Anne Tybjærg-Hansen
Clinical Professor
- 2021
- Published
Polygenic risk scores: how much do they add?
Christoffersen, M. & Tybjærg-Hansen, Anne, 2021, In: Current Opinion in Lipidology. 32, 3, p. 157-162 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe
Hageman, S., Pennells, L., Ojeda, F., Kaptoge, S., Kuulasmaa, K., de Vries, T., Xu, Z., Kee, F., Chung, R., Wood, A., McEvoy, J. W., Veronesi, G., Bolton, T., Dendale, P., Ference, B. A., Halle, M., Timmis, A., Vardas, P., Danesh, J., Graham, I. & 32 others, , 2021, In: European Heart Journal. 42, 25, p. 2439-2454 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement
Skrivankova, V. W., Richmond, R. C., Woolf, B. A. R., Yarmolinsky, J., Davies, N. M., Swanson, S. A., Vanderweele, T. J., Higgins, J. P. T., Timpson, N. J., Dimou, N., Langenberg, C., Golub, R. M., Loder, E. W., Gallo, V., Tybjærg-Hansen, Anne, Davey Smith, G., Egger, M. & Richards, J. B., 2021, In: JAMA - Journal of the American Medical Association. 326, 16, p. 1614-1621Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting IL-6 in patients at high cardiovascular risk
Christoffersen, M. & Tybjærg-Hansen, Anne, 2021, In: The Lancet. 397, 10289, p. 2025-2027 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
The Dynamic and Multifaceted Nature of Cardiovascular Disease and Using Genetic Testing to Inform Clinical Care: An International Perspective
Baudhuin, L. M., De Backer, J., Ingles, J., Milewicz, D. M. & Tybjærg-Hansen, Anne, 2021, In: Clinical Chemistry. 67, 1, p. 33-40 8 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Triglyceride-rich lipoproteins and their remnants: Metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies - a consensus statement from the European Atherosclerosis Society
Ginsberg, H. N., Packard, C. J., Chapman, M. J., Borén, J., Aguilar-Salinas, C. A., Averna, M., Ference, B. A., Gaudet, D., Hegele, R. A., Kersten, S., Lewis, G. F., Lichtenstein, A. H., Moulin, P., Nordestgaard, B. G., Remaley, A. T., Staels, B., Stroes, E. S. G., Taskinen, M-R., Tokgözoğlu, L. S., Tybjaerg-Hansen, A. & 2 others, , 2021, In: European Heart Journal. 42, 47, p. 4791-4806 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Triglycerides as a Shared Risk Factor between Dementia and Atherosclerotic Cardiovascular Disease: A Study of 125 727 Individuals
Nordestgaard, L. T., Christoffersen, M., Afzal, Shoaib, Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2021, In: Clinical Chemistry. 67, 1, p. 245-255 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study
Emanuelsson, F., Marott, S., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Benn, Marianne, Apr 2020, In: Diabetes Care. 43, 4, p. 894-902 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
APOE and dementia – resequencing and genotyping in 105,597 individuals
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2020, In: Alzheimer's and Dementia. 16, 12, p. 1624-1637 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor
Rimbert, A., Dalila, N., Wolters, J. C., Huijkman, N., Smit, M., Kloosterhuis, N., Riemsma, M., Van Der Veen, Y., Singla, A., Van Dijk, F., Frikke-Schmidt, Ruth, Burstein, E., Tybjærg-Hansen, Anne, Van De Sluis, B. & Kuivenhoven, J. A., 2020, In: European Heart Journal. 41, 9, p. 1040-1053 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Apolipoprotein M and Risk of Type 2 Diabetes
Hajny, Stefan, Christoffersen, M., Dalila, N., Nielsen, L. B., Tybjærg-Hansen, Anne & Christoffersen, Christina, 2020, In: Journal of Clinical Endocrinology & Metabolism. 105, 9, p. 3046-3057Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autosomal recessive hypercholesterolemia in a kindred of Syrian ancestry
Martinsen, M. H., Klausen, I. C., Tybjærg-Hansen, Anne & Hedegaard, B. S., 2020, In: Journal of Clinical Lipidology. 14, 4, p. 419-424Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study
Nordestgaard, A. T., Stender, Stefan, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2020, In: Journal of Internal Medicine. 287, 1, p. 42-53Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population
