Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder
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Serotonin transporter genotype, salivary cortisol, neuroticism and life events : impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder. / Vinberg, Maj; Miskowiak, Kamilla; Kessing, Lars Vedel.
I: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Bind 48, 03.01.2014, s. 193-198.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Serotonin transporter genotype, salivary cortisol, neuroticism and life events
T2 - impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder
AU - Vinberg, Maj
AU - Miskowiak, Kamilla
AU - Kessing, Lars Vedel
N1 - © 2013.
PY - 2014/1/3
Y1 - 2014/1/3
N2 - OBJECTIVE: To investigate if cortisol alone or in interaction with other risk factors (familial risk, the serotonin transporter genotype, neuroticism and life events (LEs)) predicts onset of psychiatric disorder in healthy individuals at heritable risk.MATRIAL AND METHODS: In a high-risk study, 234 healthy monozygotic and dizygotic twins with or without a co-twin history of affective disorder (high and low risk twins) were baseline assessed. Participants were followed up for seven years and then reassessed with a personal interview revealing whether they had developed psychiatric illness.RESULTS: 36 participants (15.4%) developed psychiatric disorder. Using Cox proportional hazards ratio (HR) estimates neither morning nor evening salivary cortisol at baseline did predict illness onset. In multivariate Cox models, the two-way interaction between morning cortisol and LEs lifetime before baseline was significantly associated with onset. Further, the HR of onset was higher concerning individuals carrying the short allele of the 5-HTTPLR and having experienced more LEs lifetime. Familial risk for affective disorder predicted illness and the risk of onset was further increased in individuals at familial risk carrying the short allele of the 5-HTTPLR.CONCLUSIONS: Cortisol levels alone do not increase the risk of onset of psychiatric illness but the interaction of a lower cortisol level and the experience of more LEs do. The 5-HTTLPR genotype seems to interact and contribute to increased stress vulnerability in combination with other stress indicators of illness thereby adding to the risk of subsequent psychopathology.
AB - OBJECTIVE: To investigate if cortisol alone or in interaction with other risk factors (familial risk, the serotonin transporter genotype, neuroticism and life events (LEs)) predicts onset of psychiatric disorder in healthy individuals at heritable risk.MATRIAL AND METHODS: In a high-risk study, 234 healthy monozygotic and dizygotic twins with or without a co-twin history of affective disorder (high and low risk twins) were baseline assessed. Participants were followed up for seven years and then reassessed with a personal interview revealing whether they had developed psychiatric illness.RESULTS: 36 participants (15.4%) developed psychiatric disorder. Using Cox proportional hazards ratio (HR) estimates neither morning nor evening salivary cortisol at baseline did predict illness onset. In multivariate Cox models, the two-way interaction between morning cortisol and LEs lifetime before baseline was significantly associated with onset. Further, the HR of onset was higher concerning individuals carrying the short allele of the 5-HTTPLR and having experienced more LEs lifetime. Familial risk for affective disorder predicted illness and the risk of onset was further increased in individuals at familial risk carrying the short allele of the 5-HTTPLR.CONCLUSIONS: Cortisol levels alone do not increase the risk of onset of psychiatric illness but the interaction of a lower cortisol level and the experience of more LEs do. The 5-HTTLPR genotype seems to interact and contribute to increased stress vulnerability in combination with other stress indicators of illness thereby adding to the risk of subsequent psychopathology.
KW - Circadian Rhythm
KW - Cohort Studies
KW - Diseases in Twins
KW - Female
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Humans
KW - Hydrocortisone
KW - Life Change Events
KW - Male
KW - Mood Disorders
KW - Outcome Assessment (Health Care)
KW - Personality Inventory
KW - Proportional Hazards Models
KW - Psychiatric Status Rating Scales
KW - Risk Factors
KW - Saliva
KW - Serotonin Plasma Membrane Transport Proteins
U2 - 10.1016/j.pnpbp.2013.10.007
DO - 10.1016/j.pnpbp.2013.10.007
M3 - Journal article
C2 - 24140930
VL - 48
SP - 193
EP - 198
JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry
SN - 0278-5846
ER -
ID: 138726620