Methods for derivation of LOH and allelic copy numbers using SNP arrays
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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Methods for derivation of LOH and allelic copy numbers using SNP arrays. / Wiuf, Carsten; Lamy, Philippe; Andersen, Claus L.
Statistics and Informatics in Molecular Cancer Research. Bind 9780199532872 Oxford University Press, 2009.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Methods for derivation of LOH and allelic copy numbers using SNP arrays
AU - Wiuf, Carsten
AU - Lamy, Philippe
AU - Andersen, Claus L.
PY - 2009/9/1
Y1 - 2009/9/1
N2 - This chapter discusses statistical methods to derive loss-of-heterozygosity (LOH) and allele specific copy numbers in cancer cells. SNP arrays enable simultaneous information about thousands of DNA markers and their allele specific copy numbers, but to extract the information advanced statistical tools are required. The chapter shows how Hidden Markov Models (HMM) can be applied to infer LOH from genotype data and how the allele intensities are informative about allelic copy number. The methods are illustrated by examples.
AB - This chapter discusses statistical methods to derive loss-of-heterozygosity (LOH) and allele specific copy numbers in cancer cells. SNP arrays enable simultaneous information about thousands of DNA markers and their allele specific copy numbers, but to extract the information advanced statistical tools are required. The chapter shows how Hidden Markov Models (HMM) can be applied to infer LOH from genotype data and how the allele intensities are informative about allelic copy number. The methods are illustrated by examples.
KW - Allelic copy number
KW - DNA marker
KW - Genotype
KW - Hidden markov model
KW - Loss-of-heterozygosity
UR - http://www.scopus.com/inward/record.url?scp=84920121084&partnerID=8YFLogxK
U2 - 10.1093/acprof:oso/9780199532872.003.0003
DO - 10.1093/acprof:oso/9780199532872.003.0003
M3 - Book chapter
AN - SCOPUS:84920121084
SN - 9780199532872
VL - 9780199532872
BT - Statistics and Informatics in Molecular Cancer Research
PB - Oxford University Press
ER -
ID: 203899912