Plants are the chemists par excellence in nature. From a fixed growth place, they have to fend off animals and pests. This is partly achieved by synthesis of a multitude of bio-active natural products. In total, plants are known to produce more than 200.000 such compounds. Many of these bio-active natural products have served as lead compounds and as a source of novel structures in drug development. Knowledge of their routes of biosynthesis, regulation and transport in plants offers new tools to engineer crop and medicinal plants to contain a higher content of desired bio-active natural products and to transfer the pathways to other plants or micro organisms. The border between food and drug intake will partly vanish. Knowledge of the transport and enzymatic turn-over mechanisms of bio-active natural products may in combination with approaches from synthetic biology be used to design vesicle encapsulated nano discs harboring enzymes that inactivate harmful toxins or over-dosed drugs. A transporter in the vesicle membrane serves to concentrate the specific toxin within the vesicle lumen to facilitate turn-over. Selected examples of the approaches and results obtained will be presented.