Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis
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Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis. / Halling, Anne-Sofie; Rinnov, Maria Rasmussen; Ruge, Iben Frier; Gerner, Trine; Ravn, Nina Haarup; Knudgaard, Mette Hjorslev; Trautner, Simon; Loft, Nikolai; Skov, Lone; Thomsen, Simon F.; Egeberg, Alexander; Guttman-Yassky, Emma; Rosted, Aske L. L.; Petersen, Troels; Jakasa, Ivone; Kezic, Sanja; Thyssen, Jacob P.
I: Journal of Allergy and Clinical Immunology, Bind 151, Nr. 6, 2023, s. 1550-1557.e6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis
AU - Halling, Anne-Sofie
AU - Rinnov, Maria Rasmussen
AU - Ruge, Iben Frier
AU - Gerner, Trine
AU - Ravn, Nina Haarup
AU - Knudgaard, Mette Hjorslev
AU - Trautner, Simon
AU - Loft, Nikolai
AU - Skov, Lone
AU - Thomsen, Simon F.
AU - Egeberg, Alexander
AU - Guttman-Yassky, Emma
AU - Rosted, Aske L. L.
AU - Petersen, Troels
AU - Jakasa, Ivone
AU - Kezic, Sanja
AU - Thyssen, Jacob P.
N1 - Publisher Copyright: © 2022 The Authors
PY - 2023
Y1 - 2023
N2 - Background: It is unknown whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials to identify children at risk. Objectives: This study sought to examine whether skin biomarkers can predict AD during the first 2 years of life. Methods: This study enrolled 300 term and 150 preterm children at birth and followed for AD until the age of 2 years. Skin tape strips were collected at 0 to 3 days and 2 months of age and analyzed for selected immune and barrier biomarkers. Hazard ratio (HR) with 95% confidence interval (CI) using Cox regression was calculated for the risk of AD. Results: The 2-year prevalence of AD was 34.6% (99 of 286) and 21.2% (25 of 118) among term and preterm children, respectively. Skin biomarkers collected at birth did not predict AD. Elevated thymus- and activation-regulated chemokine/C-C motif chemokine ligand 17 -levels collected at 2 months of age increased the overall risk of AD (HR: 2.11; 95% CI: 1.36-3.26; P = .0008) and moderate-to-severe AD (HR: 4.97; 95% CI: 2.09-11.80; P = .0003). IL-8 and IL-18 predicted moderate-to-severe AD. Low filaggrin degradation product levels increased the risk of AD (HR: 2.04; 95% CI: 1.32-3.15; P = .001). Elevated biomarker levels at 2 months predicted AD at other skin sites and many months after collection. Conclusions: This study showed that noninvasively collected skin biomarkers of barrier and immune pathways can precede the onset of AD.
AB - Background: It is unknown whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials to identify children at risk. Objectives: This study sought to examine whether skin biomarkers can predict AD during the first 2 years of life. Methods: This study enrolled 300 term and 150 preterm children at birth and followed for AD until the age of 2 years. Skin tape strips were collected at 0 to 3 days and 2 months of age and analyzed for selected immune and barrier biomarkers. Hazard ratio (HR) with 95% confidence interval (CI) using Cox regression was calculated for the risk of AD. Results: The 2-year prevalence of AD was 34.6% (99 of 286) and 21.2% (25 of 118) among term and preterm children, respectively. Skin biomarkers collected at birth did not predict AD. Elevated thymus- and activation-regulated chemokine/C-C motif chemokine ligand 17 -levels collected at 2 months of age increased the overall risk of AD (HR: 2.11; 95% CI: 1.36-3.26; P = .0008) and moderate-to-severe AD (HR: 4.97; 95% CI: 2.09-11.80; P = .0003). IL-8 and IL-18 predicted moderate-to-severe AD. Low filaggrin degradation product levels increased the risk of AD (HR: 2.04; 95% CI: 1.32-3.15; P = .001). Elevated biomarker levels at 2 months predicted AD at other skin sites and many months after collection. Conclusions: This study showed that noninvasively collected skin biomarkers of barrier and immune pathways can precede the onset of AD.
KW - Atopic dermatitis
KW - birth cohort
KW - immune biomarkers
KW - predictive biomarkers
KW - skin barrier biomarkers
U2 - 10.1016/j.jaci.2022.11.023
DO - 10.1016/j.jaci.2022.11.023
M3 - Journal article
C2 - 36572354
AN - SCOPUS:85146905809
VL - 151
SP - 1550-1557.e6
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 6
ER -
ID: 344982243