Skin microbiome in atopic dermatitis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Skin microbiome in atopic dermatitis. / Edslev, Sofie M.; Agner, Tove; Andersen, Paal S.
I: Acta Dermato-Venereologica, Bind 100, Nr. 100-year theme Atopic dermatitis, adv00164, 2020, s. 358-366.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Skin microbiome in atopic dermatitis
AU - Edslev, Sofie M.
AU - Agner, Tove
AU - Andersen, Paal S.
PY - 2020
Y1 - 2020
N2 - Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. Filaggrin deficiency in atopic dermatitis skin might be related to the enhanced skin colonization by S. aureus. In addition, S. aureus expressing variant virulence factors have been shown to elicit atopic dermatitis-like phenotypes in mice, indicating that specific S. aureus strains can induce flare-ups. This review aims to provide an overview of the recent literature on the skin microbiome in atopic dermatitis.
AB - Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. Filaggrin deficiency in atopic dermatitis skin might be related to the enhanced skin colonization by S. aureus. In addition, S. aureus expressing variant virulence factors have been shown to elicit atopic dermatitis-like phenotypes in mice, indicating that specific S. aureus strains can induce flare-ups. This review aims to provide an overview of the recent literature on the skin microbiome in atopic dermatitis.
KW - Atopic dermatitis
KW - Filaggrin
KW - Skin microbiome
KW - Staphylococcus aureus
U2 - 10.2340/00015555-3514
DO - 10.2340/00015555-3514
M3 - Review
C2 - 32419029
AN - SCOPUS:85086346891
VL - 100
SP - 358
EP - 366
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 100-year theme Atopic dermatitis
M1 - adv00164
ER -
ID: 244917460