TY - JOUR

T1 - Deficits of social cognition in bipolar disorder

T2 - Systematic review and meta-analysis

AU - Gillissie, Emily S.

AU - Lui, Leanna M. W.

AU - Ceban, Felicia

AU - Miskowiak, Kamilla

AU - Gok, Sena

AU - Cao, Bing

AU - Teopiz, Kayla M.

AU - Ho, Roger

AU - Lee, Yena

AU - Rosenblat, Joshua D.

AU - McIntyre, Roger S.

PY - 2022/3

Y1 - 2022/3

N2 - BackgroundThe association between impaired social cognition and bipolar disorder (BD) is well established. However, to our knowledge, there has not been a recent systematic review that characterizes disparate dimensions of social cognition in BD. Herein, this systematic review and meta-analysis aimed to synthesize the literature on core aspects of social cognition (i.e., Theory of Mind, emotion recognition, and social judgment) to identify potential areas of impairment.MethodsOnline databases (i.e., PubMed, Cochrane Libraries, PsycINFO) and Google Scholar were searched from inception to May 2021. Studies with populations ages ≥16 with DSM-IV or DSM-5 defined BD (I or II) either in a euthymic or symptomatic state were included. The risk of bias was measured using the ROBINS-1 tool, and the quality of the sources was evaluated using GRADE criteria. The results of the studies were quantitatively measured by synthesizing Hedge's g effect sizes through a random effects meta-analytic approach.ResultsA total of 29 studies were included in the final review (i.e., 12 studies on the Theory of Mind, 11 on emotion recognition, and 6 on social judgment). Overall, results demonstrated social cognition to be moderately impaired in individuals with BD (d = 0.59). The individual domains ranged in effect size (0.38 < d < 0.70), providing evidence for variation in impairment within social cognition.DiscussionIndividuals with BD exhibit clinically significant deficits in social cognition during euthymic and symptomatic states. Social cognition impairments in individuals with BD are an important therapeutic target for treatment discovery and development.

AB - BackgroundThe association between impaired social cognition and bipolar disorder (BD) is well established. However, to our knowledge, there has not been a recent systematic review that characterizes disparate dimensions of social cognition in BD. Herein, this systematic review and meta-analysis aimed to synthesize the literature on core aspects of social cognition (i.e., Theory of Mind, emotion recognition, and social judgment) to identify potential areas of impairment.MethodsOnline databases (i.e., PubMed, Cochrane Libraries, PsycINFO) and Google Scholar were searched from inception to May 2021. Studies with populations ages ≥16 with DSM-IV or DSM-5 defined BD (I or II) either in a euthymic or symptomatic state were included. The risk of bias was measured using the ROBINS-1 tool, and the quality of the sources was evaluated using GRADE criteria. The results of the studies were quantitatively measured by synthesizing Hedge's g effect sizes through a random effects meta-analytic approach.ResultsA total of 29 studies were included in the final review (i.e., 12 studies on the Theory of Mind, 11 on emotion recognition, and 6 on social judgment). Overall, results demonstrated social cognition to be moderately impaired in individuals with BD (d = 0.59). The individual domains ranged in effect size (0.38 < d < 0.70), providing evidence for variation in impairment within social cognition.DiscussionIndividuals with BD exhibit clinically significant deficits in social cognition during euthymic and symptomatic states. Social cognition impairments in individuals with BD are an important therapeutic target for treatment discovery and development.

KW - bipolar disorder

KW - cognitive function

KW - depression

KW - domain

KW - psychosocial function

KW - social cognition

KW - patient reported outcome (PROs)

KW - mania

KW - hypomania

KW - bipolar II disorder

KW - Theory of Mind (ToM)

U2 - 10.1111/bdi.13163

DO - 10.1111/bdi.13163

M3 - Review

C2 - 34825440

VL - 24

SP - 137

EP - 148

JO - Bipolar Disorders (English Edition, Online)

JF - Bipolar Disorders (English Edition, Online)

SN - 1399-5618

IS - 2

ER -