & Davey Smith, G., 14 Mar 2013, In: European Heart Journal (Online).Research output: Contribution to journal › Journal article › Research › peer-review
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Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease
Lee, J., Dahl, M., Grande, P., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2010, In: Stroke. 41, 1, p. 27-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetically Reduced Soluble Epoxide Hydrolase Activity and Risk of Stroke and Other Cardiovascular Disease
Lee, J., Dahl, Morten, Grande, P., Tybjærg-Hansen, Anne & Nordestgaard, B. G., Jan 2010, In: Stroke. 41, 1, p. 27-33Research output: Contribution to journal › Journal article › Research › peer-review
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The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts
Lewis, S. J., Lawlor, D. A., Nordestgaard, B. G., Tybjærg-Hansen, Anne, Ebrahim, S., Zacho, J., Ness, A., Leary, S. & Smith, G. D., 2008, In: European Journal of Endocrinology. 159, 1, p. 35-40 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exome-wide association study of plasma lipids in >300,000 individuals
Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 208 others, , 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1758-1766 9 p.Research output: Contribution to journal › Letter › Research › peer-review
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Genetically elevated apolipoprotein A-I, high-density lipoprotein cholesterol levels, and risk of ischemic heart disease
Lundegaard, C., Tybjærg-Hansen, Anne, Grande, P. & Frikke-Schmidt, Ruth, 1 Dec 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 12, p. E500-10Research output: Contribution to journal › Journal article › Research › peer-review
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Neutrophil counts and cardiovascular disease
Luo, J., Thomassen, J. Q., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2023, In: European Heart Journal. 44, 47, p. 4953-4964 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reply to “Mendelian randomization highlights causal association between genetically increased C-reactive protein levels and reduced Alzheimer's disease risk”
Luo, J., Thomassen, J. Q., Hegazy, S. H., Rasmussen, I. J., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2022, In: Alzheimer's & Dementia. 18, 10, p. 2007-2009 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Blood Leukocyte Counts in Alzheimer Disease
Luo, J., Thomassen, J. Q., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2022, In: JAMA network open. 5, 10, 14 p., E2235648.Research output: Contribution to journal › Journal article › Research › peer-review
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Validated context-dependent associations of coronary heart disease risk with genotype variation in the chromosome 9p21 region: the Atherosclerosis Risk in Communities study
Lusk, C. M., Dyson, G., Clark, A. G., Ballantyne, C. M., Frikke-Schmidt, Ruth, Tybjærg-Hansen, Anne, Boerwinkle, E. & Sing, C. F., Sep 2014, In: Human Genetics. 133, 9, p. 1105-1116 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies
Madsen, C. M., Varbo, A., Tybjærg-Hansen, Anne, Frikke-Schmidt, Ruth & Nordestgaard, Børge, 2018, In: European Heart Journal. 39, 14, p. 1181-1190 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., Guo, X., Lu, Y., Li, M., Jensen, R. A., Hu, Y., Huo, S., Lohman, K. K., Zhang, W., Cook, J. P., Prins, B. P. & 32 others, , Apr 2018, In: Nature Genetics. 50, 4, p. 559-571 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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AT1 mutations and risk of atrial fibrillation based on genotypes from 71,000 individuals from the general population
Marott, S. C. W., Nordestgaard, Børge, Jensen, G. B., Tybjærg-Hansen, Anne & Benn, M., 2013, In: British Journal of Clinical Pharmacology. p. Epub ahead of printResearch output: Contribution to journal › Journal article › Research › peer-review
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Does elevated C-reactive protein increase atrial fibrillation risk? A Mendelian randomization of 47,000 individuals from the general population
Marott, S. C. W., Nordestgaard, Børge, Zacho, J., Friberg, Jens Birkedal, Jensen, G. B., Tybjærg-Hansen, Anne, Benn, Marianne & Benn, M., 31 Aug 2010, In: Journal of the American College of Cardiology. 56, 10, p. 789-95 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Causal Associations in Type 2 Diabetes Development
Marott, S. C. W., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Benn, Marianne, 2019, In: The Journal of clinical endocrinology and metabolism. 104, 4, p. 1313-1324Research output: Contribution to journal › Journal article › Research › peer-review
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YKL-40 levels and atrial fibrillation in the general population
Marott, S. C. W., Benn, M., Johansen, J. S., Jensen, G. B., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2013, In: International Journal of Cardiology.Research output: Contribution to journal › Journal article › Research › peer-review
