Recombination as a point process along sequences
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Recombination as a point process along sequences. / Wiuf, Carsten; Hein, Jotun.
I: Theoretical Population Biology, Bind 55, Nr. 3, 01.01.1999, s. 248-259.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Recombination as a point process along sequences
AU - Wiuf, Carsten
AU - Hein, Jotun
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Histories of sequences in the coalescent model with recombination can be simulated using an algorithm that takes as input a sample of extant sequences. The algorithm traces the history of the sequences going back in time, encountering recombinations and coalescence (duplications) until the ancestral material is located on one sequence for homologous positions in the present sequences. Here an alternative algorithm is formulated not as going back in time and operating on sequences, but by moving spatially along the sequences, updating the history of the sequences as recombination points are encountered. This algorithm focuses on spatial aspects of the coalescent with recombination rather than on temporal aspects as is the case of familiar algorithms. Mathematical results related to spatial aspects of the coalescent with recombination are derived.
AB - Histories of sequences in the coalescent model with recombination can be simulated using an algorithm that takes as input a sample of extant sequences. The algorithm traces the history of the sequences going back in time, encountering recombinations and coalescence (duplications) until the ancestral material is located on one sequence for homologous positions in the present sequences. Here an alternative algorithm is formulated not as going back in time and operating on sequences, but by moving spatially along the sequences, updating the history of the sequences as recombination points are encountered. This algorithm focuses on spatial aspects of the coalescent with recombination rather than on temporal aspects as is the case of familiar algorithms. Mathematical results related to spatial aspects of the coalescent with recombination are derived.
UR - http://www.scopus.com/inward/record.url?scp=0033150745&partnerID=8YFLogxK
U2 - 10.1006/tpbi.1998.1403
DO - 10.1006/tpbi.1998.1403
M3 - Journal article
C2 - 10366550
AN - SCOPUS:0033150745
VL - 55
SP - 248
EP - 259
JO - Theoretical Population Biology
JF - Theoretical Population Biology
SN - 0040-5809
IS - 3
ER -
ID: 203901394