High-intensity interval training remodels the proteome and acetylome of human skeletal muscle
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Dokumenter
- Hostrup et al_eLife_2022_Vol 11_e69802
Forlagets udgivne version, 2,56 MB, PDF-dokument
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on the proteome and acetylome of human skeletal muscle, revealing the response of 3168 proteins and 1263 lysine acetyl-sites on 464 acetylated proteins. We identified global protein adaptations to exercise training involved in metabolism, excitation-contraction coupling, and myofibrillar calcium sensitivity. Furthermore, HIIT increased the acetylation of mitochondrial proteins, particularly those of complex V. We also highlight the regulation of exercise-responsive histone acetyl-sites. These data demonstrate the plasticity of the skeletal muscle proteome and acetylome, providing insight into the regulation of contractile, metabolic and transcriptional processes within skeletal muscle. Herein, we provide a substantial hypothesis-generating resource to stimulate further mechanistic research investigating how exercise improves metabolic health.
Originalsprog | Engelsk |
---|---|
Artikelnummer | 69802 |
Tidsskrift | eLife |
Vol/bind | 11 |
Antal sider | 37 |
ISSN | 2050-084X |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
CURIS 2022 NEXS 141
© 2022, Hostrup et al.
Links
- https://www.biorxiv.org/content/10.1101/2021.02.10.430602v3.full.pdf
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