The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling
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The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. / Benned-Jensen, Tau; Mokrosinski, Jacek; Rosenkilde, Mette M.
I: P L o S One, Bind 6, Nr. 9, 2011, s. e24644.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling
AU - Benned-Jensen, Tau
AU - Mokrosinski, Jacek
AU - Rosenkilde, Mette M
PY - 2011
Y1 - 2011
N2 - The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60 in the top of transmembrane helix II which has been identified in melanic mice and several other species. This mutation induces a pronounced increase in MC1R constitutive activity suggesting a link between constitutive activity and melanism which is corroborated by the attenuation of a-melanocyte stimulating hormone (aMSH) induced activation. However, the mechanism by which the mutation induces constitutive activity is currently not known.
AB - The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60 in the top of transmembrane helix II which has been identified in melanic mice and several other species. This mutation induces a pronounced increase in MC1R constitutive activity suggesting a link between constitutive activity and melanism which is corroborated by the attenuation of a-melanocyte stimulating hormone (aMSH) induced activation. However, the mechanism by which the mutation induces constitutive activity is currently not known.
KW - Animals
KW - Arrestin
KW - Cell Line
KW - Cyclic AMP
KW - Enzyme-Linked Immunosorbent Assay
KW - Extracellular Signal-Regulated MAP Kinases
KW - Humans
KW - Mice
KW - Microscopy, Confocal
KW - Mutagenesis, Site-Directed
KW - Mutation
KW - Phosphorylation
KW - Receptor, Melanocortin, Type 1
KW - Signal Transduction
KW - alpha-MSH
U2 - 10.1371/journal.pone.0024644
DO - 10.1371/journal.pone.0024644
M3 - Journal article
C2 - 21931793
VL - 6
SP - e24644
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
ER -
ID: 38463832