Evolutionary analysis of protein interaction networks
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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Evolutionary analysis of protein interaction networks. / Wiuf, Carsten; Ratmann, Oliver.
Statistical and Evolutionary Analysis of Biological Networks. Imperial College Press, 2009. s. 17-43.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Evolutionary analysis of protein interaction networks
AU - Wiuf, Carsten
AU - Ratmann, Oliver
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Systems approaches to understanding the structure, organisation and functioning of organisms and cells are now becoming commonplace. In this chapter we focus on protein interaction networks and their potential use for inference on the evolutionary processes that have shaped the interactome, the collection of all proteins in a cell together with their physical interactions. We demonstrate that simple mathematical models may capture essential aspects of the processes and use these to develop a Bayesian likelihood-free scheme for inference on three small organisms T. pallidum, H. pylori and P. falciparum.
AB - Systems approaches to understanding the structure, organisation and functioning of organisms and cells are now becoming commonplace. In this chapter we focus on protein interaction networks and their potential use for inference on the evolutionary processes that have shaped the interactome, the collection of all proteins in a cell together with their physical interactions. We demonstrate that simple mathematical models may capture essential aspects of the processes and use these to develop a Bayesian likelihood-free scheme for inference on three small organisms T. pallidum, H. pylori and P. falciparum.
UR - http://www.scopus.com/inward/record.url?scp=78149365035&partnerID=8YFLogxK
U2 - 10.1142/9781848164345_0002
DO - 10.1142/9781848164345_0002
M3 - Book chapter
AN - SCOPUS:78149365035
SN - 9781848164338
SP - 17
EP - 43
BT - Statistical and Evolutionary Analysis of Biological Networks
PB - Imperial College Press
ER -
ID: 203906274