Recombination in human mitochondrial DNA?
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Recombination in human mitochondrial DNA? / Wiuf, Carsten.
I: Genetics, Bind 159, Nr. 2, 17.11.2001, s. 749-756.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Recombination in human mitochondrial DNA?
AU - Wiuf, Carsten
PY - 2001/11/17
Y1 - 2001/11/17
N2 - The possibility of recombination in human mitochondrial DNA (mtDNA) has been hotly debated over the last few years. In this study, a general model of recombination in circular molecules is developed and applied to a recently published African sample (n = 21) of complete mtDNA sequences. It is shown that the power of correlation measures to detect recombination in circular molecules can be vanishingly small and that the data are consistent with the given model and no recombination only if the overall heterogeneity in mutation rate is <0.09.
AB - The possibility of recombination in human mitochondrial DNA (mtDNA) has been hotly debated over the last few years. In this study, a general model of recombination in circular molecules is developed and applied to a recently published African sample (n = 21) of complete mtDNA sequences. It is shown that the power of correlation measures to detect recombination in circular molecules can be vanishingly small and that the data are consistent with the given model and no recombination only if the overall heterogeneity in mutation rate is <0.09.
UR - http://www.scopus.com/inward/record.url?scp=0034754464&partnerID=8YFLogxK
M3 - Journal article
C2 - 11606549
AN - SCOPUS:0034754464
VL - 159
SP - 749
EP - 756
JO - Genetics
JF - Genetics
SN - 1943-2631
IS - 2
ER -
ID: 203901938