Gellert-Kristensen, H., Richardson, T. G., Davey Smith, G., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Stender, Steen, 2020, In: Hepatology. 72, 3, p. 845-856Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic Variation at PPP1R3B Increases Hepatic CT Attenuation and Interacts With Prandial Status on Plasma Glucose
Seidelin, A., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Stender, S., 2020, In: Journal of Clinical Endrocrinology and Metabolism. 105, 6, p. 1963–1972Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic variants in SUSD2 are associated with the risk of ischemic heart disease
Bruikman, C. S., Dalila, N., van Capelleveen, J. C., Kroon, J., Peter, J., Havik, S. R., Willems, M., Huisman, L. C., de Boer, O. J., Hovingh, G. K., Tybjærg-Hansen, Anne & Dallinga-Thie, G. M., 2020, In: Journal of Clinical Lipidology. 14, 4, p. 470-481Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase–Lowering Effect of a HSD17B13 Variant
Gellert-Kristensen, H., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Stender, S., 2020, In: Hepatology. 71, 1, p. 56-66 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of cardiovascular risk factors and genetics on 10-year absolute risk of dementia: risk charts for targeted prevention
Juul Rasmussen, I., Rasmussen, K. L., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2020, In: European Heart Journal. 41, 41, p. 4024-4033 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Repositioning of the global epicentre of non-optimal cholesterol
NCD Risk Factor Collaboration (NCD-RisC), N. R. F. C. (., Taddei, C., Zhou, B., Bixby, H., Nordestgaard, Børge, Benn, Marianne, Linneberg, Allan René, Tybjærg-Hansen, Anne, Cisneros, J. Z., Gregg, E. W., Ezzati, M. & Sørensen, Thorkild I.A., 2020, In: Nature. 582, 7810, p. 73-77Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The European heart journal: Leading the fight to reduce the global burden of cardiovascular disease
Crea, F., Badimon, L., Berry, C., de Caterina, R., Elliott, P. M., Hatala, R., Libby, P., Linde, C., Tybjærg-Hansen, Anne & EHJ Editorial Board, E. E. B., 2020, In: European Heart Journal. 41, 33, p. 3113-3116 4 p.Research output: Contribution to journal › Editorial › Research › peer-review
- 2019
- Published
Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105949 individuals from a white general population cohort
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 1 Sep 2019, In: European Heart Journal. 40, 33, p. 2813-2824 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of LDL Cholesterol on Microvascular Versus Macrovascular Disease: A Mendelian Randomization Study
Emanuelsson, F., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Benn, Marianne, Sep 2019, In: Journal of the American College of Cardiology. 74, 11, p. 1465-1476Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and Replication of Six Loci Associated With Gallstone Disease
Gellert-Kristensen, H., Dalila, N., Fallgaard Nielsen, S., Grønne Nordestgaard, B., Tybjærg-Hansen, Anne & Stender, S., Aug 2019, In: Hepatology. 70, 2, p. 597-609 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Low LDL Cholesterol by PCSK9 Variation Reduces Cardiovascular Mortality
Benn, Marianne, Tybjærg-Hansen, Anne & Nordestgaard, Børge, Jun 2019, In: Journal of the American College of Cardiology. 73, 24, p. 3102-3114Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blood–brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals
Juul Rasmussen, I., Tybjærg-Hansen, Anne, Rasmussen, K. L., Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2019, In: European Journal of Epidemiology. 34, 6, p. 579-590 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Causal Associations in Type 2 Diabetes Development
Marott, S. C. W., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Benn, Marianne, 2019, In: The Journal of clinical endocrinology and metabolism. 104, 4, p. 1313-1324Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined Association of Body Mass Index and Alcohol Consumption With Biomarkers for Liver Injury and Incidence of Liver Disease: A Mendelian Randomization Study
