EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors. / Nørregaard, Kristine; Benned-Jensen, Tau; Rosenkilde, Mette Marie.
I: Current Topics in Medicinal Chemistry, Bind 11, Nr. 6, 2011, s. 618-28.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors
AU - Nørregaard, Kristine
AU - Benned-Jensen, Tau
AU - Rosenkilde, Mette Marie
PY - 2011
Y1 - 2011
N2 - 7TM receptors constitute one of the largest superfamilies of proteins in the human genome. They are involved in a large number of physiological and pathological processes in the human body and thus represent major and important drug targets for the pharmaceutical industry. Although the majority have been deorphanized, many remain orphan, and these orphan receptors constitute a large pool of potential drug targets. This review focuses on one of these orphan targets, the Epstein-Barr Virus-induced receptor 2, EBI2 (or GPR183), together with two structurally related receptors, GPR17 and GPR18. The pharmacology and "druggability" of these three receptors is reviewed through a thorough description of their structural and functional properties and in vivo biology together with a status of currently available ligands for these receptors.
AB - 7TM receptors constitute one of the largest superfamilies of proteins in the human genome. They are involved in a large number of physiological and pathological processes in the human body and thus represent major and important drug targets for the pharmaceutical industry. Although the majority have been deorphanized, many remain orphan, and these orphan receptors constitute a large pool of potential drug targets. This review focuses on one of these orphan targets, the Epstein-Barr Virus-induced receptor 2, EBI2 (or GPR183), together with two structurally related receptors, GPR17 and GPR18. The pharmacology and "druggability" of these three receptors is reviewed through a thorough description of their structural and functional properties and in vivo biology together with a status of currently available ligands for these receptors.
KW - Humans
KW - Protein Conformation
KW - Receptors, Cell Surface
KW - Receptors, G-Protein-Coupled
U2 - 10.2174/1568026611109060618
DO - 10.2174/1568026611109060618
M3 - Journal article
C2 - 21261596
VL - 11
SP - 618
EP - 628
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
SN - 1568-0266
IS - 6
ER -
ID: 48321193