Calculation of Tajima's D and other neutrality test statistics from low depth next-generation sequencing data
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Calculation of Tajima's D and other neutrality test statistics from low depth next-generation sequencing data. / Korneliussen, Thorfinn Sand; Moltke, Ida; Albrechtsen, Anders; Nielsen, Rasmus.
I: B M C Bioinformatics, Bind 14, 289, 2013.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Calculation of Tajima's D and other neutrality test statistics from low depth next-generation sequencing data
AU - Korneliussen, Thorfinn Sand
AU - Moltke, Ida
AU - Albrechtsen, Anders
AU - Nielsen, Rasmus
PY - 2013
Y1 - 2013
N2 - A number of different statistics are used for detecting natural selection using DNA sequencing data, including statistics that are summaries of the frequency spectrum, such as Tajima's D. These statistics are now often being applied in the analysis of Next Generation Sequencing (NGS) data. However, estimates of frequency spectra from NGS data are strongly affected by low sequencing coverage; the inherent technology dependent variation in sequencing depth causes systematic differences in the value of the statistic among genomic regions.
AB - A number of different statistics are used for detecting natural selection using DNA sequencing data, including statistics that are summaries of the frequency spectrum, such as Tajima's D. These statistics are now often being applied in the analysis of Next Generation Sequencing (NGS) data. However, estimates of frequency spectra from NGS data are strongly affected by low sequencing coverage; the inherent technology dependent variation in sequencing depth causes systematic differences in the value of the statistic among genomic regions.
U2 - 10.1186/1471-2105-14-289
DO - 10.1186/1471-2105-14-289
M3 - Journal article
C2 - 24088262
VL - 14
JO - B M C Bioinformatics
JF - B M C Bioinformatics
SN - 1471-2105
M1 - 289
ER -
ID: 51571161