Carter, A. R., Borges, M., Benn, Marianne, Tybjærg-Hansen, Anne, Davey Smith, G., Nordestgaard, Børge & Lawlor, D. A., 2019, In: JAMA Network Open. 2, 3, 14 p., e190305.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies
Pennells, L., Kaptoge, S., Wood, A., Sweeting, M., Zhao, X., White, I., Burgess, S., Willeit, P., Bolton, T., Moons, K. G. M., van der Schouw, Y. T., Selmer, R., Khaw, K-T., Gudnason, V., Assmann, G., Amouyel, P., Salomaa, V., Kivimaki, M., Nordestgaard, B. G., Blaha, M. J. & 255 others, , 2019, In: European Heart Journal. 40, 7, p. 621-631 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing: A 2019 Expert Panel Statement, Main Text
Kolovou, G. D., Watts, G. F., Mikhailidis, D. P., Pérez-Martínez, P., Mora, S., Bilianou, H., Panotopoulos, G., Katsiki, N., Ooi, T. C., Lopez-Miranda, J., Tybjærg-Hansen, Anne, Tentolouris, N. & Nordestgaard, Børge, 2019, In: Current Vascular Pharmacology. 17, 5, p. 498-514Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing: A 2019 Expert Panel Statement, Narrative Review
Kolovou, G. D., Watts, G. F., Mikhailidis, D. P., Pérez-Martínez, P., Mora, S., Bilianou, H., Panotopoulos, G., Katsiki, N., Ooi, T. C., Lopez-Miranda, J., Tybjærg-Hansen, Anne, Tentolouris, N. & Nordestgaard, Børge, 2019, In: Current Vascular Pharmacology. 17, 5, p. 515-537Research output: Contribution to journal › Review › Research › peer-review
- Published
Postprandial Hypertriglyceridaemia Revisited in the Era of Non-fasting Lipid Profiles: Executive Summary of a 2019 Expert Panel Statement
Kolovou, G. D., Watts, G. F., Mikhailidis, D. P., Pérez-Martínez, P., Mora, S., Bilianou, H., Panotopoulos, G., Katsiki, N., Ooi, T. C., Lopez-Miranda, J., Tybjærg-Hansen, Anne, Tentolouris, N. & Nordestgaard, Børge, 2019, In: Current Vascular Pharmacology. 17, 5, p. 538-540Research output: Contribution to journal › Review › Research › peer-review
- Published
Residual vascular risk in diabetes: Will the SPPARM alpha concept hold the key?
Fruchart, J. C., Santos, R. D., Yamashita, S., Libby, P., International Atherosclerosis Society/R3i Foundation Consensus Panel, I. A. S. F. C. P., Fruchart, J., Santos, R. D., Yamashita, S., Nordestgaard, Børge, Tybjærg-Hansen, Anne, Watts, G. F., Yokote, K. & Zambon, A., 2019, In: Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 13, 4, p. 2723-2725Research output: Contribution to journal › Review › Research › peer-review
- Published
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis
Yang, Y., van der Klaauw, A. A., Zhu, L., Cacciottolo, T. M., He, Y., Stadler, L. K. J., Wang, C., Xu, P., Saito, K., Hinton, A., Yan, X., Keogh, J. M., Henning, E., Banton, M. C., Hendricks, A. E., Bochukova, E. G., Mistry, V., Lawler, K. L., Liao, L., Xu, J. & 306 others, , 2019, In: Nature Communications. 10, 14 p., 1718.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation
Fruchart, J-C., Santos, R. D., Aguilar-Salinas, C., Aikawa, M., Al Rasadi, K., Amarenco, P., Barter, P. J., Ceska, R., Corsini, A., Després, J-P., Duriez, P., Eckel, R. H., Ezhov, M. V., Farnier, M., Ginsberg, H. N., Hermans, M. P., Ishibashi, S., Karpe, F., Kodama, T., Koenig, W. & 35 others, , 2019, In: Cardiovascular Diabetology. 18, 20 p., 71.Research output: Contribution to journal › Review › Research › peer-review
- 2018
- Published
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., Guo, X., Lu, Y., Li, M., Jensen, R. A., Hu, Y., Huo, S., Lohman, K. K., Zhang, W., Cook, J. P., Prins, B. P. & 32 others, , Apr 2018, In: Nature Genetics. 50, 4, p. 559-571 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot, V., Lu, Y., Highland, H. M., Bang, L. E., Benn, M., Kamstrup, P. R., Bork-Jensen, J., Frikke-Schmidt, R., Gjesing, A. P., Grarup, N., Hansen, T., Have, C. T., Jørgensen, T., Nielsen, S. F., Linneberg, A. R., Pedersen, O., Pers, T. H., Vestergaard, H., Nordestgaard, B., Tybjærg-Hansen, A. & 15 others, , 1 Jan 2018, In: Nature Genetics. 50, p. 26-41 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Jan 2018, In: Alzheimer's & Dementia. 14, 1, p. 71-80Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ABCA7 and risk of dementia and vascular disease in the Danish population
