Systemically administered trefoil factors are secreted into the gastric lumen and increase the viscosity of gastric contents
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Systemically administered trefoil factors are secreted into the gastric lumen and increase the viscosity of gastric contents. / Kjellev, S.; Nexo, E.; Thim, L.; Poulsen, S.S.
I: British Journal of Pharmacology, Bind 149, Nr. 1, 2006, s. 92-99.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Systemically administered trefoil factors are secreted into the gastric lumen and increase the viscosity of gastric contents
AU - Kjellev, S.
AU - Nexo, E.
AU - Thim, L.
AU - Poulsen, S.S.
PY - 2006
Y1 - 2006
N2 - Trefoil factors (TFFs) secreted by mucus-producing cells are essential for the defence of the gastrointestinal mucosa. TFFs probably influence the viscoelastic properties of mucus, but this has not been demonstrated in vivo. We therefore studied the gastric secretion of systemically administered TFF2 and TFF3, and their influence on the viscosity of the secretions.
AB - Trefoil factors (TFFs) secreted by mucus-producing cells are essential for the defence of the gastrointestinal mucosa. TFFs probably influence the viscoelastic properties of mucus, but this has not been demonstrated in vivo. We therefore studied the gastric secretion of systemically administered TFF2 and TFF3, and their influence on the viscosity of the secretions.
KW - Animals
KW - Autoradiography
KW - Enzyme-Linked Immunosorbent Assay
KW - Female
KW - Gastrointestinal Contents
KW - Immunohistochemistry
KW - In Situ Hybridization
KW - Injections, Intravenous
KW - Mice
KW - Mice, Inbred C57BL
KW - Peptides
KW - Rats
KW - Rats, Wistar
KW - Stomach
KW - Tissue Distribution
KW - Viscosity
U2 - 10.1038/sj.bjp.0706840
DO - 10.1038/sj.bjp.0706840
M3 - Journal article
C2 - 16880764
VL - 149
SP - 92
EP - 99
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 1
ER -
ID: 1203034