Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H
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Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H. / Larsen, Steen; Díez-Sánchez, Carmen; Rabøl, Rasmus; Ara, Ignacio; Dela, Flemming; Helge, Jørn Wulff.
I: Biochimica et Biophysica Acta - Bioenergetics, Bind 1837, Nr. 2, 02.2014, s. 226-31.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H
AU - Larsen, Steen
AU - Díez-Sánchez, Carmen
AU - Rabøl, Rasmus
AU - Ara, Ignacio
AU - Dela, Flemming
AU - Helge, Jørn Wulff
N1 - © 2013.
PY - 2014/2
Y1 - 2014/2
N2 - It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.
AB - It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.
KW - Citrate (si)-Synthase
KW - Geography
KW - Haplotypes
KW - Humans
KW - Male
KW - Middle Aged
KW - Mitochondria
KW - Muscle Fibers, Skeletal
KW - Oxidative Phosphorylation
KW - Permeability
U2 - 10.1016/j.bbabio.2013.10.009
DO - 10.1016/j.bbabio.2013.10.009
M3 - Journal article
C2 - 24184346
VL - 1837
SP - 226
EP - 231
JO - B B A - Bioenergetics
JF - B B A - Bioenergetics
SN - 0005-2728
IS - 2
ER -
ID: 106713758