Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor
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Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor. / Poulsen, Steen Seier; Nexø, Ebba.
I: Gut, Bind 25, Nr. 11, 11.1984, s. 1234-40.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor
AU - Poulsen, Steen Seier
AU - Nexø, Ebba
PY - 1984/11
Y1 - 1984/11
N2 - The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approximately a hundred times, while the serum concentration of EGF was unchanged. The contents of EGF in the submandibular glands decreased upon administration of the alpha-adrenergic agonist noradrenaline, and this was confirmed on immunohistochemical investigation of the glands. Beta-adrenergic agonists had no effect on secretion of EGF from the submandibular glands. Intestinal absorption of EGF could not be confirmed, as stimulation by noradrenaline with free passage of saliva to the gastrointestinal tract and intrajejunal infusion of EGF had no influence on the concentration of EGF in serum. This study shows that alpha-adrenergic agonists stimulate exocrine secretion of submandibular EGF and that EGF in physiological amounts are not absorbed in the gastrointestinal tract.
AB - The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approximately a hundred times, while the serum concentration of EGF was unchanged. The contents of EGF in the submandibular glands decreased upon administration of the alpha-adrenergic agonist noradrenaline, and this was confirmed on immunohistochemical investigation of the glands. Beta-adrenergic agonists had no effect on secretion of EGF from the submandibular glands. Intestinal absorption of EGF could not be confirmed, as stimulation by noradrenaline with free passage of saliva to the gastrointestinal tract and intrajejunal infusion of EGF had no influence on the concentration of EGF in serum. This study shows that alpha-adrenergic agonists stimulate exocrine secretion of submandibular EGF and that EGF in physiological amounts are not absorbed in the gastrointestinal tract.
KW - Adrenergic alpha-Agonists
KW - Adrenergic beta-Agonists
KW - Animals
KW - Epidermal Growth Factor
KW - Intestinal Absorption
KW - Male
KW - Rats
KW - Rats, Inbred Strains
KW - Saliva
KW - Stimulation, Chemical
KW - Submandibular Gland
M3 - Journal article
C2 - 6149980
VL - 25
SP - 1234
EP - 1240
JO - Gut
JF - Gut
SN - 0017-5749
IS - 11
ER -
ID: 47489219