Immunohistochemical localization of epidermal growth factor in rat and man
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Immunohistochemical localization of epidermal growth factor in rat and man. / Poulsen, Steen Seier; Nexø, Ebba.
I: Histochemistry, Bind 85, Nr. 5, 1986, s. 389-94.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Immunohistochemical localization of epidermal growth factor in rat and man
AU - Poulsen, Steen Seier
AU - Nexø, Ebba
PY - 1986
Y1 - 1986
N2 - Epidermal growth factor (EGF) is a peptide which stimulates cell mitotic activity and differentiation, has a cytoprotective effect on the gastroduodenal mucosa, and inhibits gastric acid secretion. The immunohistochemical localization of EGF in the Brunner's glands and the submandibular glands is well documented. The localization of EGF in other tissues is still unclarified. In the present study, the immunohistochemical localization of EGF in tissues from rat, man and a 20 week human fetus were investigated. In man and rat, immunoreaction was found in the submandibular glands, the serous glands of the nasal cavity, Brunner's glands of the duodenum, the Paneth cells of the small intestine, and the tubular cells of the kidney. In the fetus EGF was found in the kidney and in the intestinal Paneth cells. Antisera raised against rat submandibular EGF did not recognize EGF in human tissues, whereas antisera against human urinary EGF worked in rat as well as man. EGF was found only in cells with an exocrine function.
AB - Epidermal growth factor (EGF) is a peptide which stimulates cell mitotic activity and differentiation, has a cytoprotective effect on the gastroduodenal mucosa, and inhibits gastric acid secretion. The immunohistochemical localization of EGF in the Brunner's glands and the submandibular glands is well documented. The localization of EGF in other tissues is still unclarified. In the present study, the immunohistochemical localization of EGF in tissues from rat, man and a 20 week human fetus were investigated. In man and rat, immunoreaction was found in the submandibular glands, the serous glands of the nasal cavity, Brunner's glands of the duodenum, the Paneth cells of the small intestine, and the tubular cells of the kidney. In the fetus EGF was found in the kidney and in the intestinal Paneth cells. Antisera raised against rat submandibular EGF did not recognize EGF in human tissues, whereas antisera against human urinary EGF worked in rat as well as man. EGF was found only in cells with an exocrine function.
KW - Animals
KW - Brunner Glands
KW - Epidermal Growth Factor
KW - Female
KW - Fetus
KW - Humans
KW - Immunoenzyme Techniques
KW - Intestine, Small
KW - Kidney
KW - Male
KW - Nasal Mucosa
KW - Rats
KW - Rats, Inbred Strains
KW - Submandibular Gland
KW - Tissue Distribution
M3 - Journal article
C2 - 3536807
VL - 85
SP - 389
EP - 394
JO - Histochemistry
JF - Histochemistry
SN - 0301-5564
IS - 5
ER -
ID: 47488977