Vascular flow reserve as a link between long-term blood pressure level and physical performance capacity in mammals
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Vascular flow reserve as a link between long-term blood pressure level and physical performance capacity in mammals. / Poulsen, Christian B; Damkjær, Mads; Hald, Bjørn O; Wang, Tobias; von Holstein-Rathlou, Niels-Henrik; Jacobsen, Jens Christian Brings.
I: Physiological Reports, Bind 4, Nr. 11, e12813, 06.2016, s. 1-21.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Vascular flow reserve as a link between long-term blood pressure level and physical performance capacity in mammals
AU - Poulsen, Christian B
AU - Damkjær, Mads
AU - Hald, Bjørn O
AU - Wang, Tobias
AU - von Holstein-Rathlou, Niels-Henrik
AU - Jacobsen, Jens Christian Brings
N1 - © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.
PY - 2016/6
Y1 - 2016/6
N2 - Mean arterial pressure (MAP) is surprisingly similar across different species of mammals, and it is, in general, not known which factors determine the arterial pressure level. Mammals often have a pronounced capacity for sustained physical performance. This capacity depends on the vasculature having a flow reserve that comes into play as tissue metabolism increases. We hypothesize that microvascular properties allowing for a large vascular flow reserve is linked to the level of the arterial pressure.To study the interaction between network properties and network inlet pressure, we developed a generic and parsimonious computational model of a bifurcating microvascular network where diameter and growth of each vessel evolves in response to changes in biomechanical stresses. During a simulation, the network develops well-defined arterial and venous vessel characteristics. A change in endothelial function producing a high precapillary resistance and thus a high vascular flow reserve is associated with an increase in network inlet pressure. Assuming that network properties are independent of body mass, and that inlet pressure of the microvascular network is a proxy for arterial pressure, the study provides a conceptual explanation of why high performing animals tend to have a high MAP.
AB - Mean arterial pressure (MAP) is surprisingly similar across different species of mammals, and it is, in general, not known which factors determine the arterial pressure level. Mammals often have a pronounced capacity for sustained physical performance. This capacity depends on the vasculature having a flow reserve that comes into play as tissue metabolism increases. We hypothesize that microvascular properties allowing for a large vascular flow reserve is linked to the level of the arterial pressure.To study the interaction between network properties and network inlet pressure, we developed a generic and parsimonious computational model of a bifurcating microvascular network where diameter and growth of each vessel evolves in response to changes in biomechanical stresses. During a simulation, the network develops well-defined arterial and venous vessel characteristics. A change in endothelial function producing a high precapillary resistance and thus a high vascular flow reserve is associated with an increase in network inlet pressure. Assuming that network properties are independent of body mass, and that inlet pressure of the microvascular network is a proxy for arterial pressure, the study provides a conceptual explanation of why high performing animals tend to have a high MAP.
KW - Animals
KW - Arterial Pressure
KW - Hemodynamics
KW - Microcirculation
KW - Microvessels
KW - Models, Cardiovascular
KW - Vascular Resistance
U2 - 10.14814/phy2.12813
DO - 10.14814/phy2.12813
M3 - Journal article
C2 - 27255360
VL - 4
SP - 1
EP - 21
JO - Physiological Reports
JF - Physiological Reports
SN - 2051-817X
IS - 11
M1 - e12813
ER -
ID: 167804195