Kjeldsen, E. W., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2018, In: Annals of Clinical and Translational Neurology. 5, 1, p. 41-51 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
APOC3 Loss-of-Function Mutations, Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Cardiovascular Risk: Mediation- and Meta-Analyses of 137 895 Individuals
Wulff, A. B., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 3, p. 660-668Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Advances in lipid-lowering therapy through gene-silencing technologies
Nordestgaard, Børge, Nicholls, S. J., Langsted, A., Ray, K. K. & Tybjærg-Hansen, Anne, 2018, In: Nature Reviews Cardiology. 15, p. 261-272Research output: Contribution to journal › Review › Research › peer-review
- Published
Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis
European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium, E. P. I. I. C. A. N. D. (. C., 2018, In: JAMA Cardiology. 3, 7, p. 619-627 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
Gusarova, V., O'Dushlaine, C., Teslovich, T. M., Benotti, P. N., Mirshahi, T., Gottesman, O., Van Hout, C. V., Murray, M. F., Mahajan, A., Nielsen, J. B., Fritsche, L., Wulff, A. B., Gudbjartsson, D. F., Sjögren, M., Emdin, C. A., Scott, R. A., Lee, W. J., Small, A., Kwee, L. C., Dwivedi, O. P. & 61 others, , 2018, In: Nature Communications. 9, 1, 2252.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease
Qayyum, F., Lauridsen, B. K., Frikke-Schmidt, Ruth, Kofoed, Klaus Fuglsang, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2018, In: European Heart Journal. 39, 22, p. 2106-2116 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: Cohort studies and meta-analyses of 362,338 individuals
Nordestgaard, L. T., Tybjærg-Hansen, Anne, Rasmussen, K. L., Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2018, In: BMC Medicine. 16, 11 p., 39.Research output: Contribution to journal › Journal article › Research › peer-review
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Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals
Lauridsen, B. K., Stender, Steen, zwp671, zwp671, Kofoed, Klaus Fuglsang, Køber, Lars Valeur, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2018, In: European Heart Journal. 39, 5, p. 385-393 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans
Oldoni, F., van Capelleveen, J. C., Dalila, N., Wolters, J. C., Heeren, J., Sinke, R. J., Hui, D. Y., Dallinga-Thie, G. M., Frikke-Schmidt, Ruth, Hovingh, K. G., van de Sluis, B., Tybjærg-Hansen, Anne & Kuivenhoven, J. A., 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 7, p. 1440-1453 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
Vallejo-Vaz, A. J., Marco, M. D., Stevens, C. A. T., Akram, A., Freiberger, T., Hovingh, G. K., Kastelein, J. J. P., Mata, P., Raal, F. J., Santos, R. D., Soran, H., Watts, G. F., Abifadel, M., Aguilar Salinas, C. A., Al-Khnifsawi, M., Alkindi, F. A., Alnouri, F., Alonso, R., Al-Rasadi, K., Al-Sarraf, A. & 248 others, , 2018, In: Atherosclerosis. 277, p. 234-255 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride
Stender, S., Smagris, E., Lauridsen, B. K., Kofoed, Klaus Fuglsang, Nordestgaard, Børge, Tybjærg-Hansen, Anne, Pennacchio, L. A., Dickel, D. E., Cohen, J. C. & Hobbs, H. H., 2018, In: Hepatology. 67, 6, p. 2182-2195 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Response to: liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease
Stender, S. & Tybjærg-Hansen, Anne, 2018, In: European Heart Journal. 39, 36, p. 3399Research output: Contribution to journal › Comment/debate › Research › peer-review
ID: 924951
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ABCA7 and risk of dementia and vascular disease in the Danish population
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254
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The UK10K project identifies rare variants in health and disease
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Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease
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