Association between serum vitamin D metabolites and metabolic function in healthy Asian adults
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Association between serum vitamin D metabolites and metabolic function in healthy Asian adults. / Ding, Cherlyn; Chan, Zhiling; Chooi, Yu Chung; Choo, John; Sadananthan, Suresh Anand; Michael, Navin; Velan, Sambasivam Sendhil; Leow, Melvin Khee-Shing; Magkos, Faidon.
I: Nutrients, Bind 12, Nr. 12, 3706, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Association between serum vitamin D metabolites and metabolic function in healthy Asian adults
AU - Ding, Cherlyn
AU - Chan, Zhiling
AU - Chooi, Yu Chung
AU - Choo, John
AU - Sadananthan, Suresh Anand
AU - Michael, Navin
AU - Velan, Sambasivam Sendhil
AU - Leow, Melvin Khee-Shing
AU - Magkos, Faidon
N1 - CURIS 2020 NEXS 363
PY - 2020
Y1 - 2020
N2 - The association between low vitamin D status and the development of type 2 diabetes mellitus is well established; however, intervention trials that increased serum vitamin D (through ultraviolet B exposure or dietary supplementation) provide mixed outcomes. Recent evidence suggests that metabolites directly related to vitamin D receptor activation-1α,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3-may be better markers of vitamin D repletion status. We tested the hypothesis that a vitamin D metabolite (VDM) index, calculated as the sum of normalized fasting serum concentrations of 1α,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3, is associated with metabolic function. We measured subcutaneous and visceral adipose tissue volume, intrahepatic triglyceride content, maximum oxygen uptake, insulin sensitivity (4 h hyperinsulinemic-euglycemic clamp), and insulin secretion (3 h meal tolerance test with mathematical modeling) and calculated the VDM index in 65 healthy Asian adults. Subjects with a low VDM index had lower peripheral insulin sensitivity and beta-cell function compared to subjects with a high VDM index (both p < 0.05), matched for age, sex, BMI, and serum 25-hydroxyvitamin D3. Serum 25-hydroxyvitamin D3 was not associated with peripheral insulin sensitivity or beta-cell function. Our results suggest that, rather than enhancing vitamin D substrate availability, upregulation of vitamin D action is more likely to lead to improvements in glucose homeostasis.
AB - The association between low vitamin D status and the development of type 2 diabetes mellitus is well established; however, intervention trials that increased serum vitamin D (through ultraviolet B exposure or dietary supplementation) provide mixed outcomes. Recent evidence suggests that metabolites directly related to vitamin D receptor activation-1α,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3-may be better markers of vitamin D repletion status. We tested the hypothesis that a vitamin D metabolite (VDM) index, calculated as the sum of normalized fasting serum concentrations of 1α,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3, is associated with metabolic function. We measured subcutaneous and visceral adipose tissue volume, intrahepatic triglyceride content, maximum oxygen uptake, insulin sensitivity (4 h hyperinsulinemic-euglycemic clamp), and insulin secretion (3 h meal tolerance test with mathematical modeling) and calculated the VDM index in 65 healthy Asian adults. Subjects with a low VDM index had lower peripheral insulin sensitivity and beta-cell function compared to subjects with a high VDM index (both p < 0.05), matched for age, sex, BMI, and serum 25-hydroxyvitamin D3. Serum 25-hydroxyvitamin D3 was not associated with peripheral insulin sensitivity or beta-cell function. Our results suggest that, rather than enhancing vitamin D substrate availability, upregulation of vitamin D action is more likely to lead to improvements in glucose homeostasis.
KW - Faculty of Science
KW - Vitamin D metabolites
KW - Metabolic dysfunction
KW - Glucose homeostasis
U2 - 10.3390/nu12123706
DO - 10.3390/nu12123706
M3 - Journal article
C2 - 33266123
VL - 12
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 12
M1 - 3706
ER -
ID: 252682344