Early Holocene preservation differences between cortical and trabecular bone proteomes
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Skeletal sample selection for evolutionary palaeoproteomic studies is currently based on the availability of material, without taking into account the influence of bone biology on the proteome composition of living bone. A prime example concerns the cortical and trabecular bone that is present simultaneously in many skeletal elements, including those recovered from archaeological sites. These two bone components are formed and maintained in different manners and at different rates. In palaeoproteomics there is currently no empirical data demonstrating differences in composition and/or preservation of cortical and trabecular bone proteomes. Here we analyse pairs of cortical and trabecular bone from six Early Holocene ungulate rib specimens from the site of La Draga, Spain, using shotgun proteomics. We observe generally larger proteomes, a larger number of peptides, and lower rates of degradation, for the cortical bone samples compared to the trabecular bone samples. These results suggest that in degraded proteomic contexts, preference should be given to the sampling of cortical bone in order to maximise the retrieval of larger and better-preserved bone proteomes.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 104643 |
| Tidsskrift | Journal of Archaeological Science: Reports |
| Vol/bind | 57 |
| Antal sider | 10 |
| ISSN | 2352-409X |
| DOI | |
| Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
This research has been made possible through funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme, grant agreement no. 948365 (PROSPER), awarded to F.W. F.W. J.H. and M.S.S. received support from the European Union's Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie grant agreement no. 956351 (ChemArch). Z.F. received support from the European Union's Horizon Europe research and innovation programme under the Marie Sk\u0142odowska-Curie grant agreement no. 101106627 (PROMISE). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Archaeological research at La Draga is made possible through the project \u201CLandscape modelization and resource management in the transition to farming in northeaster Iberia\u201D (PID2019-109254GB-C21), funded by the Agencia Estatal de Investigaci\u00F3n (Spain), and \u201CLa Draga i la neolititzaci\u00F3 al NE de Catalunya, formaci\u00F3 i din\u00E0miques d'ocupaci\u00F3 del jaciment\u201D funded by Departament de Cultura de la Generalitat de Catalunya. We furthermore thank the Museu Arqueol\u00F2gic Comarcal de Banyoles for access to facilities and specimens. This work also contributes to EarlyFoods (SGR-Cat-2021, 00527). Work at the Novo Nordisk Foundation Center for Protein Research is funded in part by a donation from the Novo Nordisk Foundation (grant number NNF14CC0001).
Funding Information:
This research has been made possible through funding from the European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme , grant agreement no. 948365 (PROSPER), awarded to F.W. F.W., J.H. and M.S.S. received support from the European Union\u2019s Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie grant agreement no. 956351 (ChemArch). Z.F. received support from the European Union\u2019s Horizon Europe research and innovation programme under the Marie Sk\u0142odowska-Curie grant agreement no. 101106627 (PROMISE). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Archaeological research at La Draga is made possible through the project \u201CLandscape modelization and resource management in the transition to farming in northeaster Iberia\u201D ( PID2019-109254GB-C21 ), funded by the Agencia Estatal de Investigaci\u00F3n (Spain) , and \u201CLa Draga i la neolititzaci\u00F3 al NE de Catalunya, formaci\u00F3 i din\u00E0miques d'ocupaci\u00F3 del jaciment\u201D funded by Departament de Cultura de la Generalitat de Catalunya. We furthermore thank the Museu Arqueol\u00F2gic Comarcal de Banyoles for access to facilities and specimens. This work also contributes to EarlyFoods ( SGR-Cat-2021, 00527 ). Work at the Novo Nordisk Foundation Center for Protein Research is funded in part by a donation from the Novo Nordisk Foundation (grant number NNF14CC0001 ).
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© 2024 The Author(s)
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