Maximum likelihood estimation and natural pairwise estimating equations are identical for three sequences and a symmetric 2-state substitution model
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 485 KB, PDF-dokument
Consider the problem of estimating the branch lengths in a symmetric 2-state substitution model with a known topology and a general, clock-like or star-shaped tree with three leaves. We show that the maximum likelihood estimates are analytically tractable and can be obtained from pairwise sequence comparisons. Furthermore, we demonstrate that this property does not generalize to larger state spaces, more complex models or larger trees. Our arguments are based on an enumeration of the free parameters of the model and the dimension of the minimal sufficient data vector. Our interest in this problem arose from discussions with our former colleague Freddy Bugge Christiansen.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Theoretical Population Biology |
Vol/bind | 156 |
Sider (fra-til) | 1-4 |
ISSN | 0040-5809 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
We are grateful to the editor Marcy Uyenoyama and the reviewer for comments and suggestions that substantially improved the presentation.
Publisher Copyright:
© 2024 The Authors
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 381062110