It takes two-or more-to tango: Revisiting the role of dopamine transporter oligomerization
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- It takes two—or more—to tango
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The dopamine transporter utilizes the transmembrane sodium gradient to mediate reuptake of dopamine from the extracellular space. The dopamine transporter can form dimers and possibly also higher order structures in the plasma membrane, and this oligomerization has been implicated in both trafficking and transport. However, we still do not fully understand its biological importance. A study by Sorkina et al. now describes a series of small molecules that link transporter conformation to oligomerization and endocytosis, providing an interesting step forward in an intricate dance.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 100629 |
| Tidsskrift | Journal of Biological Chemistry |
| Vol/bind | 296 |
| Antal sider | 3 |
| ISSN | 0021-9258 |
| DOI | |
| Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
Funding and additional information—The work was supported by the Lundbeck Foundation grants R266-2017-4331 (U. G.), R276-2018-792 (U. G.), Independent Research Fund Denmark—Medical Sciences (U. G. 7016-00325B), and by the Austrian Science Fund/ FWF grant W1232 (MolTag; H. H. S.), grant doc.fund DOC 33 (H. H. S.) and the WWTF (grant CS15-033) (H. H. S.).
Funding Information:
The work was supported by the Lundbeck Foundation grants R266-2017-4331 (U. G.), R276-2018-792 (U. G.), Independent Research Fund Denmark-Medical Sciences (U. G. 7016-00325B), and by the Austrian Science Fund/ FWF grant W1232 (MolTag; H. H. S.), grant doc.fund DOC 33 (H. H. S.) and the WWTF (grant CS15-033) (H. H. S.).
Publisher Copyright:
© 2021 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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