Some notes on the combinatorial properties of haplotype tagging
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Some notes on the combinatorial properties of haplotype tagging. / Wiuf, Carsten; Laidlaw, Zoë; Stumpf, Michael P.H.
I: Mathematical Biosciences, Bind 185, Nr. 2, 01.01.2003, s. 205-216.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Some notes on the combinatorial properties of haplotype tagging
AU - Wiuf, Carsten
AU - Laidlaw, Zoë
AU - Stumpf, Michael P.H.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Tagging haplotypes with a small number of genetic markers is becoming an increasingly interesting and important problem. Surprisingly little work has been done to characterize the mathematical framework of this problem. In this paper we present a mathematical frame, based on Boolean algebras, that adequately describe the structure of a set of genetic bi-allelic markers and the corresponding set of haplotypes. We derive a number of results that relate the number of markers required to tag a set of haplotypes to the set of markers themselves.
AB - Tagging haplotypes with a small number of genetic markers is becoming an increasingly interesting and important problem. Surprisingly little work has been done to characterize the mathematical framework of this problem. In this paper we present a mathematical frame, based on Boolean algebras, that adequately describe the structure of a set of genetic bi-allelic markers and the corresponding set of haplotypes. We derive a number of results that relate the number of markers required to tag a set of haplotypes to the set of markers themselves.
KW - Block recombination
KW - Haplotype tagging
KW - SNPs
UR - http://www.scopus.com/inward/record.url?scp=0042738025&partnerID=8YFLogxK
U2 - 10.1016/S0025-5564(03)00089-0
DO - 10.1016/S0025-5564(03)00089-0
M3 - Journal article
C2 - 12941537
AN - SCOPUS:0042738025
VL - 185
SP - 205
EP - 216
JO - Mathematical Biosciences
JF - Mathematical Biosciences
SN - 0025-5564
IS - 2
ER -
ID: 203902992