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Components of the Metabolic Syndrome and Risk of Type 2 Diabetes
Marott, S. C. W., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Benn, Marianne, Aug 2016, In: The Journal of clinical endocrinology and metabolism. 101, 8, p. 3212-3221 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rare and low-frequency coding variants alter human adult height
Marouli, E., Graff, M., Medina-Gomez, C., Lo, K. S., Wood, A. R., Kjaer, T. R., Fine, R. S., Lu, Y., Schurmann, C., Highland, H. M., Rüeger, S., Thorleifsson, G., Justice, A. E., Lamparter, D., Stirrups, K. E., Turcot, V., Young, K. L., Winkler, T. W., Esko, T., Karaderi, T. & 31 others, , 9 Feb 2017, In: Nature. 542, 7640, p. 186-190 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Autosomal recessive hypercholesterolemia in a kindred of Syrian ancestry
Martinsen, M. H., Klausen, I. C., Tybjærg-Hansen, Anne & Hedegaard, B. S., 2020, In: Journal of Clinical Lipidology. 14, 4, p. 419-424Research output: Contribution to journal › Journal article › Research › peer-review
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Genetics of Coronary Artery Disease
McPherson, R. & Tybjærg-Hansen, Anne, 18 Feb 2016, In: Circulation Research. 118, 4, p. 564-578 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stroke genetics informs drug discovery and risk prediction across ancestries
Mishra, A., Malik, R., Hachiya, T., Jürgenson, T., Namba, S., Posner, D. C., Kamanu, F. K., Koido, M., Le Grand, Q., Shi, M., He, Y., Georgakis, M. K., Caro, I., Krebs, K., Liaw, Y. C., Vaura, F. C., Lin, K., Winsvold, B. S., Srinivasasainagendra, V., Parodi, L. & 45 others, , 2022, In: Nature. 611, 7934, p. 115-123 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Statin Eligibility for Primary Prevention of Cardiovascular Disease According to 2021 European Prevention Guidelines Compared with Other International Guidelines
Mortensen, M. B., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2022, In: JAMA Cardiology. 7, 8, p. 836-843Research output: Contribution to journal › Journal article › Research › peer-review
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Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations
Motazedi, E., Cheng, W., Thomassen, J. Q., Frei, O., Rongve, A., Athanasiu, L., Bahrami, S., Shadrin, A., Ulstein, I., Stordal, E., Brækhus, A., Saltvedt, I., Sando, S. B., O'Connell, K. S., Hindley, G., Van Der Meer, D., Bergh, S., Nordestgaard, B. G., Tybjærg-Hansen, A., Brthen, G. & 10 others, , 2022, In: Journal of Alzheimer's Disease. 88, 4, p. 1533-1544Research output: Contribution to journal › Journal article › Research › peer-review
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Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies
Murabito, J. M., White, C. C., Kavousi, M., Sun, H. Y., Feitosa, M. F., Nambi, V., Lamina, C., Schillert, A., Coassin, S., Bis, J. C., Broer, L., Crawford, D. C., Franceschini, N., Frikke-Schmidt, R., Haun, M., Holewijn, S., Huffman, J. E., Hwang, S-J., Kiechl, S., Kollerits, B. & 109 others, , 2012, In: Circulation: Cardiovascular Genetics. 5, p. 100-112Research output: Contribution to journal › Journal article › Research › peer-review
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Serum soluble CD163 predicts risk of type 2 diabetes in the general population
Møller, H. J., Frikke-Schmidt, Ruth, Moestrup, S., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 1 Feb 2011, In: Clinical Chemistry. 57, 2, p. 291-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Significance of lipids, lipoproteins, and apolipoproteins during the first 14–16 months of life
Nielsen, S. T., Lytsen, R. M., Strandkjær, N., Rasmussen, I. J., Sillesen, A. S., B. Vøgg, R. O., Raja, A. A., Nordestgaard, Børge, Kamstrup, P. R., Iversen, Kasper, Bundgård, Henning, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2023, In: European Heart Journal. 44, 42, p. 4408-4418 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study
Nordestgaard, A. T., Stender, Stefan, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2020, In: Journal of Internal Medicine. 287, 1, p. 42-53Research output: Contribution to journal › Journal article › Research › peer-review
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Triglycerider målt hos ikkefastende og risiko for myokardieinfarkt, iskaemisk hjertesygdom og død blandt kvinder og maend--sekundaerpublikation
Nordestgaard, Børge, Benn, M., Schnohr, P. & Tybjærg-Hansen, Anne, 2007, In: Ugeskrift for Laeger. 169, 45, p. 3865-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease Consensus Statement of the European Atherosclerosis Society
Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., Wiegman, A., Santos, R. D., Watts, G. F., Parhofer, K. G., Hovingh, G. K., Kovanen, P. T., Boileau, C., Averna, M., Borén, J., Bruckert, E. & 9 others, , 2013, In: European Heart Journal. 34, 45, p. 3478-3490Research output: Contribution to journal › Journal article › Research › peer-review
