Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors
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Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors. / Spiess, Katja; Rosenkilde, Mette Marie.
G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era. red. / Craig W. Stevens. Humana Press, 2014. s. 45-64 (Methods in Pharmacology and Toxicology).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning
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TY - CHAP
T1 - Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors
AU - Spiess, Katja
AU - Rosenkilde, Mette Marie
PY - 2014
Y1 - 2014
N2 - During co-evolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7TM receptors. These include virus-encoded 7TM receptors and ligands and viral regulation of endogenous receptors. Many functional properties have been ascribed to virus-exploited 7TM receptors, and although the list of putative functions is steadily growing, the presence and/or utilization of 7TM receptors are still poorly understood for many of these. This review focuses on three well described functional properties: 1) the immune evasion strategies, exemplified by γ1-herpesvirus-encoded BILF1 receptors, the human cytomegalovirus (HCMV)-encoded US28 receptor and the Epstein-Barr virus (EBV)-regulated EBI2 (or GPR183), 2) the tissue tropism and virus-dissemination properties, exemplified by the murine CMV-encoded M33, and 3) the tumorigenic properties, exemplified by the human herpesvirus 8 (HHV8)-encoded ORF74, HCMV-US28 and EBV-BILF1. Given the general high “druggability” of 7TM receptors, and the recent progress in the understanding of in particular immune evasive functions of the virus-exploited 7TM receptors, we put a special emphasis on the progress of novel anti-viral therapeutic tools
AB - During co-evolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7TM receptors. These include virus-encoded 7TM receptors and ligands and viral regulation of endogenous receptors. Many functional properties have been ascribed to virus-exploited 7TM receptors, and although the list of putative functions is steadily growing, the presence and/or utilization of 7TM receptors are still poorly understood for many of these. This review focuses on three well described functional properties: 1) the immune evasion strategies, exemplified by γ1-herpesvirus-encoded BILF1 receptors, the human cytomegalovirus (HCMV)-encoded US28 receptor and the Epstein-Barr virus (EBV)-regulated EBI2 (or GPR183), 2) the tissue tropism and virus-dissemination properties, exemplified by the murine CMV-encoded M33, and 3) the tumorigenic properties, exemplified by the human herpesvirus 8 (HHV8)-encoded ORF74, HCMV-US28 and EBV-BILF1. Given the general high “druggability” of 7TM receptors, and the recent progress in the understanding of in particular immune evasive functions of the virus-exploited 7TM receptors, we put a special emphasis on the progress of novel anti-viral therapeutic tools
M3 - Book chapter
SN - 978-1-62703-778-5
T3 - Methods in Pharmacology and Toxicology
SP - 45
EP - 64
BT - G Protein-Coupled Receptor Genetics
A2 - Stevens, Craig W.
PB - Humana Press
ER -
ID: 138866130