Serum insulin-like growth factor 1 in the aging horse
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Serum insulin-like growth factor 1 in the aging horse. / Lygren, Tone; Hansen, Sanni; Langberg, Henning; Fjeldborg, Julie; Jacobsen, Stine; Nielsen, Mette O; Schjerling, Peter; Markussen, Bo; Thomsen, Preben D; Berg, Lise C.
I: Veterinary clinical pathology / American Society for Veterinary Clinical Pathology, Bind 43, Nr. 4, 22.09.2014, s. 557-560.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Serum insulin-like growth factor 1 in the aging horse
AU - Lygren, Tone
AU - Hansen, Sanni
AU - Langberg, Henning
AU - Fjeldborg, Julie
AU - Jacobsen, Stine
AU - Nielsen, Mette O
AU - Schjerling, Peter
AU - Markussen, Bo
AU - Thomsen, Preben D
AU - Berg, Lise C
N1 - © 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology.
PY - 2014/9/22
Y1 - 2014/9/22
N2 - BACKGROUND: Insulin-like growth factor 1 (IGF-1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.OBJECTIVES: The objective of this study was to determine serum IGF-1 levels in the aging horse from early to late adulthood (age range 5-27 years).METHODS: Healthy horses (n = 72) were used in a cross-sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF-1 protein was determined using an ELISA kit validated for use in equine samples.RESULTS: No association was found between serum IGF-1 levels and age in the cross-sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF-1 levels over a 5-year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.CONCLUSIONS: In this study, there was no evidence for aging being a factor in changes of IGF-1 levels in an adult and old horse population.
AB - BACKGROUND: Insulin-like growth factor 1 (IGF-1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.OBJECTIVES: The objective of this study was to determine serum IGF-1 levels in the aging horse from early to late adulthood (age range 5-27 years).METHODS: Healthy horses (n = 72) were used in a cross-sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF-1 protein was determined using an ELISA kit validated for use in equine samples.RESULTS: No association was found between serum IGF-1 levels and age in the cross-sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF-1 levels over a 5-year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.CONCLUSIONS: In this study, there was no evidence for aging being a factor in changes of IGF-1 levels in an adult and old horse population.
U2 - 10.1111/vcp.12201
DO - 10.1111/vcp.12201
M3 - Journal article
C2 - 25250671
VL - 43
SP - 557
EP - 560
JO - Veterinary Clinical Pathology
JF - Veterinary Clinical Pathology
SN - 0275-6382
IS - 4
ER -
ID: 124549216