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Lipoprotein(a) as a cardiovascular risk factor: current status
Nordestgaard, Børge, Chapman, M. J., Ray, K., Borén, J., Andreotti, F., Watts, G. F., Ginsberg, H., Amarenco, P., Catapano, A., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., Lesnik, P., Masana, L., Reiner, Z., Taskinen, M., Tokgözoglu, L., Tybjærg-Hansen, Anne & European Atherosclerosis Society Consensus Panel, E. A. S. C. P., 1 Dec 2010, In: European Heart Journal. 31, 23, p. 2844-53 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach
Nordestgaard, Børge, Palmer, T. M., Benn, M., Zacho, J., Tybjærg-Hansen, Anne, Davey Smith, G. & Timpson, N. J., 2012, In: P L o S Medicine. 9, 5, p. e1001212Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk
Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2011, In: Current Opinion in Lipidology. 22, 2, p. 113-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
Nordestgaard, Børge, Benn, M., Schnohr, P. & Tybjærg-Hansen, Anne, 2007, In: J A M A: The Journal of the American Medical Association. 298, 3, p. 299-308 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Advances in lipid-lowering therapy through gene-silencing technologies
Nordestgaard, Børge, Nicholls, S. J., Langsted, A., Ray, K. K. & Tybjærg-Hansen, Anne, 2018, In: Nature Reviews Cardiology. 15, p. 261-272Research output: Contribution to journal › Review › Research › peer-review
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Genetic variation in ABCA1 and risk of all-cause dementia, age-related macular degeneration, and ischemic heart disease
Nordestgaard, L. T., Christoffersen, M., Afzal, Shoaib, Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2021, In: Atherosclerosis. 331, p. E38-E39 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Triglycerides as a Shared Risk Factor between Dementia and Atherosclerotic Cardiovascular Disease: A Study of 125 727 Individuals
Nordestgaard, L. T., Christoffersen, M., Afzal, Shoaib, Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2021, In: Clinical Chemistry. 67, 1, p. 245-255 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cholesteryl Ester Transfer Protein Inhibitors and Access to the Retina in Age-Related Macular Degeneration-Reply
Nordestgaard, L. T., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2023, In: JAMA Cardiology. 8, 2, p. 206-207Research output: Contribution to journal › Comment/debate › Research › peer-review
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Body mass index and risk of Alzheimer's disease: A mendelian randomization study of 399,536 individuals
Nordestgaard, L. T., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Jul 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 7, p. 2310-2320 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: Cohort studies and meta-analyses of 362,338 individuals
Nordestgaard, L. T., Tybjærg-Hansen, Anne, Rasmussen, K. L., Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2018, In: BMC Medicine. 16, 11 p., 39.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease
Nordestgaard, L. T., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Dec 2015, In: Alzheimer's & Dementia. 11, 12, p. 1430-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variants in the adenosine triphosphate-binding cassette transporter A1 and risk of age-related macular degeneration
Nordestgaard, L. T., Christoffersen, M., Afzal, Shoaib, Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2023, In: European Journal of Epidemiology. 38, 9, p. 985-994 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated Apolipoprotein A1 and HDL Cholesterol Associated with Age-related Macular Degeneration: 2 Population Cohorts
Nordestgaard, L. T., Tybjærg-Hansen, Anne, Frikke-Schmidt, Ruth & Nordestgaard, Børge, 16 Jun 2021, In: The Journal of clinical endocrinology and metabolism. 106, 7, p. e2749-e2758 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term Benefits and Harms Associated with Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population
Nordestgaard, L. T., Christoffersen, M., Lauridsen, B. K., Afzal, Shoaib, Nordestgaard, Børge, Frikke-Schmidt, Ruth & Tybjærg-Hansen, Anne, 2022, In: JAMA Cardiology. 7, 1, p. 55-64Research output: Contribution to journal › Journal article › Research › peer-review
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Macular Degeneration and CETP Inhibition-Reply
Nordestgaard, L. T., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2022, In: JAMA Cardiology. 7, 7, p. 775-776 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
ID: 924951
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ABCA7 and risk of dementia and vascular disease in the Danish population
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The UK10K project identifies rare variants in health and disease
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Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease
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