Immunohistochemical localization of epidermal growth factor in the second-trimester human fetus
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Immunohistochemical localization of epidermal growth factor in the second-trimester human fetus. / Poulsen, Steen Seier; Kryger-Baggesen, N; Nexø, Ebba.
I: Histochemistry and Cell Biology, Bind 105, Nr. 2, 02.1996, s. 111-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Immunohistochemical localization of epidermal growth factor in the second-trimester human fetus
AU - Poulsen, Steen Seier
AU - Kryger-Baggesen, N
AU - Nexø, Ebba
PY - 1996/2
Y1 - 1996/2
N2 - Epidermal growth factor (EGF) is considered to be important in mammalian neonatal growth and development. In order to clarify its developmental role, we have investigated, by immunohistochemistry, the localization of EGF and the time of its first appearance in various organs from a series of 25 midtrimester human fetuses with a gestational age ranging from 13 to 22 weeks. The first detectable EGF immunoreactivity occurred in week 15-16 fetuses in the placenta, the skin, the distal tubules of the kidney, the surface epithelium of the stomach, and the tips of the small intestinal villi, as well as in a few Paneth cells. Glandular structures, such as the glands of the cardia and the pyloric part of the stomach, Brunner's glands of the duodenum, the pancreas, and the submucous glands of the trachea, showed positive EGF immunoreactivity later (week 17). Thus, apart from the kidney, staining of the surface epithelia seems to precede staining of the EGF-producing glandular structures and EGF is not present in the glands before these have already differentiated.
AB - Epidermal growth factor (EGF) is considered to be important in mammalian neonatal growth and development. In order to clarify its developmental role, we have investigated, by immunohistochemistry, the localization of EGF and the time of its first appearance in various organs from a series of 25 midtrimester human fetuses with a gestational age ranging from 13 to 22 weeks. The first detectable EGF immunoreactivity occurred in week 15-16 fetuses in the placenta, the skin, the distal tubules of the kidney, the surface epithelium of the stomach, and the tips of the small intestinal villi, as well as in a few Paneth cells. Glandular structures, such as the glands of the cardia and the pyloric part of the stomach, Brunner's glands of the duodenum, the pancreas, and the submucous glands of the trachea, showed positive EGF immunoreactivity later (week 17). Thus, apart from the kidney, staining of the surface epithelia seems to precede staining of the EGF-producing glandular structures and EGF is not present in the glands before these have already differentiated.
KW - Adult
KW - Epidermal Growth Factor
KW - Female
KW - Fetus
KW - Humans
KW - Immunohistochemistry
KW - Intestine, Small
KW - Kidney
KW - Placenta
KW - Pregnancy
KW - Pregnancy Trimester, Second
KW - Skin
KW - Time Factors
M3 - Journal article
C2 - 8852432
VL - 105
SP - 111
EP - 117
JO - Histochemistry and Cell Biology
JF - Histochemistry and Cell Biology
SN - 0948-6143
IS - 2
ER -
ID: 47486915