Early menarche is associated with increased risk of asthma: Prospective population-based study of twins
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Early menarche is associated with increased risk of asthma : Prospective population-based study of twins. / Lieberoth, Sofie; Gade, Elisabeth; Kyvik, Kirsten Ohm; Backer, Vibeke; Thomsen, Simon Francis.
I: Respiratory Medicine, Bind 109, Nr. 5, 05.2015, s. 565-71.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Early menarche is associated with increased risk of asthma
T2 - Prospective population-based study of twins
AU - Lieberoth, Sofie
AU - Gade, Elisabeth
AU - Kyvik, Kirsten Ohm
AU - Backer, Vibeke
AU - Thomsen, Simon Francis
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015/5
Y1 - 2015/5
N2 - AIM: To examine the association between early menarche and risk of post-menarcheal asthma.METHODS: Using data from two multidisciplinary questionnaire surveys, conducted eight years apart, we prospectively studied 10,648 female twins, 12-41 years of age, from the nationwide Danish Twin Registry. Early menarche was defined as menarche before 12 years of age. We performed a cohort analysis and a co-twin control analysis including twin pairs discordant for incident asthma.RESULTS: Early menarche was observed in 9.3% of the individuals. The eight-year cumulative incidence of asthma was higher in girls with early menarche compared to girls without early menarche (7.4 vs. 4.5%), OR = 1.71 (1.31-2.22), p < 0.001; also after adjustment for BMI, current age, physical activity, education, and smoking, OR = 1.53 (1.15-2.04), p = 0.003. The unadjusted risk of asthma was increased by 8% (1-15%), p = 0.041 per year earlier menarche occurred. Among 167 twin pairs discordant for incident asthma, there was a non-significant tendency towards early menarche being more common in the asthmatic than the non-asthmatic co-twin (12.0 vs. 9.6%), OR = 1.57 (0.61-4.05), p = 0.350. The risk of asthma was not uniform in discordant monozygotic and dizygotic twins.CONCLUSION: Early menarche is associated with increased risk of asthma among Danish female twins independently of BMI, age, physical activity, educational level and smoking. Results indicate a complex relationship possibly mediated through innate and non-genetic effects.
AB - AIM: To examine the association between early menarche and risk of post-menarcheal asthma.METHODS: Using data from two multidisciplinary questionnaire surveys, conducted eight years apart, we prospectively studied 10,648 female twins, 12-41 years of age, from the nationwide Danish Twin Registry. Early menarche was defined as menarche before 12 years of age. We performed a cohort analysis and a co-twin control analysis including twin pairs discordant for incident asthma.RESULTS: Early menarche was observed in 9.3% of the individuals. The eight-year cumulative incidence of asthma was higher in girls with early menarche compared to girls without early menarche (7.4 vs. 4.5%), OR = 1.71 (1.31-2.22), p < 0.001; also after adjustment for BMI, current age, physical activity, education, and smoking, OR = 1.53 (1.15-2.04), p = 0.003. The unadjusted risk of asthma was increased by 8% (1-15%), p = 0.041 per year earlier menarche occurred. Among 167 twin pairs discordant for incident asthma, there was a non-significant tendency towards early menarche being more common in the asthmatic than the non-asthmatic co-twin (12.0 vs. 9.6%), OR = 1.57 (0.61-4.05), p = 0.350. The risk of asthma was not uniform in discordant monozygotic and dizygotic twins.CONCLUSION: Early menarche is associated with increased risk of asthma among Danish female twins independently of BMI, age, physical activity, educational level and smoking. Results indicate a complex relationship possibly mediated through innate and non-genetic effects.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Asthma
KW - Child
KW - Denmark
KW - Diseases in Twins
KW - Female
KW - Humans
KW - Logistic Models
KW - Menarche
KW - Prospective Studies
KW - Registries
KW - Risk Factors
KW - Smoking
KW - Twins
KW - Young Adult
U2 - 10.1016/j.rmed.2015.03.007
DO - 10.1016/j.rmed.2015.03.007
M3 - Journal article
C2 - 25862596
VL - 109
SP - 565
EP - 571
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 5
ER -
ID: 156346448