Statistics and Informatics in Molecular Cancer Research
Publikation: Bog/antologi/afhandling/rapport › Bog › Forskning › fagfællebedømt
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Statistics and Informatics in Molecular Cancer Research. / Wiuf, Carsten; Andersen, Claus L.
Oxford University Press, 2009. 208 s.Publikation: Bog/antologi/afhandling/rapport › Bog › Forskning › fagfællebedømt
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TY - BOOK
T1 - Statistics and Informatics in Molecular Cancer Research
AU - Wiuf, Carsten
AU - Andersen, Claus L.
PY - 2009/9/1
Y1 - 2009/9/1
N2 - This book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters it discusses specific topics in cancer research, talks about how the topics give rise to development of new informatics and statistics tools, and explains how the tools can be applied. The focus of the book is to provide an understanding of key concepts and tools, rather than focusing on technical issues. A main theme is the extensive use of array technologies in modern cancer research - gene expression and exon arrays, SNP and copy number arrays and methylation arrays - to derive quantitative and qualitative statements about cancer, its progression and aetiology, and to understand how these technologies at one hand allow us learn about cancer tissue as a complex system and at the other hand allow us to pinpoint key genes and events as crucial for the development of the disease. Cancer is characterized by genetic and genomic alterations that influence all levels of the cell's machinery and function.
AB - This book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters it discusses specific topics in cancer research, talks about how the topics give rise to development of new informatics and statistics tools, and explains how the tools can be applied. The focus of the book is to provide an understanding of key concepts and tools, rather than focusing on technical issues. A main theme is the extensive use of array technologies in modern cancer research - gene expression and exon arrays, SNP and copy number arrays and methylation arrays - to derive quantitative and qualitative statements about cancer, its progression and aetiology, and to understand how these technologies at one hand allow us learn about cancer tissue as a complex system and at the other hand allow us to pinpoint key genes and events as crucial for the development of the disease. Cancer is characterized by genetic and genomic alterations that influence all levels of the cell's machinery and function.
KW - Array technology
KW - Cancer
KW - Copy number
KW - Gene expression
KW - Informatics
KW - Methylation
KW - Pathways
UR - http://www.scopus.com/inward/record.url?scp=84855224115&partnerID=8YFLogxK
U2 - 10.1093/acprof:oso/9780199532872.001.0001
DO - 10.1093/acprof:oso/9780199532872.001.0001
M3 - Book
AN - SCOPUS:84855224115
SN - 9780199532872
VL - 9780199532872
BT - Statistics and Informatics in Molecular Cancer Research
PB - Oxford University Press
ER -
ID: 203906121